1. Apoptosis
  2. Apoptosis
    Caspase
  3. Taurodeoxychloic Acid sodium hydrate

Taurodeoxychloic Acid sodium hydrate (Synonyms: Sodium taurodeoxycholate monohydrate)

Cat. No.: HY-B1899A Purity: >98.0%
Handling Instructions

Taurodeoxychloic Acid (sodium hydrate) prevents apoptosis by blocking a calcium-mediated apoptotic pathway as well as caspase-12 activation. Taurodeoxychloic Acid (sodium hydrate) is investigated for use in several conditions such as Primary Biliary Cirrhosis (PBC), insulin resistance, amyloidosis, Cystic Fibrosis, Cholestasis, and Amyotrophic Lateral Sclerosis.

For research use only. We do not sell to patients.

Taurodeoxychloic Acid sodium hydrate Chemical Structure

Taurodeoxychloic Acid sodium hydrate Chemical Structure

CAS No. : 110026-03-4

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 55 In-stock
Estimated Time of Arrival: December 31
10 mg USD 50 In-stock
Estimated Time of Arrival: December 31
50 mg USD 140 In-stock
Estimated Time of Arrival: December 31
100 mg   Get quote  
200 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

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  • Biological Activity

  • Technical Information

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Description

Taurodeoxychloic Acid (sodium hydrate) prevents apoptosis by blocking a calcium-mediated apoptotic pathway as well as caspase-12 activation. Taurodeoxychloic Acid (sodium hydrate) is investigated for use in several conditions such as Primary Biliary Cirrhosis (PBC), insulin resistance, amyloidosis, Cystic Fibrosis, Cholestasis, and Amyotrophic Lateral Sclerosis[1].

IC50 & Target

Caspase-12

 

In Vivo

Taurodeoxychloic Acid (TUDCA) is neuroprotective in a transgenic animal model of Huntington’s disease[2].

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (231.18 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.8494 mL 9.2471 mL 18.4942 mL
5 mM 0.3699 mL 1.8494 mL 3.6988 mL
10 mM 0.1849 mL 0.9247 mL 1.8494 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (3.85 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (3.85 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (3.85 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
Molecular Weight

540.71

Formula

C₂₆H₄₇NNaO₇S+

CAS No.

110026-03-4

SMILES
Shipping

Room temperature in continental US; may vary elsewhere

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

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Product Name:
Taurodeoxychloic Acid sodium hydrate
Cat. No.:
HY-B1899A
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Taurodeoxychloic Acid sodium hydrate

Cat. No.: HY-B1899A