1. Immunology/Inflammation
    Metabolic Enzyme/Protease
  2. Aryl Hydrocarbon Receptor
    Endogenous Metabolite
  3. D-Kynurenine

D-Kynurenine 

Cat. No.: HY-W014502 Purity: 98.84%
Handling Instructions

D-kynurenine, a metabolite of D-tryptophan, can serve as the bioprecursor of kynurenic acid (KYNA) and 3-hydroxykynurenine. D-Kynurenine is an agonist for G protein-coupled receptor, GPR109B. D-Kynurenine is a substrate in a fluorometric assay of D-amino acid oxidase. D-kynurenine promotes epithelial-to-mesenchymal transition via activating aryl hydrocarbon receptor (AHR).

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D-Kynurenine Chemical Structure

D-Kynurenine Chemical Structure

CAS No. : 13441-51-5

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Description

D-kynurenine, a metabolite of D-tryptophan, can serve as the bioprecursor of kynurenic acid (KYNA) and 3-hydroxykynurenine. D-Kynurenine is an agonist for G protein-coupled receptor, GPR109B. D-Kynurenine is a substrate in a fluorometric assay of D-amino acid oxidase. D-kynurenine promotes epithelial-to-mesenchymal transition via activating aryl hydrocarbon receptor (AHR)[1][2][3][4].

IC50 & Target[1]

Human Endogenous Metabolite

 

In Vitro

D-kynurenine (10, 40, 60, and 100 µM) positively regulates the metastasis of 95D cells, a lung cancer cell line, which is reduced upon siRNAAhr treatment. Significant enhancement VIM expression was detected in the presence of D-kynurenine (10 and 40 µM). 10 µM D-kynurenine markedly attenuates E-cadherin level. 10 µM D-kynurenine-mediated changes of VIM and E-cadherin are substantially attenuated on siRNAAhr treatment as well. The evidences-10/40 µM D-kynurenine-induced up-regulation of CYP1A1, 10 µM D-kynurenine-induced increase of nuclear transfer of Ahr, and 10/40/60/100 µM D-kynurenine-induced enhancement of DER-luciferase activity-indicated that D-kynurenine Is capable of activating Ahr in fact[4].

Molecular Weight

208.21

Formula

C₁₀H₁₂N₂O₃

CAS No.

13441-51-5

SMILES

O=C(C(C=CC=C1)=C1N)C[[email protected]@H](N)C(O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

H2O : 62.5 mg/mL (300.18 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.8028 mL 24.0142 mL 48.0284 mL
5 mM 0.9606 mL 4.8028 mL 9.6057 mL
10 mM 0.4803 mL 2.4014 mL 4.8028 mL
*Please refer to the solubility information to select the appropriate solvent.
References
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Keywords:

D-KynurenineAryl Hydrocarbon ReceptorEndogenous MetaboliteAhRbioprecursorGPR109BsubstrateD-aminoacidoxidaseAHRInhibitorinhibitorinhibit

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D-Kynurenine
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