Deoxycholic acid-d4
Based on 1 publication(s) in Google Scholar
Deoxycholic acid-d4 is the deuterium labeled Deoxycholic acid. Deoxycholic acid is specifically responsible for activating the G protein-coupled bile acid receptor TGR5 that stimulates brown adipose tissue (BAT) thermogenic activity.
For research use only. We do not sell to patients.
- Purity: 99.80%
- CAS No.: 112076-61-6
- Formula: C24H36D4O4
- Molecular Weight:396.60
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Deoxycholic acid-d4
MoreAll Endogenous Metabolite Isoforms
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Biological Activity
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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CAS No. 112076-61-6
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Unlabeled Cas 83-44-3
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Appearance Solid
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Molecular Weight 396.60
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Formula C24H36D4O4
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Color White to off-white
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SMILES
O[C@@H]1C([2H])(C[C@]2([C@@]([H])(C1([2H])[2H])CC[C@@]3([C@@]2(C[C@@H]([C@]4([C@]3(CC[C@@]4([C@@H](CCC(O)=O)C)[H])[H])C)O)[H])[H])C)[2H]
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (1)
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Journal Impact Factor
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Most Recent
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J Vet Intern Med
Efficacy of Urine Asymmetric Dimethylarginine Concentration to Predict Azotemia in Hyperthyroid Cats After Radio-Iodine Treatment. [Abstract]2025 May-Jun;39(3):e70096. PMID: 40271736
Solvent & Solubility
DMSO : 100 mg/mL (252.14 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (275 KB)
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SDS (739 KB)
- English - EN (739 KB)
- Français - FR (739 KB)
- Deutsch - DE (739 KB)
- Norwegian - NO (739 KB)
- Español - ES (739 KB)
- Swedish - SV (739 KB)
- Italian - IT (739 KB)
- Portuguese - PT (739 KB)
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Handling Instructions (2659 KB)
References
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]
[2]. Somm E, et al. β-Klotho deficiency protects against obesity through a crosstalk between liver, microbiota, and brown adipose tissue. JCI Insight. 2017 Apr 20;2(8). pii: 91809. [Content Brief]
[3]. Wang X, et al. Acidified bile acids enhance tumor progression and telomerase activity of gastric cancer in micedependent on c-Myc expression. Cancer Med. 2017 Apr;6(4):788-797. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.5214 mL | 12.6072 mL | 25.2143 mL | 63.0358 mL |
| 5 mM | 0.5043 mL | 2.5214 mL | 5.0429 mL | 12.6072 mL | |
| 10 mM | 0.2521 mL | 1.2607 mL | 2.5214 mL | 6.3036 mL | |
| 15 mM | 0.1681 mL | 0.8405 mL | 1.6810 mL | 4.2024 mL | |
| 20 mM | 0.1261 mL | 0.6304 mL | 1.2607 mL | 3.1518 mL | |
| 25 mM | 0.1009 mL | 0.5043 mL | 1.0086 mL | 2.5214 mL | |
| 30 mM | 0.0840 mL | 0.4202 mL | 0.8405 mL | 2.1012 mL | |
| 40 mM | 0.0630 mL | 0.3152 mL | 0.6304 mL | 1.5759 mL | |
| 50 mM | 0.0504 mL | 0.2521 mL | 0.5043 mL | 1.2607 mL | |
| 60 mM | 0.0420 mL | 0.2101 mL | 0.4202 mL | 1.0506 mL | |
| 80 mM | 0.0315 mL | 0.1576 mL | 0.3152 mL | 0.7879 mL | |
| 100 mM | 0.0252 mL | 0.1261 mL | 0.2521 mL | 0.6304 mL |
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