2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. Calcium Channel
  4. Ned-K

Ned-K is a nicotinic acid adenine dinucleotide phosphate (NAADP) antagonist. Ned-K is effective at dampening simulated ischaemia and reperfusion (sIR)-induced Ca2+ oscillations in cardiomyocytes.

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Ned-K Chemical Structure

Ned-K Chemical Structure

CAS No. : 2250019-90-8

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Ned-K Related Antibodies

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Description

Ned-K is a nicotinic acid adenine dinucleotide phosphate (NAADP) antagonist. Ned-K is effective at dampening simulated ischaemia and reperfusion (sIR)-induced Ca2+ oscillations in cardiomyocytes[1].

In Vitro

Ned-K suppresses Ca2+ oscillations and dramatically protects cardiomyocytes from cell death in vitro after ischaemia and reoxygenation, preventing opening of the mitochondrial permeability transition pore. Ned-K (10 µM) almost completely eliminates [Ca2+]c oscillations, and Ned-K (0.1 µM) is effective at suppressing [Ca2+]c levels[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Ned-K Related Antibodies

Cell Viability Assay[1]

Cell Line: Dead primary adult cardiomyocytes
Concentration: 0.1 and 10 µM
Incubation Time:
Result: Treatment with 0.1 µM caused a slight decrease in cardiomyocyte death (34±6%).
Treatment with 10 μM at reoxygenation significantly decreased cell death after sIR to 16±1%.
In Vivo

Injection of Ned-K causes a significant reduction in infarct size in mice. Ned-K (administered i.v. to mice 5 min before reperfusion) significantly decreases myocardial infarct size relative to area at risk[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

521.61

Formula

C31H31N5O3
CAS No.
SMILES

O=C([C@H]1N[C@@H](C2=C(C1)C3=C(N2)C=CC=C3)C4=CC=C(C(CN5CCN(CC5)C6=CC=CC=C6C#N)=C4)OC)O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Ned-K Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Ned-K2250019-90-8Calcium ChannelCa2+ channelsCa channelsnicotinicacidadeninedinucleotidephosphateNAADPischaemiareperfusionCa2+oscillationcardiomyocytesInhibitorinhibitorinhibit

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