1. Membrane Transporter/Ion Channel
    Neuronal Signaling
  2. Calcium Channel
  3. Ned-K

Ned-K 

Cat. No.: HY-131041
Handling Instructions

Ned-K is a nicotinic acid adenine dinucleotide phosphate (NAADP) antagonist. Ned-K is effective at dampening simulated ischaemia and reperfusion (sIR)-induced Ca2+ oscillations in cardiomyocytes.

For research use only. We do not sell to patients.

Ned-K Chemical Structure

Ned-K Chemical Structure

CAS No. : 2250019-90-8

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Description

Ned-K is a nicotinic acid adenine dinucleotide phosphate (NAADP) antagonist. Ned-K is effective at dampening simulated ischaemia and reperfusion (sIR)-induced Ca2+ oscillations in cardiomyocytes[1].

In Vitro

Ned-K suppresses Ca2+ oscillations and dramatically protects cardiomyocytes from cell death in vitro after ischaemia and reoxygenation, preventing opening of the mitochondrial permeability transition pore. Ned-K (10 µM) almost completely eliminates [Ca2+]c oscillations, and Ned-K (0.1 µM) is effective at suppressing [Ca2+]c levels[1].

Cell Viability Assay[1]

Cell Line: Dead primary adult cardiomyocytes
Concentration: 0.1 and 10 µM
Incubation Time:
Result: Treatment with 0.1 µM caused a slight decrease in cardiomyocyte death (34±6%).
Treatment with 10 μM at reoxygenation significantly decreased cell death after sIR to 16±1%.
In Vivo

Injection of Ned-K causes a significant reduction in infarct size in mice. Ned-K (administered i.v. to mice 5 min before reperfusion) significantly decreases myocardial infarct size relative to area at risk[1].

Molecular Weight

521.61

Formula

C₃₁H₃₁N₅O₃

CAS No.

2250019-90-8

SMILES

O=C([[email protected]]1N[[email protected]@H](C2=C(C1)C3=C(N2)C=CC=C3)C4=CC=C(C(CN5CCN(CC5)C6=CC=CC=C6C#N)=C4)OC)O

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Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

Ned-KCalcium ChannelCa2+ channelsCa channelsnicotinicacidadeninedinucleotidephosphateNAADPischaemiareperfusionCa2+oscillationcardiomyocytesInhibitorinhibitorinhibit

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Ned-K
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