1. GPCR/G Protein
  2. Prostaglandin Receptor
  3. CAY10580

CAY10580 

Cat. No.: HY-135259
Handling Instructions

CAY10580 is a potent and selective prostaglandin EP4 receptor agonist (Ki=35 nM).

For research use only. We do not sell to patients.

CAY10580 Chemical Structure

CAY10580 Chemical Structure

CAS No. : 64054-40-6

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Description

CAY10580 is a potent and selective prostaglandin EP4 receptor agonist (Ki=35 nM)[1].

IC50 & Target[1]

EP4

35 nM (Ki)

EP4 Receptor

35 nM (Ki)

EP2 Receptor

3000 nM (Ki)

EP3 receptor

2000 nM (Ki)

In Vitro

CAY10580 (10-10000 nM; 40 min) significantly increases apical membrane abundance of AQP2 in MDCK cells at 100 to 10000 nM[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

CAY10580 (200 μg/kg body weight; i.p; daily for three weeks) effectively prevents diet-induced hypercholesterolemia, enhances endogenous bile acid synthesis and their fecal excretion[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Six-week old male EP4+/+ mice (Treating high fat diet-challenged mice)[3]
Dosage: 200 μg/kg body weight
Administration: Intraperitoneal injection; daily for remaining three weeks
Result: High fat diet fed mice exhibited lower total cholesterol levels compared to the vehicle group by 28.5%. Total cholesterol levels decreased from 137.4 to 98.2 mg/dl, restoring plasma cholesterol back to near-normal values.
Molecular Weight

341.49

Formula

C₁₉H₃₅NO₄

CAS No.
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Solution, -20°C, 2 years

References
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CAY10580
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