1. Metabolic Enzyme/Protease
    GPCR/G Protein
  2. Endogenous Metabolite
    G protein-coupled Bile Acid Receptor 1
  3. Deoxycholic acid sodium hydrate

Deoxycholic acid sodium hydrate (Synonyms: Cholanoic Acid sodium hydrate; Desoxycholic acid sodium hydrate)

Cat. No.: HY-N0593B
Handling Instructions

Deoxycholic acid (cholanoic acid) sodium hydrate,a bile acid, is a by-product of intestinal metabolism, that activates the G protein-coupled bile acid receptorTGR5.

For research use only. We do not sell to patients.

Deoxycholic acid sodium hydrate Chemical Structure

Deoxycholic acid sodium hydrate Chemical Structure

CAS No. : 145224-92-6

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Top Publications Citing Use of Products

    Deoxycholic acid sodium hydrate purchased from MCE. Usage Cited in: Cancer Cell Int. 2019 Jan 31;19:24.

    The expression of CDX2, KLF4, HNF4α, and cadherin 17 is increased upon stimulation with DCA in a dose-dependent manner.

    Deoxycholic acid sodium hydrate purchased from MCE. Usage Cited in: Cancer Cell Int. 2019 Jan 31;19:24.

    The expression of CDX2, KLF4, HNF4α, and cadherin 17 is increased upon stimulation with DCA in a dose-dependent manner.

    Deoxycholic acid sodium hydrate purchased from MCE. Usage Cited in: Cancer Cell Int. 2019 Jan 31;19:24.

    Western blotting results indicated that the inhibition of SOX2 in bile acid-treated AGS cells is partially rescued in miR-21 knockdown AGS cells.
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    Description

    Deoxycholic acid (cholanoic acid) sodium hydrate,a bile acid, is a by-product of intestinal metabolism, that activates the G protein-coupled bile acid receptorTGR5[1][2].

    IC50 & Target

    Microbial Metabolite

     

    In Vitro

    Deoxycholic acid sodium hydrate (DCA) (100 μM) induces the production of gastric cancer cell line MGC803 resistant to acidified bile acids and enhances their survival and proliferation activity under bile acid stress[2].
    Deoxycholic acid sodium hydrate (DCA) (100 μM)-induced resistant cells shows altered morphology, significantly elevated telomerase activity, better cell viability and reduces apoptosis compared to normal MGC803 cells[2].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Molecular Weight

    432.57

    Formula

    C24H41NaO5

    CAS No.
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    Shipping

    Room temperature in continental US; may vary elsewhere.

    Storage

    Please store the product under the recommended conditions in the Certificate of Analysis.

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    References
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    Product Name:
    Deoxycholic acid sodium hydrate
    Cat. No.:
    HY-N0593B
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