CAY10580
Based on 1 Customer Validation
CAY10580 is a potent and selective prostaglandin EP4 receptor agonist (Ki=35 nM).
For research use only. We do not sell to patients.
- Purity : 97.4%
- CAS No.: 64054-40-6
- Formula: C19H35NO4
- Molecular Weight:341.49
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Storage:
Solution, -20°C, 2 years
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
IC50 & Target
[1]|
EP4 35 nM (Ki) |
EP2 3000 nM (Ki) |
EP3 2000 nM (Ki) |
EP1 >3000 nM (Ki) |
In Vitro
CAY10580 (10-10000 nM; 40 min) significantly increases apical membrane abundance of AQP2 in MDCK cells at 100 to 10000 nM[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Six-week old male EP4+/+ mice (Treating high fat diet-challenged mice)[3]
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Dosage:200 μg/kg body weight
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Administration:Intraperitoneal injection; daily for remaining three weeks
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Result:High fat diet fed mice exhibited lower total cholesterol levels compared to the vehicle group by 28.5%. Total cholesterol levels decreased from 137.4 to 98.2 mg/dl, restoring plasma cholesterol back to near-normal values.
Chemical Information
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CAS No. 64054-40-6
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Appearance Liquid
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Molecular Weight 341.49
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Formula C19H35NO4
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Color Colorless to light yellow
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SMILES
O=C(O)CCCCCCN1C(CCC(O)CCCCC)CCC1=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Solution, -20°C, 2 years
Purity & Documentation
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Data Sheet (272 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
[1]. Billot X, et al. Discovery of a potent and selective agonist of the prostaglandin EP4 receptor. Bioorg Med Chem Lett. 2003;13(6):1129-1132. [Content Brief]
[2]. Olesen ET, et al. Vasopressin-independent targeting of aquaporin-2 by selective E-prostanoid receptor agonists alleviates nephrogenic diabetes insipidus. Proc Natl Acad Sci U S A. 2011;108(31):12949-12954. [Content Brief]
[3]. Ying F, et al. EP4 emerges as a novel regulator of bile acid synthesis and its activation protects against hypercholesterolemia. Biochim Biophys Acta Mol Cell Biol Lipids. 2018;1863(9):1029-1040. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
CAY10580 Related Classifications
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