Transferrins 

Transferrin, a blood-plasma glycoprotein, is a target ligand for transferrin receptor. Transferrins can bind to and mediate the transport of iron^[1][2][3].

Transferrin receptor^[1]

Transferrins (0.2, 1 and 5 μM, 30 min) enhances the enzymatic activity of thrombin^[2].
Transferrins (0.2, 1 and 5 μM, 30 min) enhances the ability of thrombin and FXIIa to hydrolyze their natural substrates (fibrinogen)^[2].
Transferrins can conjugate with cytochrome c, the conjugates can be uptaken by transferrin receptor overexpressing A549 cells, thereby inducing cell death^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

11096-37-0

Solid

Brown to reddish brown

[Transferrins]

Room temperature in continental US; may vary elsewhere.

Sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

• [1]. Li H, et al. Transferrin/transferrin receptor-mediated drug delivery. Med Res Rev. 2002 May;22(3):225-50.  [Content Brief]

  [2]. Tang X, et al. Transferrin plays a central role in coagulation balance by interacting with clotting factors. Cell Res. 2020 Feb;30(2):119-132.  [Content Brief]

  [3]. Saxena M, et al. Inducing cell death in vitro in cancer cells by targeted delivery of cytochrome c via a transferrin conjugate. PLoS One. 2018 Apr 12;13(4):e0195542.  [Content Brief]