Cat. No.: HY-112942A

CMP-Sialic acid sodium salt

(Synonyms: CMP-Neu5Ac sodium salt)

3 Cited Publications

Customer Review

Based on 3 publication(s) in Google Scholar

CMP-Sialic acid (CMP-Neu5Ac) sodium salt is an allosteric inhibitor of UDP-GlcNAc 2-epimerase. CMP-Sialic acid sodium salt provides a substrate for Golgi sialyltransferases. CMP-Sialic acid sodium salt is an important sugar nucleotide for biosynthesis of sialic acid and its conjugates.

For research use only. We do not sell to patients.

Purity: 90.83%
CAS No.: 1007117-62-5
Formula: C₂₀H₃₀N₄NaO₁₆P
Molecular Weight:636.43

Storage:

Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month

CMP-Sialic acid sodium salt Chemical Structure

CAS No.: 1007117-62-5

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Publications (3)
Solvent & Solubility
- In Vitro
Purity & Documentation
References
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target

Human Endogenous Metabolite

All Endogenous Metabolite Isoforms :

In Vitro

CMP-Sialic acid sodium salt (22.5 μM, 45 min) can be used as a CMAH substrate to detect the formation of Neu5Gc in platelet lysates^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 1007117-62-5
Appearance Solid
Molecular Weight 636.43
Formula C₂₀H₃₀N₄NaO₁₆P
Color White to off-white
SMILES

O[C@@H]1[C@H](O[C@@H](N2C(N=C(N)C=C2)=O)[C@@H]1O)COP(O[C@@]3(O[C@@]([C@H](NC(C)=O)[C@@H](O)C3)([H])[C@H](O)[C@H](O)CO)C(O)=O)(O[Na])=O
Synonyms

CMP-Neu5Ac sodium salt
Structure Classification
- Others
Initial Source
- Endogenous metabolite
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Publications (3)

All In Vivo Efficacy StudyELISA

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Journal Impact Factor

Nature

Lithocholic acid phenocopies anti-ageing effects of calorie restriction. [Abstract]

2025 Jul;643(8070):192-200. PMID: 39695227
Adv Mater

Shutting Down the 'Language Encoder': A Pathogen-Derived Nano-Interferer Disrupt Sialylation Metabolism and Reprogram Intercellular Communication in Glioblastoma. [Abstract]

2025 Nov 29:e16608. PMID: 41316829
Cell Host Microbe

Interferon-epsilon, an estrogen-induced type I interferon, is uniquely exploited by Neisseria gonorrhoeae via effects on sialic acid metabolism. [Abstract]

2025 Jul 9;33(7):1133-1145.e4. PMID: 40494348

CMP-Sialic acid sodium salt purchased from MedChemExpress. Usage Cited in: Cell Host Microbe. 2025 Jul 9;33(7):1133-1145.e4. [Abstract]

CMP-Neu5Ac (CMP-Sialic acid sodium salt; 25 μg; i.vag.; once daily for 8 d), the product of CMAS, enhanced gonococcal burden in C57BL/6 J WT and Ifnε^−/− mice when administered intravaginally.

CMP-Sialic acid sodium salt purchased from MedChemExpress. Usage Cited in: Cell Host Microbe. 2025 Jul 9;33(7):1133-1145.e4. [Abstract]

Intravaginal CMP-Neu5Ac (CMP-Sialic acid sodium salt; 25 μg; i.vag.; once daily for 8 days) instillation restored LOS sialylation in Ifnε^−/− and anti-IFNAR-treated mice.

Solvent & Solubility

In Vitro:

H₂O : 100 mg/mL (157.13 mM; Need ultrasonic)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

1.5713 mL

7.8563 mL

15.7126 mL

5 mM

0.3143 mL

1.5713 mL

3.1425 mL

10 mM

0.1571 mL

0.7856 mL

1.5713 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (276 KB)
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Münster AK, et al. Mammalian cytidine 5'-monophosphate N-acetylneuraminic acid synthetase: a nuclear protein with evolutionarily conserved structural motifs. Proc Natl Acad Sci U S A. 1998 Aug 4;95(16):9140-5. [Content Brief]

[2]. Jing Song, et al. Reassembled Biosynthetic Pathway for a Large-scale Synthesis of CMP-Neu5Ac. Mar Drugs. 2003 Dec; 1(4): 34-45.

[3]. Mercado CP, et al. A serotonin-induced N-glycan switch regulates platelet aggregation. Sci Rep. 2013 Sep 30;3:2795. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
H₂O	1 mM	1.5713 mL	7.8563 mL	15.7126 mL	39.2816 mL
	5 mM	0.3143 mL	1.5713 mL	3.1425 mL	7.8563 mL
	10 mM	0.1571 mL	0.7856 mL	1.5713 mL	3.9282 mL
	15 mM	0.1048 mL	0.5238 mL	1.0475 mL	2.6188 mL
	20 mM	0.0786 mL	0.3928 mL	0.7856 mL	1.9641 mL
	25 mM	0.0629 mL	0.3143 mL	0.6285 mL	1.5713 mL
	30 mM	0.0524 mL	0.2619 mL	0.5238 mL	1.3094 mL
	40 mM	0.0393 mL	0.1964 mL	0.3928 mL	0.9820 mL
	50 mM	0.0314 mL	0.1571 mL	0.3143 mL	0.7856 mL
	60 mM	0.0262 mL	0.1309 mL	0.2619 mL	0.6547 mL
	80 mM	0.0196 mL	0.0982 mL	0.1964 mL	0.4910 mL
	100 mM	0.0157 mL	0.0786 mL	0.1571 mL	0.3928 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Keywords

CMP-Sialic acid sodium salt

3 Cited Publications

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CMP-Sialic acid sodium salt

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Human Endogenous Metabolite Compound Library

Publications Citing Use of MedChemExpress (MCE) CMP-Sialic acid sodium salt

All Endogenous Metabolite Isoforms

Biological Activity

Chemical Information

Publications (3)

Solvent & Solubility

Purity & Documentation

References

Help & FAQs

Complete Stock Solution Preparation Table

CMP-Sialic acid sodium salt

Covalent Screening Library

Glucose Metabolism Compound Library

Human Metabolite Library

Heterocyclic Compound Library

Animal-Sourced Natural Product Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Covalent Screening Library Plus

Natural Product Library Plus

Bioactive Compound Library

High-Throughput Bioactive Compound Library

High-Throughput Natural Product Library

Mass Spectrometry Human Endogenous Metabolite Library

Mass Spectrometry Human Metabolite Library

Natural Product Diversity Scaffold Library

Mass Spectrometry Natural Product Library

Natural Product and Natural Product-Like Compound Library

Metabolism/Protease Compound Library

Natural Product Library

Human Endogenous Metabolite Compound Library

Publications Citing Use of MedChemExpress (MCE) CMP-Sialic acid sodium salt

All Endogenous Metabolite Isoforms

Biological Activity

Chemical Information

Publications (3)

Solvent & Solubility

Purity & Documentation

References

Help & FAQs

Complete Stock Solution Preparation Table

CMP-Sialic acid sodium salt Related Classifications

HY-112942A Related Classifications