Deoxycholic acid sodium hydrate
Based on 28 publication(s) in Google Scholar
Deoxycholic acid (cholanoic acid) sodium hydrate, a bile acid, is a by-product of intestinal metabolism, that activates the G protein-coupled bile acid receptorTGR5.
For research use only. We do not sell to patients.
- CAS No.: 145224-92-6
- Formula: C24H41NaO5
- Molecular Weight:432.57
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Publications Citing Use of MedChemExpress (MCE) Deoxycholic acid sodium hydrate
More- Nature. 2026 Mar;651(8104):251-259. [Abstract]
- Nature. 2025 Jul;643(8070):192-200. [Abstract]
- Cell Res. 2019 Mar;29(3):193-205. [Abstract]
- Cell Host Microbe. 2025 Aug 19:S1931-3128(25)00291-4. [Abstract]
- Cell Host Microbe. 2025 Jun 11;33(6):915-931.e9. [Abstract]
- Nat Cell Biol. 2018 Oct;20(10):1145-1158. [Abstract]
- Trends Biotechnol. 2026 Apr 15:S0167-7799(26)00130-7. [Abstract]
- Gut Microbes. 2025 Dec 31;17(1):2582944. [Abstract]
- Microbiome. 2019 Mar 20;7(1):43. [Abstract]
- Genes Dis. 2026 Jan 24.
- Adv Sci (Weinh). 2025 Mar;12(12):e2411719. [Abstract]
- Nat Cardiovasc Res. 2025 Apr 11. [Abstract]
- Adv Healthc Mater. 2026 Feb 21:e05684. [Abstract]
- Mater Today Bio. 2026 Feb 1:37:102843. [Abstract]
- Cell Death Discov. 2020 Jul 6:6:56. [Abstract]
- J Transl Med. 2024 Dec 20;22(1):1124. [Abstract]
- Chin Med J (Engl). 2025 Jun 16. [Abstract]
- Int J Biol Macromol. 2024 May;266(Pt 1):130939. [Abstract]
- Cell Rep. 2025 Sep 17;44(10):116306. [Abstract]
- J Invest Dermatol. 2022 May;142(5):1381-1390.e11. [Abstract]
- Cancer Cell Int. 2019 Jan 31:19:24. [Abstract]
- Biomedicines. 2025 Apr 4;13(4):874. [Abstract]
- Aquaculture. 2023 Sep 18, 740123.
- Microb Pathog. 2026 Jan:210:108187. [Abstract]
- Drug Metab Dispos. 2021 May;49(5):369-378. [Abstract]
- J Pharm Biomed Anal. 2025 Jul 15:259:116760. [Abstract]
- R Soc Open Sci. 2020 Jul 8;7(7):200635. [Abstract]
- Laurea Magistrale in Biomedical Engineering, Politecnico di Milano. 2019 Jun.
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Biological Activity
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Microbial Metabolite |
Deoxycholic acid sodium hydrate (DCA) (100 μM) induces the production of gastric cancer cell line MGC803 resistant to acidified bile acids and enhances their survival and proliferation activity under bile acid stress[2].
Deoxycholic acid sodium hydrate (DCA) (100 μM)-induced resistant cells shows altered morphology, significantly elevated telomerase activity, better cell viability and reduces apoptosis compared to normal MGC803 cells[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 145224-92-6
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Molecular Weight 432.57
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Formula C24H41NaO5
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SMILES
C[C@@]12[C@](CC[C@]2([H])[C@H](C)CCC(O[Na])=O)([H])[C@@]3([H])[C@@](C[C@@H]1O)([H])[C@@]4([C@](C[C@@H](CC4)O)([H])CC3)C.O
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Synonyms
Cholanoic Acid sodium hydrate; Desoxycholic acid sodium hydrate
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (28)
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Journal Impact Factor
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Most Recent
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Nature
2026 Mar;651(8104):251-259. PMID: 41606314 -
Nature
2025 Jul;643(8070):192-200. PMID: 39695227 -
Cell Res
Virus-induced accumulation of intracellular bile acids activates the TGR5-β-arrestin-SRC axis to enable innate antiviral immunity. [Abstract]2019 Mar;29(3):193-205. PMID: 30651583
Deoxycholic acid sodium hydrate purchased from MedChemExpress. Usage Cited in: Cell Res. 2019 Mar;29(3):193-205. [Abstract]
Virus-triggered accumulation of intracellular bile acids (BAs) promotes cellular antiviral response. Effects of BAs on virus-induced transcription of antiviral genes. Raw264.7 cells were infected with HSV-1 or SeV for 30 min and treated with Lithocholic acid (LCA) (0.1 mM), Chenodeoxycholic Acid (CDCA) (0.1 mM) or Deoxycholic acid (DCA) (0.1 mM) for 6 h before qPCR analysis of the indicated mRNA levels.
