Glycolithocholic acid 3-sulfate
Based on 1 Customer Validation
Glycolithocholic acid 3-sulfate (SLCG) is a cholic acid derivative and a metabolite of glycolithocholic acid. Glycolithocholic acid 3-sulfate inhibits replication of HIV-1 in vitro. Glycolithocholic acid 3-sulfate can be used for the research of HIV infection and gallbladder disease.
For research use only. We do not sell to patients.
- Purity: 99.21%
- CAS No.: 15324-64-8
- Formula: C26H43NO7S
- Molecular Weight:513.69
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Storage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
All Endogenous Metabolite Isoforms
More
Biological Activity
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Microbial Metabolite |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HEK293 | IC50 |
10 μM
Compound: Glycolithocholate-3-sulfate
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TP_TRANSPORTER: inhibition of E217betaG uptake in membrane vesicles from MRP4-expressing HEK-293 cells
TP_TRANSPORTER: inhibition of E217betaG uptake in membrane vesicles from MRP4-expressing HEK-293 cells
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[PMID: 12523936] |
Glycolithocholic acid 3-sulfate (100 μg/mL) protects MT-4 cells against HIV-1-induced cytopathogenicity[1]. Glycolithocholic acid 3-sulfate (200 μg/mL) shows no toxicity for host cells[1]. Glycolithocholic acid 3-sulfate inhibits HIV-1 antigen expression in HIV-1-infected CEM cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Male Wistar rats with bile fistula[2]
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Dosage:24 μmoL/100 g
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Administration:Intravenous injection; 24 μmoL/100 g
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Result:Induced intrahepatic cholestasis and increased biliary cholesterol secretion.
Chemical Information
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CAS No. 15324-64-8
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Appearance Solid
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Molecular Weight 513.69
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Formula C26H43NO7S
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Color White to off-white
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SMILES
C[C@@]12[C@@]([H])(CC[C@@]2([C@@H](CCC(NCC(O)=O)=O)C)[H])[C@]3([C@]([H])(CC1)[C@@]4([C@]([H])(CC3)C[C@@H](CC4)OS(=O)(O)=O)C)[H]
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Synonyms
Glycolithocholate sulfate; Sulfolithocholylglycine; SLCG
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 5 mg/mL (9.73 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (272 KB)
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SDS (254 KB)
- English - EN (254 KB)
- Français - FR (254 KB)
- Deutsch - DE (254 KB)
- Norwegian - NO (254 KB)
- Español - ES (254 KB)
- Swedish - SV (254 KB)
- Italian - IT (254 KB)
- Korean - KR (254 KB)
- Portuguese - PT (254 KB)
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Handling Instructions (2659 KB)
References
[1]. Baba M, et al. Selective activity of several cholic acid derivatives against human immunodeficiency virus replication in vitro. J Acquir Immune Defic Syndr (1988). 1989;2(3):264-71. [Content Brief]
[2]. Yousef IM,et al. Lithocholate cholestasis--sulfated glycolithocholate-induced intrahepatic cholestasis in rats. Gastroenterology. 1981 Feb;80(2):233-41. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.9467 mL | 9.7335 mL | 19.4670 mL | 48.6675 mL |
| 5 mM | 0.3893 mL | 1.9467 mL | 3.8934 mL | 9.7335 mL |
Glycolithocholic acid 3-sulfate Related Classifications
HY-113074 Related Classifications
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