2. TGF-beta/Smad Metabolic Enzyme/Protease Membrane Transporter/Ion Channel
  3. TGF-β Receptor Hepcidin Ferroportin
  4. KY1070

KY1070 is a fully human anti-BMP6 antibody with a Kd of 0.00014 μM against the human BMP6. It exhibits high specificity for BMP6, showing no cross-reactivity with other members of the BMP family, and effectively inhibits BMP6-induced BMP receptor heterodimerization and hepcidin expression. KY1070 modulates Ferroportin expression on erythroid progenitor cells and accelerates erythropoiesis. In rodent anemia models, KY1070 reduces the required dose of erythropoietin (EPO) when used in combination with EPO and enhances the responsiveness of mice with chronic kidney disease (CKD)-associated anemia to EPO treatment. KY1070 is applicable for research on anemia of chronic disease [1] [2].

For research use only. We do not sell to patients.

KY1070

KY1070 Chemical Structure

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KY1070 Related Antibodies

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Description

KY1070 is a fully human anti-BMP6 antibody with a Kd of 0.00014 μM against the human BMP6. It exhibits high specificity for BMP6, showing no cross-reactivity with other members of the BMP family, and effectively inhibits BMP6-induced BMP receptor heterodimerization and hepcidin expression. KY1070 modulates Ferroportin expression on erythroid progenitor cells and accelerates erythropoiesis. In rodent anemia models, KY1070 reduces the required dose of erythropoietin (EPO) when used in combination with EPO and enhances the responsiveness of mice with chronic kidney disease (CKD)-associated anemia to EPO treatment. KY1070 is applicable for research on anemia of chronic disease [1] [2].

Species Reactivity

Human
IC50 & Target

hBMP6

0.00014 μM (Kd)

In Vitro

KY1070 (starting at a final concentration of 600 nM) binds recombinant human BMP6, neutralizes BMP6 from multiple species, lacks cross-reactivity to other BMPs, and inhibits BMPR heterodimerization (Kd = 140 pM)[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

KY1070 Related Antibodies
In Vivo

KY1070 (3 mg/kg; single injection) modulates iron homeostasis in Bmp6 wild-type mice[1].
KY1070 (0.1-3 mg/kg) increases EPO sensitivity in male C57BL/6N mice with CKD[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Bmp6 wild-type mice; Bmp6-deficient mice[1]
Dosage: 3 mg/kg
Administration: single injection
Result: Significantly decreased hepatic Hamp mRNA and increased plasma iron levels in Bmp6-wt mice; showed no effect on hepatic Hamp mRNA or plasma iron levels in Bmp6^-/- mice
Gene ID

654  [NCBI]

Accession

P22004
Application

ELISA, FACS, Functional assay
Conjugated

Unconjugated
Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.
Formulation

Please refer to the lot-specific COA for specific buffer information.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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KY1070 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

KY1070KY 1070KY-1070TGF-β ReceptorHepcidinFerroportinTransforming growth factor beta receptorsIron-regulated Transporter 1anemia of chronic diseaseBone Morphogenetic Protein 6C57BL/6N miceferroportinACDBmp6 wild-type miceLewis ratshepcidinEPOCKDerythroid precursor cellsBMP6Bmp6 deficient micerodent anemia modelsHamp promoterInhibitorinhibitorinhibit

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