2. Signaling Pathways
  3. Membrane Transporter/Ion Channel
  4. Ferroportin
  5. Ferroportin Inhibitor

Ferroportin Inhibitor

Ferroportin Inhibitors (9):

Cat. No. Product Name Effect Purity
  • HY-126302
    DMT1 blocker 2
    		Inhibitor 99.93%
    DMT1 blocker 2 is a direct inhibitor of divalent metal transporter 1 (DMT1), with an IC50 of 0.83 μM. DMT1 blocker 2 can block iron uptake by enterocytes in vivo.
  • HY-126301
    DMT1 blocker 1
    		Inhibitor 99.71%
    DMT1 blocker 1 is an orally active blocker of divalent metal transporter 1 (DMT1) with an IC50 of 0.64 μM. DMT1 blocker 1 inhibits intestinal cell absorption of non-heme iron, thereby alleviating iron overload by blocking the DMT1 transporter. DMT1 blocker 1 demonstrates significant efficacy in rodent models of acute iron hyperabsorption. DMT1 blocker 1 is useful for studying iron overload disorders such as hereditary hemochromatosis and thalassemia.
  • HY-B2082
    Fursultiamine
    		Inhibitor 99.71%
    Fursultiamine is a vitamin B1 derivative, has anti-nociceptive and antineoplastic activity. Fursultiamine can be used for vitamin B1?deficiency, osteoarthritis (OA) and cancer research.
  • HY-107980
    DS28120313
    		Inhibitor 98.00%
    DS28120313 (compound 32) is an orally hepcidin production inhibitor with an IC50 of 0.093 μM.
  • HY-P990618
    LY2928057
    		Inhibitor 99.9%
    LY2928057 is a CHO-expressed human antibody that targets SLC40A1/Ferroportin. The predicted molecular weight (MW) of LY2928057 is 150 kDa. The isotype control for LY2928057 can be referenced as Human IgG4 kappa, Isotype Control (HY-P99003).
  • HY-B2082R
    Fursultiamine (Standard)
    		Inhibitor
    Fursultiamine (Standard) is the analytical standard of Fursultiamine. This product is intended for research and analytical applications. Fursultiamine is a vitamin B1 derivative, has anti-nociceptive and antineoplastic activity. Fursultiamine can be used for vitamin B1 deficiency, osteoarthritis (OA) and cancer research.
  • HY-124703
    Pyrimidinone 8
    		Inhibitor
    Pyrimidinone 8 is a reversible linear non-competitive inhibitor of divalent metal transporter 1 (DMT1), with a Ki of 20 μM (hDMT1). Pyrimidinone 8 does not affect hDMT1 cell surface expression and shows no dependence with the extracellular pH. Pyrimidinone 8 can inhibit hDMT1-mediated iron uptake, with an IC50 of 13.8 μM.
  • HY-125288
    DS42450411
    		Inhibitor
    DS42450411 is an orally active hepcidin production inhibitor with an IC50 of 32 nM. DS42450411 in an acute inflammatory mouse model induced by IL-6, DS42450411 significantly reduces serum hepcidin levels. DS42450411 can be used for studying iron homeostasis.
  • HY-107980R
    DS28120313 (Standard)
    		Inhibitor
    DS28120313 (Standard) is the analytical standard of DS28120313 (HY-107980). This product is intended for research and analytical applications. DS28120313 (compound 32) is an orally hepcidin production inhibitor with an IC50 of 0.093 μM.