Deoxycholic acid sodium hydrate purchased from MedChemExpress. Usage Cited in: Cell Res. 2019 Mar;29(3):193-205. [Abstract]
Examination of intracellular bile acids (BA) levels after cells were treated with exogenous BAs. Raw264.7 cells were infected with HSV-1 or SeV for 30 min and treated with Lithocholic acid (LCA) (0.1 mM), Chenodeoxycholic Acid (CDCA) (0.1 mM) or Deoxycholic acid (DCA) (0.1 mM) for 6 h before BA assays were performed.
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Cell Host Microbe
2025 Aug 19:S1931-3128(25)00291-4. PMID: 40848719 -
Cell Host Microbe
Microbiota-derived urocanic acid triggered by tyrosine kinase inhibitors potentiates cancer immunotherapy efficacy. [Abstract]2025 Jun 11;33(6):915-931.e9. PMID: 40441145 -
Nat Cell Biol
Genome-wide screening of NEAT1 regulators reveals cross-regulation between paraspeckles and mitochondria. [Abstract]2018 Oct;20(10):1145-1158. PMID: 30250064 -
Trends Biotechnol
Engineering Bacillus subtilis as a sustainable platform for the production of functional bile acids. [Abstract]2026 Apr 15:S0167-7799(26)00130-7. PMID: 41991462 -
Gut Microbes
Antibiotic cocktail-induced changes in gut microbiota drive alteration of bile acid metabolism to restrain Th17 differentiation through the FXR-NLRP3 axis. [Abstract]2025 Dec 31;17(1):2582944. PMID: 41305918 -
Microbiome
Species-specific enhancement of enterohemorrhagic E. coli pathogenesis mediated by microbiome metabolites. [Abstract]2019 Mar 20;7(1):43. PMID: 30890187 -
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Adv Sci (Weinh)
Targeting FDFT1 Reduces Cholesterol and Bile Acid Production and Delays Hepatocellular Carcinoma Progression Through the HNF4A/ALDOB/AKT1 Axis. [Abstract]2025 Mar;12(12):e2411719. PMID: 39899681
Deoxycholic acid sodium hydrate purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2025 Mar;12(12):e2411719. [Abstract]
The mRNA levels of ALDOB in Huh7 or HCCLM3 cells treated with various bile acids (100 μM, 24 h). All data are presented as mean ± SD. Data were analyzed by one-way ANOVA with Bonferroni multiple-comparison correction. CA, cholic acid; TCA, taurocholic acid; GCA, glycocholic acid; TCDCA, taurochenodeoxycholic acid; GCDCA, glycochenodeoxycholic acid; LCA, lithocholic acid; TLCA, taurolithocholic acid; GLCA, glycolithocholic acid; DCA, deoxycholic acid; TDCA, taurodeoxycholic acid; GDCA, glycodeoxycholic acid; UDCA, ursodeoxycholic acid; TUDCA, tauroursodeoxycholic acid; GUDCA, glycoursodeoxycholic acid.
