83-44-3
83-44-3
Chemical Structure
Deoxycholic acid
Synonym(s): Cholanoic acid; Desoxycholic acid
- CAS No.: 83-44-3
- Formula:C24H40O4
- Molecular Weight:392.57
IUPAC Name: (R)-4-((3R,5R,8R,9S,10S,12S,13R,14S,17R)-3,12-dihydroxy-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)pentanoic acid
InChIKey: KXGVEGMKQFWNSR-LLQZFEROSA-N
SMILES: C[C@@]1([C@@]2([H])[C@H](C)CCC(O)=O)[C@](CC2)([H])[C@@](CC[C@@]3([H])[C@@]4(CC[C@@H](O)C3)C)([H])[C@]4([H])C[C@@H]1O
Biological Activity: Deoxycholic acid (cholanoic acid), a bile acid, is a by-product of intestinal metabolism, that activates the G protein-coupled bile acid receptorTGR5[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Deoxycholic acid | 99.94% | Deoxycholic acid (cholanoic acid), a bile acid, is a by-product of intestinal metabolism, that activates the G protein-coupled bile acid receptorTGR5. | ||||||||||||||||||||
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Deoxycholic acid (Standard) | 99.85% | Deoxycholic acid (Standard) is the analytical standard of Deoxycholic acid. This product is intended for research and analytical applications. Deoxycholic acid (cholanoic acid), a bile acid, is a by-product of intestinal metabolism, that activates the G protein-coupled bile acid receptorTGR5. | ||||||||||||||||||||
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Deoxycholic acid-d5 | 99.9% | Deoxycholic acid-d5 is the deuterium labeled Deoxycholic acid. Deoxycholic acid is specifically responsible for activating the G protein-coupled bile acid receptor TGR5 that stimulates brown adipose tissue (BAT) thermogenic activity. | ||||||||||||||||||||
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Deoxycholic acid-d4 | 99.80% | Deoxycholic acid-d4 is the deuterium labeled Deoxycholic acid. Deoxycholic acid is specifically responsible for activating the G protein-coupled bile acid receptor TGR5 that stimulates brown adipose tissue (BAT) thermogenic activity. | ||||||||||||||||||||
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Deoxycholic acid-d6 | 99.7% | Deoxycholic acid-d6 is the deuterium labeled Deoxycholic acid. Deoxycholic acid is specifically responsible for activating the G protein-coupled bile acid receptor TGR5 that stimulates brown adipose tissue (BAT) thermogenic activity. | ||||||||||||||||||||
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Deoxycholic acid-13C | 98.0% | Deoxycholic acid-13C is the 13C-labeled Deoxycholic acid. Deoxycholic acid is specifically responsible for activating the G protein-coupled bile acid receptor TGR5 that stimulates brown adipose tissue (BAT) thermogenic activity. | ||||||||||||||||||||
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Ursodeoxycholic acid-d4 | 99.52% | Ursodeoxycholic acid-2,2,4,4-d4 is the deuterium labeled Ursodeoxycholic acid (HY-13771). Ursodeoxycholic acid is a secondary bile acid issued from the transformation of (cheno)deoxycholic acid by intestinal bacteria, acting as a key regulator of the intestinal barrier integrity and essential for lipid metabolism. Ursodeoxycholic acid acts as signaling molecule, exerting its effects by interacting with bile acid activated receptors, including G-protein coupled bile acid receptor 5 (TGR5, GPCR19) and the farnesoid X receptor (FXR). Ursodeoxycholic acid can be used for the research of a variety of hepatic and gastrointestinal diseases. Ursodeoxycholic acid also reduces ACE2 expression and is beneficial for reducing SARS-CoV-2 infection. | ||||||||||||||||||||
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Glycodeoxycholic acid-d4 | 99.78% | Glycodeoxycholic acid-d4 is the deuterium labeled Glycodeoxycholic Acid. Glycodeoxycholic Acid is an endogenous metabolite. | ||||||||||||||||||||
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6-ECDCA-d4 | 6-ECDCA-d4 (6α-ethyl Cheodeoxycholic Acid-d4, Obeticholic Acid-d4) is deuterium labeled 6-ECDCA. | |||||||||||||||||||||
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Methyl desoxycholate | 98.0% | Methyl desoxycholate is an ester product. | ||||||||||||||||||||
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3α,12β-Dihydroxycholanoic acid | 97.0% | 3α,12β-Dihydroxycholanoic acid is a dihydroxy bile acid that is detectable in healthy urine samples. 3α,12β-Dihydroxycholanoic acid carries hydroxy substituents at the 3α and 12β positions of the 5β-cholanoic acid steroid skeleton. | ||||||||||||||||||||
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3α,12β-Dihydroxycholanoic acid (Standard) | ≥98% | 3α,12β-Dihydroxycholanoic acid (Standard) is the analytical standard of 3α,12β-Dihydroxycholanoic acid (HY-43470). This product is intended for research and analytical applications. 3α,12β-Dihydroxycholanoic acid is a dihydroxy bile acid that is detectable in healthy urine samples. 3α,12β-Dihydroxycholanoic acid carries hydroxy substituents at the 3α and 12β positions of the 5β-cholanoic acid steroid skeleton. | ||||||||||||||||||||
