Dapiglutide
Based on 1 publication(s) in Google Scholar
Dapiglutide (ZP7570) is a long-acting glucagon-like peptide-1 receptor 1R (GLP-1R)/Glucagon-like peptide-2 receptor (GLP-2R) dual agonist. Dapiglutide alleviates intestinal dysfunction in a mouse short bowel model and has anti-obesity effects.
For research use only. We do not sell to patients.
- Purity: 98.52%
- CAS No.: 2296814-85-0
- Formula: C192H302N46O57
- Molecular Weight:4166.79
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Storage:
Sealed storage, away from moisture and light, under nitrogen.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen)
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Biological Activity
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Chemical Information
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Solvent & Solubility
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Publications Citing Use of MedChemExpress (MCE) Dapiglutide
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Biological Activity
Dapiglutide has an EC50 of 190 pM for GLP-1R and an EC50 of 210 pM for GLP-2R in HEK293 cells[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Dapiglutide (100 nmol/kg, once daily for four weeks) can reduce body weight in obese mice[3].
Pharmacokinetic Analysis in MC38 Syngeneic Model[2]
| Route | Dose (nmol/kg) | Animal | T1/2 (h) | Tmax (h) | F (%) |
| s.c. | 10 | Mice | 3.6 | 4.5 | 71 |
| s.c. | 10 | Rats | 7.7 | 9.0 | 58 |