Cat. No.: HY-N2581

Phytic acid sodium salt

(Synonyms: myo-Inositol, hexakisdihydrogen phosphate sodium salt; Inositol hexaphosphate sodium salt)

1 Cited Publications

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Based on 1 publication(s) in Google Scholar

Phytic acid (myo-Inositol; hexakis dihydrogen phosphate; Inositol hexaphosphate) sodium salt is an orally active compound. Phytic acid sodium salt can be derived from the seeds of legumes. Phytic acid sodium salt is a [PO4]³- storage depot and precursor for other inositol phosphates and pyrophosphates. Phytic acid sodium salt attenuates Aβ oligomers and upregulates autophagy protein. Phytic acid sodium salt can be used in cardiovascular disease, metabolic disease, nervous system disease and cancer research.

For research use only. We do not sell to patients.

Purity: 95.0%
CAS No.: 14306-25-3
Formula: C₆H₁₈O₂₄P₆.xNa

Storage:

4°C, sealed storage, away from moisture

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Phytic acid sodium salt Chemical Structure

CAS No.: 14306-25-3

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Publications (1)
Solvent & Solubility
- In Vitro
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target

IC50: precursor for inositol phosphates and pyrophosphates^[1]

All Endogenous Metabolite Isoforms :

In Vitro

Phytic acid (0.05%-0.4% (wt/wt), 5 min) sodium salt and sodium chloride show marked synergistic bactericidal effects against nonadapted and acid-adapted Escherichia coli O157:H7 strains^[2].
Phytic acid (1-5 mM, 2-3 h) sodium salt decreases the integrity of Caco-2 cell monolayers by modulating the TJ proteins' localization and down-regulating the expression levels of TJ proteins, and does not cause cytotoxicity to Caco-2 cells^[3].
Phytic acid (48-72 h) sodium salt provides complete protection against amyloid precursor protein-C-terminal fragment-induced cytotoxicity by attenuating levels of increased intracellular calcium, hydrogen peroxide, superoxide, Aβ oligomers, and moderately upregulated the expression of autophagy (beclin-1) protein in MC65 cells^[5].
Phytic acid (≥1 mM) sodium salt stimulates suicidal human erythrocyte death^[6].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[3]

Cell Line:

Caco-2
Concentration:

1, 2, 2.5, 3.5, 5 mM
Incubation Time:

3 h
Result:

Showed over 90% of the cells were viable when IP6 concentrations of 1-5 mM were used during the experiments.

In Vivo

Phytic acid (2%, diet, ad libitum for 21 d) sodium salt reduces growth performance of pigs partly through reduced capacity of the small intestine to absorb Na^[4].
Phytic acid (2%, drinking water, 6 months) sodium salt improves Alzheimer's pathology (AP180, beclin-1, LC3B, sirtuin 1) in Tg2576 mice^[5].
Phytic acid (20 mg/kg, i.p., pretreatment at 5 h before coronary artery occlusion) sodium salt suppresses ischemia-induced hydroxyl radical generation in rat myocardium^[7].
Phytic acid (100 mg/kg/d, gavage, five days a week, 8 weeks) sodium salt shows protective effects against CCl₄-induced liver fibrosis in mice^[8].
Phytic acid (4% of rodent chow, diet, 30 days) sodium salt reduces lipogenic enzyme activities in diabetic rats^[9].
Phytic acid (1-2 g/100 g, in water, 13 weeks) sodium salt shows anticarcinogenic effect in colon carcinoma rats, with 36% (1 g/100 g Phytic acid) and 42% (2 g/100 g Phytic acid) reduction in ACF, respectively^[10].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Piglets with an initial BW of 7.40 kg^[4]
Dosage:

2% (Phytic acid/food)
Administration:

diet, 21 days
Result:

Did not affect the blood plasma glucose and Na concentrations.
Reduced total potential difference and total short-circuit current.
Did not affect the blood plasma glucose and Na concentrations.
Did not affect the SGLT1 protein expression.

Chemical Information

CAS No. 14306-25-3
Appearance Solid
Formula C₆H₁₈O₂₄P₆.xNa
Color White to off-white
SMILES

O=P(O)(O)O[C@H]([C@H]([C@H](OP(O)(O)=O)[C@H]1OP(O)(O)=O)OP(O)(O)=O)[C@H]([C@H]1OP(O)(O)=O)OP(O)(O)=O.[x].[Na]
Synonyms

myo-Inositol, hexakisdihydrogen phosphate sodium salt; Inositol hexaphosphate sodium salt
Structure Classification
- Others
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Publications (1)

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SSRN

2022 Jan 26.

Solvent & Solubility

In Vitro:

H₂O : 100 mg/mL (ultrasonic and warming and heat to 41°C)

View the Complete Stock Solution Preparation Table

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (289 KB)
SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Shears SB, et al.Assessing the omnipotence of inositol hexakisphosphate.Cell Signal. 2001 Mar;13(3):151-8. [Content Brief]

[2]. Kim NH, et al. Phytic Acid and Sodium Chloride Show Marked Synergistic Bactericidal Effects against Nonadapted and Acid-Adapted Escherichia coli O157:H7 Strains. Appl Environ Microbiol. 2015 Dec 4;82(4):1040-1049. [Content Brief]

[3]. Fu Q, et al. The effect of phytic acid on tight junctions in the human intestinal Caco-2 cell line and its mechanism. Eur J Pharm Sci. 2015 Dec 1;80:1-8. [Content Brief]

[4]. Woyengo TA, et al. Effect of dietary phytic acid on performance and nutrient uptake in the small intestine of piglets. J Anim Sci. 2012 Feb;90(2):543-9. [Content Brief]

[5]. Anekonda TS, et al. Phytic acid as a potential treatment for alzheimer's pathology: evidence from animal and in vitro models. J Alzheimers Dis. 2011;23(1):21-35. [Content Brief]

[6]. Eberhard M, et al. Effect of phytic acid on suicidal erythrocyte death. J Agric Food Chem. 2010 Feb 10;58(3):2028-33. [Content Brief]

[7]. Obata T, et al. Phytic acid suppresses ischemia-induced hydroxyl radical generation in rat myocardium. Eur J Pharmacol. 2016 Mar 5;774:20-4. [Content Brief]

[8]. Xu Z, et al. Protective effects of phytic acid on CCl4‐induced liver fibrosis in mice. Journal of Food Biochemistry, 2023, 2023(1): 6634450.

[9]. Omoruyi FO, et al. The potential benefits and adverse effects of phytic Acid supplement in streptozotocin-induced diabetic rats. Adv Pharmacol Sci. 2013;2013:172494. [Content Brief]

[10]. Verghese M, et al. Anticarcinogenic effect of phytic acid (IP6): apoptosis as a possible mechanism of action. LWT-Food Science and Technology, 2006, 39(10): 1093-1098.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

Phytic acid sodium salt

1 Cited Publications

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Phytic acid sodium salt

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Publications Citing Use of MedChemExpress (MCE) Phytic acid sodium salt

All Endogenous Metabolite Isoforms

Biological Activity

Chemical Information

Publications (1)

Solvent & Solubility

Purity & Documentation

References

Calculators

Help & FAQs

Phytic acid sodium salt Related Classifications

HY-N2581 Related Classifications