1. GPCR/G Protein
  2. Somatostatin Receptor

Octreotide acetate (Synonyms: SMS 201-995 (acetate))

Cat. No.: HY-17365 Purity: 99.78%
Handling Instructions

Octreotide acetate, a long-acting synthetic analog of native somatostatin, inhibits growth hormone, glucagon, and insulin more potently.

For research use only. We do not sell to patients.

Octreotide acetate Chemical Structure

Octreotide acetate Chemical Structure

CAS No. : 79517-01-4

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 71 In-stock
Estimated Time of Arrival: December 31
10 mg USD 60 In-stock
Estimated Time of Arrival: December 31
50 mg USD 115 In-stock
Estimated Time of Arrival: December 31
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200 mg   Get quote  

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Other Forms of Octreotide acetate:

  • Biological Activity

  • Protocol

  • Technical Information

  • Purity & Documentation

  • References

Description

Octreotide acetate, a long-acting synthetic analog of native somatostatin, inhibits growth hormone, glucagon, and insulin more potently.

In Vivo

Octreotide-treated groups show a significant reduction in the tumor volume when compared with saline group. Octreotide-PPSG (1.4 mg/kg, i.p.) shows greater antitumor effect than Octreotide-soln (100 μg/kg, i.p.). Octreotide-treatments results in significant inhibitory effect on the expression levels of SSTR2 and SSTR5 in primary HCC-bearing rats compared with the saline group. Octreotide-PPSG appears to inhibit the expression of SSTR2 and SSTR5 to a greater extent than that of Octreotide-soln treated group[1]. A test dose of octreotide acetate significantly decreases the serum gastrin level to approximately one third of the baseline in 2 hr and the effect lasted approximately for 6 hr. On day 21, treatment with sustained-release formulation of octreotide acetatea (5 mg intramuscular, q 4 wk) is initiated[2].

Solvent & Solubility
In Vitro: 

DMSO : ≥ 29 mg/mL (26.87 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.9265 mL 4.6327 mL 9.2654 mL
5 mM 0.1853 mL 0.9265 mL 1.8531 mL
10 mM 0.0927 mL 0.4633 mL 0.9265 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Animal Administration
[1]

Mice[1]
Thirty mice with HCC xenografts are randomLy divided into three groups: (A) Octreotide-soln group, (B) Octreotide-PPSG group, and (C) control group. Octreotide-soln group receives i.p. injection of 100 μg/kg octreotide-soln once a day and totally for consecutive 14 days. Octreotide-PPSG group receives a single subcutaneous injection of 1.4 mg/kg Octreotide-PPSG, and the injection volume is about 0.2 mL. Control group receives i.p. injection of saline once a day for consecutive 14 days. Treatment starts on the next day after injection of H22 hepatoma cell suspension and maintains for 14 days. Tumor growth is monitored by periodic caliper measurements on day 7 and day 14 post seeding. Tumor volumes (V) are calculated based on the length and width of tumor by Eq.
Rats[1]
Twelve male SD rats are divided into two groups, and housed in standard cages at 25°C, with free access to food and water for a week prior to the experiment. Rats are subcutaneously injected with Octreotidereotide solution (Octreotide-soln) or Octreotide-PPSG at an equivalent single dose of 20 mg/kg. The dose is determined based on the clinical dose of Octreotide-soln in human. Rats are fasted for 12 h before dosing and food is returned approximately 2 h post dosing. Blood samples are collected at predetermined time points using heparinized Eppendorf tubes. Immediately after collection, the blood samples are placed on ice until centrifuged at 3000 g for 10 min within 1 h. The plasma is collected and stored at −20°C until analysis.

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References
Molecular Weight

1079.29

Formula

C₅₁H₇₀N₁₀O₁₂S₂

CAS No.

79517-01-4

SMILES

CC(O)=O.NC(C(NC(C(NC(C(NC(CC1=CNC2=C1C=CC=C2)C3=O)=O)CC4=CC=CC=C4)=O)CSSCC(C(NC(CO)C(O)C)=O)NC(C(NC(C(CCCCN)N3)=O)C(O)C)=O)=O)CC5=CC=CC=C5

Storage

4°C, protect from light

Shipping

Room temperature in continental US; may vary elsewhere

Purity: 99.78%

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Product Name:
Octreotide acetate
Cat. No.:
HY-17365
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Octreotide acetate

Cat. No.: HY-17365