2. Anti-infection Metabolic Enzyme/Protease
  3. HIV Endogenous Metabolite
  4. Glycolithocholic acid 3-sulfate

Glycolithocholic acid 3-sulfate  (Synonyms: Glycolithocholate sulfate; Sulfolithocholylglycine; SLCG)

Cat. No.: HY-113074 Pureza: 99.21%
COA
SDS
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Glycolithocholic acid 3-sulfate (SLCG) is a cholic acid derivative and a metabolite of glycolithocholic acid. Glycolithocholic acid 3-sulfate inhibits replication of HIV-1 in vitro. Glycolithocholic acid 3-sulfate can be used for the research of HIV infection and gallbladder disease.

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Glycolithocholic acid 3-sulfate

Glycolithocholic acid 3-sulfate Estructura química

No. CAS : 15324-64-8

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Revisión del cliente

Based on 1 publication(s) in Google Scholar

Other Forms of Glycolithocholic acid 3-sulfate:

Glycolithocholic acid 3-sulfate Related Antibodies

Top Publications Citing Use of Products

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Human Endogenous Metabolite Microbial Metabolite

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Descripciòn

Glycolithocholic acid 3-sulfate (SLCG) is a cholic acid derivative and a metabolite of glycolithocholic acid. Glycolithocholic acid 3-sulfate inhibits replication of HIV-1 in vitro. Glycolithocholic acid 3-sulfate can be used for the research of HIV infection and gallbladder disease[1][2].

IC50 & Target

Microbial Metabolite

 

Cellular Effect
Cell Line Type Value Description References
HEK293 IC50
10 μM
Compound: Glycolithocholate-3-sulfate
TP_TRANSPORTER: inhibition of E217betaG uptake in membrane vesicles from MRP4-expressing HEK-293 cells
TP_TRANSPORTER: inhibition of E217betaG uptake in membrane vesicles from MRP4-expressing HEK-293 cells
[PMID: 12523936]
In Vitro

Glycolithocholic acid 3-sulfate (100 μg/mL) protects MT-4 cells against HIV-1-induced cytopathogenicity[1].
Glycolithocholic acid 3-sulfate (200 μg/mL) shows no toxicity for host cells[1].
Glycolithocholic acid 3-sulfate inhibits HIV-1 antigen expression in HIV-1-infected CEM cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Glycolithocholic acid 3-sulfate Related Antibodies
In Vivo

Glycolithocholic acid 3-sulfate (24 μmoL /100 g; i.v., once) induces intrahepatic cholestasis and increases biliary cholesterol secretion in male Wistar rats with bile fistula[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Wistar rats with bile fistula[2]
Dosage: 24 μmoL/100 g
Administration: Intravenous injection; 24 μmoL/100 g
Result: Induced intrahepatic cholestasis and increased biliary cholesterol secretion.
Peso molecular

513.69

Fòrmula

C26H43NO7S
No. CAS
Appearance

Solid

Color

White to off-white

SMILES

C[C@@]12[C@@]([H])(CC[C@@]2([C@@H](CCC(NCC(O)=O)=O)C)[H])[C@]3([C@]([H])(CC1)[C@@]4([C@]([H])(CC3)C[C@@H](CC4)OS(=O)(O)=O)C)[H]
Structure Classification
Initial Source
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvente y solubilidad
In Vitro: 

DMSO : 5 mg/mL (9.73 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.9467 mL 9.7335 mL 19.4670 mL
5 mM 0.3893 mL 1.9467 mL 3.8934 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Pureza y Documentación

Purity: 99.21%

SDS (252 KB)

COA (248 KB) HNMR (303 KB) LCMS (89 KB)

Instrucciones de manejo (2659 KB)
Referencias

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.9467 mL 9.7335 mL 19.4670 mL 48.6675 mL
5 mM 0.3893 mL 1.9467 mL 3.8934 mL 9.7335 mL
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Glycolithocholic acid 3-sulfate Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Glycolithocholic acid 3-sulfate15324-64-8Glycolithocholate Sulfolithocholylglycine SLCGHIVEndogenous MetaboliteHuman immunodeficiency viruscholic acid derivativeglycolithocholic acidgallbladder diseaseMT-4CEMratInhibitorinhibitorinhibit

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Nombre del producto:
Glycolithocholic acid 3-sulfate
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