2. Metabolic Enzyme/Protease
  3. Pyruvate Kinase
  4. PKM2 activator 2

PKM2 activator 2 

Cat. No.: HY-147368 Purity: 99.48%
COA Handling Instructions

PKM2 activator 2 is a pyruvate kinase M2 (PKM2) activitor with an AC50 value of 66 nM. PKM2 activator 2 may show anti-tumor proliferation effect and relieve the Warburg effect, while PKM2 activation can restore normal glycolytic metabolism in cells.

For research use only. We do not sell to patients.

PKM2 activator 2 Chemical Structure

PKM2 activator 2 Chemical Structure

CAS No. : 1186660-06-9

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10 mM * 1 mL in DMSO USD 165 In-stock
Estimated Time of Arrival: December 31
Solid
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Based on 1 publication(s) in Google Scholar

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Description

PKM2 activator 2 is a pyruvate kinase M2 (PKM2) activitor with an AC50 value of 66 nM. PKM2 activator 2 may show anti-tumor proliferation effect and relieve the Warburg effect, while PKM2 activation can restore normal glycolytic metabolism in cells[1].

IC50 & Target

PKM2

66 nM (EC50)

In Vitro

PKM2 leads to increased availability of glycolyctic intermediates for biosynthesis of amino acids, nucleic acids, and lipid building blocks for cellular construction in cancer cells. However, PKM2 shows down-regulated expression and dimeric form in tumors and cancer cell lines [1].
PKM2 activator 2 (compound 28) is a highly potent activator, activates pyruvate kinase with an AC50 value of 66 nM in the luciferase-coupled assay[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

452.49

Appearance

Solid

Formula

C20H18F2N2O4S2
CAS No.
SMILES

FC1=C(S(=O)(N2CCN(S(=O)(C3=CC4=C(C=CC=C4)C=C3)=O)CC2)=O)C(F)=CC=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Purity & Documentation
References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Keywords:

PKM2 activator 21186660-06-9Pyruvate KinaseWarburg effect2-napthyl and 6-(2,2-dimethylchroman) derivativesglycolytic metabolism，dimeric form，glycolyctic intermediatesamino acidsnucleic acidslipid building blockscellular constructionanti-proliferationInhibitorinhibitorinhibit

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