Ferroportin Inhibitor

DMT1 blocker 2 is a direct inhibitor of divalent metal transporter 1 (DMT1), with an IC₅₀ of 0.83 μM. DMT1 blocker 2 can block iron uptake by enterocytes in vivo.

DMT1 blocker 1 is an orally active blocker of divalent metal transporter 1 (DMT1) with an IC₅₀ of 0.64 μM. DMT1 blocker 1 inhibits intestinal cell absorption of non-heme iron, thereby alleviating iron overload by blocking the DMT1 transporter. DMT1 blocker 1 demonstrates significant efficacy in rodent models of acute iron hyperabsorption. DMT1 blocker 1 is useful for studying iron overload disorders such as hereditary hemochromatosis and thalassemia.

Ferroptosis inducer-16 (anti-NSCLC agent-2) is a nitric oxide (NO) donor and a ferroptosis inducer. Ferroptosis inducer-16 inhibits DNA synthesis and colony formation. Ferroptosis inducer-16 disrupts lysosomal integrity by releasing NO, triggers iron overload and oxidative stress, downregulates the SLC7A11-GPX4 axis, depletes GSH, and accumulates lipid peroxides. Ferroptosis inducer-16 inhibits tumor growth in an OVCAR8/ADR xenograft mouse model without obvious toxicity, and can be used in the study of non-small cell lung cancer and drug-resistant ovarian cancer.

Fursultiamine is a vitamin B₁ derivative, has anti-nociceptive and antineoplastic activity. Fursultiamine can be used for vitamin B₁?deficiency, osteoarthritis (OA) and cancer research.

DS28120313 (compound 32) is an orally hepcidin production inhibitor with an IC₅₀ of 0.093 μM.

LY2928057 is a CHO-expressed human antibody that targets SLC40A1/Ferroportin. The predicted molecular weight (MW) of LY2928057 is 150 kDa. The isotype control for LY2928057 can be referenced as Human IgG4 kappa, Isotype Control (HY-P99003).

Fursultiamine (Standard) is the analytical standard of Fursultiamine. This product is intended for research and analytical applications. Fursultiamine is a vitamin B₁ derivative, has anti-nociceptive and antineoplastic activity. Fursultiamine can be used for vitamin B₁ deficiency, osteoarthritis (OA) and cancer research.

Pyrimidinone 8 is a reversible linear non-competitive inhibitor of divalent metal transporter 1 (DMT1), with a K_i of 20 μM (hDMT1). Pyrimidinone 8 does not affect hDMT1 cell surface expression and shows no dependence with the extracellular pH. Pyrimidinone 8 can inhibit hDMT1-mediated iron uptake, with an IC₅₀ of 13.8 μM.

DS42450411 is an orally active hepcidin production inhibitor with an IC₅₀ of 32 nM. DS42450411 in an acute inflammatory mouse model induced by IL-6, DS42450411 significantly reduces serum hepcidin levels. DS42450411 can be used for studying iron homeostasis.

DS28120313 (Standard) is the analytical standard of DS28120313 (HY-107980). This product is intended for research and analytical applications. DS28120313 (compound 32) is an orally hepcidin production inhibitor with an IC₅₀ of 0.093 μM.