1. Metabolic Enzyme/Protease
    Apoptosis
  2. Endogenous Metabolite
    Apoptosis
  3. L-Cystathionine

L-Cystathionine 

Cat. No.: HY-W009749 Purity: ≥99.0%
Handling Instructions

L-Cystathionine is a nonprotein thioether and is a key amino acid associated with the metabolic state of sulfur-containing amino acids. L-Cystathionine protects against Homocysteine-induced mitochondria-dependent apoptosis of vascular endothelial cells (HUVECs). L-Cystathionine plays an important role in cardiovascular protection.

For research use only. We do not sell to patients.

L-Cystathionine Chemical Structure

L-Cystathionine Chemical Structure

CAS No. : 56-88-2

Size Price Stock Quantity
5 mg USD 85 In-stock
Estimated Time of Arrival: December 31
10 mg USD 145 In-stock
Estimated Time of Arrival: December 31
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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of L-Cystathionine:

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Description

L-Cystathionine is a nonprotein thioether and is a key amino acid associated with the metabolic state of sulfur-containing amino acids. L-Cystathionine protects against Homocysteine-induced mitochondria-dependent apoptosis of vascular endothelial cells (HUVECs). L-Cystathionine plays an important role in cardiovascular protection[1][2].

IC50 & Target[1]

Human Endogenous Metabolite

 

In Vitro

Homocysteine obviously induces the apoptosis of HUVECs, and this effect is significantly attenuated by the pretreatment with L-cystathionine. Furthermore, L-cystathionine decreases the production of mitochondrial superoxide anion and the expression of Bax and restrained its translocation to mitochondria, increases mitochondrial membrane potential, inhibits mitochondrial permeability transition pore (MPTP) opening, suppresses the leakage of cytochrome c from mitochondria into the cytoplasm, and downregulated activities of caspase-9 and caspase-3[1].
L-Cystathionine is an important metabolic intermediate in the L-cysteine transsulfuration pathway from L-methionine via L-homocysteine in mammalian tissues[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

222.26

Formula

C₇H₁₄N₂O₄S

CAS No.
SMILES

N[[email protected]@H](CCSC[[email protected]](N)C(O)=O)C(O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Solvent & Solubility
In Vitro: 

H2O : 25 mg/mL (112.48 mM; ultrasonic and warming and adjust pH to 11 with NaOH and heat to 80°C)

DMSO : 1 mg/mL (4.50 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.4992 mL 22.4962 mL 44.9924 mL
5 mM 0.8998 mL 4.4992 mL 8.9985 mL
10 mM 0.4499 mL 2.2496 mL 4.4992 mL
*Please refer to the solubility information to select the appropriate solvent.
References

Purity: ≥99.0%

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Keywords:

L-CystathionineEndogenous MetaboliteApoptosisaminoacidsulfur-containingHomocysteineapoptosisvascularendothelialcellscardiovascularHUVECsInhibitorinhibitorinhibit

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Product Name:
L-Cystathionine
Cat. No.:
HY-W009749
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