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(R)-Ethyl 4-((3R,5R,8R,9S,10S,12S,13R,14S,17R)-3,12-dihydroxy-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)pentanoate (Standard) | ≥98% | |||||||||||||||||||||
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3-Epideoxycholic acid | 99.90% | 3-Epideoxycholic acid is a secondary bile acid and a microbial metabolite of Deoxycholic acid (HY-N0593). 3-Epideoxycholic acid targets FXR in dendritic cells, reduces their immunostimulatory properties, promotes the generation of Treg cells, and exerts anti-inflammatory activity. 3-Epideoxycholic acid can promote the growth of the bacterium Bacteroides. 3-Epideoxycholic acid can be used in research related to inflammatory and immune diseases as well as bacterial infections. | ||||||||||||||||||||
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Chenodeoxycholic Acid-d4 | 99.94% | Chenodeoxycholic Acid-d4 is the deuterium labeled Chenodeoxycholic Acid. Chenodeoxycholic Acid is a hydrophobic primary bile acid that activates nuclear receptors (FXR) involved in cholesterol metabolism. | ||||||||||||||||||||
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Isoallolithocholic acid-d4 | Isoallolithocholic acid-d4 (3β-Hydroxy-5α-cholanic acid-d4) is deuterium labeled Isoallolithocholic acid. Isoallolithocholic acid (3β-Hydroxy-5α-cholanic acid), a derivative of Lithocholic acid (HY-10219), is a T cell regulator. Isoallolithocholic acid enhances regulatory T cells (Tregs) differentiation. | |||||||||||||||||||||
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Lithocholic acid-d4 | 99.91% | Lithocholic acid-d4 is the deuterium labeled Lithocholic acid, which is a toxic secondary bile acid. | ||||||||||||||||||||
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Cholic acid-d4 | 99.91% | Cholic acid-d4 is the deuterium labeled Cholic acid. Cholic acid is a major primary bile acid produced in the liver and usually conjugated with glycine or taurine. It facilitates fat absorption and cholesterol excretion. | ||||||||||||||||||||
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Cholic acid-d5 | 99.80% | Cholic acid-d5 is the deuterium labeled Cholic acid. Cholic acid is a major primary bile acid produced in the liver and usually conjugated with glycine or taurine. It facilitates fat absorption and cholesterol excretion. | ||||||||||||||||||||
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Deoxycholic acid sodium salt (Standard) | 98.88% | Deoxycholic acid sodium salt (Standard) is the analytical standard of Deoxycholic acid sodium salt. This product is intended for research and analytical applications. Deoxycholic acid sodium salt (sodium deoxycholate), a bile acid, is a by-product of intestinal metabolism, that activates the G protein-coupled bile acid receptorTGR5. | ||||||||||||||||||||
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Deoxycholic acid sodium hydrate | Deoxycholic acid (cholanoic acid) sodium hydrate, a bile acid, is a by-product of intestinal metabolism, that activates the G protein-coupled bile acid receptorTGR5. | |||||||||||||||||||||
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3α,12α-Dihydroxy-5β-cholestanoic acid | 3α,12α-Dihydroxy-5β-cholestanoic acid is a cholestenoic acid. | |||||||||||||||||||||
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Nordeoxycholic acid | 99.90% | Nordeoxycholic acid (3α,12α-Dihydroxynorcholanic acid) is an orally active hydrophobic bile acid metabolite. Nordeoxycholic acid inhibits autophagic flux, induces endoplasmic reticulum stress and causes hepatocyte injury. Nordeoxycholic acid impairs intestinal barrier integrity in mice. Nordeoxycholic acid can be used in the research of alcohol-associated liver disease. | ||||||||||||||||||||
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Nordeoxycholic acid (Standard) | ≥98% | Nordeoxycholic acid (3α,12α-Dihydroxynorcholanic acid) (Standard) is the analytical standard of Nordeoxycholic acid (HY-N8268). This product is intended for research and analytical applications. Nordeoxycholic acid is an orally active hydrophobic bile acid metabolite. Nordeoxycholic acid inhibits autophagic flux, induces endoplasmic reticulum stress and causes hepatocyte injury. Nordeoxycholic acid impairs intestinal barrier integrity in mice. Nordeoxycholic acid can be used in the research of alcohol-associated liver disease. | ||||||||||||||||||||
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Allodeoxycholic acid | Allodeoxycholic acid is a nucleoside metabolite. | |||||||||||||||||||||
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References
- [1]. Somm E, et al. β-Klotho deficiency protects against obesity through a crosstalk between liver, microbiota, and brown adipose tissue. JCI Insight. 2017 Apr 20;2(8). pii: 91809. [Content Brief]
- [2]. Wang X, et al. Acidified bile acids enhance tumor progression and telomerase activity of gastric cancer in micedependent on c-Myc expression. Cancer Med. 2017 Apr;6(4):788-797. [Content Brief]
