Glycolithocholic acid 3-sulfate  (Synonyms: Glycolithocholate sulfate; Sulfolithocholylglycine; SLCG)

Glycolithocholic acid 3-sulfate (SLCG) is a cholic acid derivative and a metabolite of glycolithocholic acid. Glycolithocholic acid 3-sulfate inhibits replication of HIV-1 in vitro. Glycolithocholic acid 3-sulfate can be used for the research of HIV infection and gallbladder disease^[1][2].

Glycolithocholic acid 3-sulfate (100 μg/mL) protects MT-4 cells against HIV-1-induced cytopathogenicity^[1].
Glycolithocholic acid 3-sulfate (200 μg/mL) shows no toxicity for host cells^[1].
Glycolithocholic acid 3-sulfate inhibits HIV-1 antigen expression in HIV-1-infected CEM cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Glycolithocholic acid 3-sulfate (24 μmoL /100 g; i.v., once) induces intrahepatic cholestasis and increases biliary cholesterol secretion in male Wistar rats with bile fistula^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

513.69

C₂₆H₄₃NO₇S

15324-64-8

Solid

White to off-white

C[C@@]12[C@@]([H])(CC[C@@]2([C@@H](CCC(NCC(O)=O)=O)C)[H])[C@]3([C@]([H])(CC1)[C@@]4([C@]([H])(CC3)C[C@@H](CC4)OS(=O)(O)=O)C)[H]

Room temperature in continental US; may vary elsewhere.

• [1]. Baba M, et al. Selective activity of several cholic acid derivatives against human immunodeficiency virus replication in vitro. J Acquir Immune Defic Syndr (1988). 1989;2(3):264-71.  [Content Brief]

  [2]. Yousef IM,et al. Lithocholate cholestasis--sulfated glycolithocholate-induced intrahepatic cholestasis in rats. Gastroenterology. 1981 Feb;80(2):233-41.  [Content Brief]