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Nat Cardiovasc Res
The gut microbiota-bile acid-TGR5 axis orchestrates platelet activation and atherothrombosis. [Abstract]2025 Apr 11. PMID: 40217125 -
Adv Healthc Mater
An Injectable Liposome-Hydrogel Composite for Targeted Delivery of a Non-Lactylated Peptide to Rebalance Bone Metabolism in Hyperlipidemia. [Abstract]2026 Feb 21:e05684. PMID: 41721628 -
Mater Today Bio
Living bacterial reactor potently activates tumor immunogenic ferroptosis via cysteine depletion and photothermal therapy. [Abstract]2026 Feb 1:37:102843. PMID: 41704298 -
Cell Death Discov
TGR5-HNF4α axis contributes to bile acid-induced gastric intestinal metaplasia markers expression. [Abstract]2020 Jul 6:6:56. PMID: 32655894 -
J Transl Med
Conjugated bile acids alleviate acute pancreatitis through inhibition of TGR5 and NLRP3 mediated inflammation. [Abstract]2024 Dec 20;22(1):1124. PMID: 39707318 -
Chin Med J (Engl)
2025 Jun 16. PMID: 40518567 -
Int J Biol Macromol
2024 May;266(Pt 1):130939. PMID: 38493816 -
Cell Rep
Multilevel regulation of c-di-GMP biosynthesis by cAMP signaling increases Shigella sonnei fitness and pathogenicity in response to bile salts. [Abstract]2025 Sep 17;44(10):116306. PMID: 40966079 -
J Invest Dermatol
Bile Acids Improve Psoriasiform Dermatitis through Inhibition of IL-17A Expression and CCL20-CCR6-Mediated Trafficking of T Cells. [Abstract]2022 May;142(5):1381-1390.e11. PMID: 34808237 -
Cancer Cell Int
SOX2 interferes with the function of CDX2 in bile acid-induced gastric intestinal metaplasia. [Abstract]2019 Jan 31:19:24. PMID: 30733645
Deoxycholic acid sodium hydrate purchased from MedChemExpress. Usage Cited in: Cancer Cell Int. 2019 Jan 31:19:24. [Abstract]
The expression of CDX2, KLF4, HNF4α, and cadherin 17 is increased upon stimulation with DCA in a dose-dependent manner.
Deoxycholic acid sodium hydrate purchased from MedChemExpress. Usage Cited in: Cancer Cell Int. 2019 Jan 31:19:24. [Abstract]
The expression of CDX2, KLF4, HNF4α, and cadherin 17 is increased upon stimulation with DCA in a dose-dependent manner.
Deoxycholic acid sodium hydrate purchased from MedChemExpress. Usage Cited in: Cancer Cell Int. 2019 Jan 31:19:24. [Abstract]
Western blotting results indicated that the inhibition of SOX2 in bile acid-treated AGS cells is partially rescued in miR-21 knockdown AGS cells.
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Biomedicines
2025 Apr 4;13(4):874. PMID: 40299495 -
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Microb Pathog
Lithocholic acid exerts antiviral activity against porcine epidemic diarrhea virus by enhancing TGR5-mediated type III interferon production. [Abstract]2026 Jan:210:108187. PMID: 41242567 -
Drug Metab Dispos
2021 May;49(5):369-378. PMID: 33674269 -
J Pharm Biomed Anal
Integrating 16S rDNA sequencing analysis and targeted metabolomics to explore the mechanism of Xiexin Tang in treating atherosclerosis mice induced by high-fat diet. [Abstract]2025 Jul 15:259:116760. PMID: 40014894 -
R Soc Open Sci
Ultra-performance liquid chromatography-tandem mass spectrometric method for quantitation of the recently Food and Drug Administration approved combination of vaborbactam and meropenem in human plasma. [Abstract]2020 Jul 8;7(7):200635. PMID: 32874656 -
Purity & Documentation
References
[1]. Somm E, et al. β-Klotho deficiency protects against obesity through a crosstalk between liver, microbiota, and brown adipose tissue. JCI Insight. 2017 Apr 20;2(8). pii: 91809. [Content Brief]
[2]. Wang X, et al. Acidified bile acids enhance tumor progression and telomerase activity of gastric cancer in micedependent on c-Myc expression. Cancer Med. 2017 Apr;6(4):788-797. [Content Brief]
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