L-Cystathionine
Based on 1 publication(s) in Google Scholar
L-Cystathionine is a nonprotein thioether and is a key amino acid associated with the metabolic state of sulfur-containing amino acids. L-Cystathionine protects against Homocysteine-induced mitochondria-dependent apoptosis of vascular endothelial cells (HUVECs). L-Cystathionine plays an important role in cardiovascular protection.
For research use only. We do not sell to patients.
- Purity: 99.0%
- CAS No.: 56-88-2
- Formula: C7H14N2O4S
- Molecular Weight:222.26
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Storage:
-20°C, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) L-Cystathionine
MoreAll Endogenous Metabolite Isoforms
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Biological Activity
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Human Endogenous Metabolite |
Homocysteine obviously induces the apoptosis of HUVECs, and this effect is significantly attenuated by the pretreatment with L-cystathionine. Furthermore, L-cystathionine decreases the production of mitochondrial superoxide anion and the expression of Bax and restrained its translocation to mitochondria, increases mitochondrial membrane potential, inhibits mitochondrial permeability transition pore (MPTP) opening, suppresses the leakage of cytochrome c from mitochondria into the cytoplasm, and downregulated activities of caspase-9 and caspase-3[1].
L-Cystathionine is an important metabolic intermediate in the L-cysteine transsulfuration pathway from L-methionine via L-homocysteine in mammalian tissues[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 56-88-2
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Appearance Solid
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Molecular Weight 222.26
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Formula C7H14N2O4S
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Color White to off-white
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SMILES
N[C@@H](CCSC[C@H](N)C(O)=O)C(O)=O
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Structure Classification
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
Publications (1)
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Journal Impact Factor
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Most Recent
Solvent & Solubility
1M HCl : 50 mg/mL (224.96 mM; ultrasonic and adjust pH to 1 with HCl)
H2O : 40 mg/mL (179.97 mM; adjust pH to 2 with 1 M HCl)
H2O : 25 mg/mL (112.48 mM; ultrasonic and adjust pH to 10 with NaOH)
DMSO : < 1 mg/mL (insoluble or slightly soluble)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
For the following dissolution methods, please prepare the working solution directly:
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: PBS
Solubility: 3.33 mg/mL (14.98 mM); Clear solution; Need ultrasonic
Purity & Documentation
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Data Sheet (272 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
[1]. Xiuli Wang, et al. L-Cystathionine Protects against Homocysteine-Induced Mitochondria-Dependent Apoptosis of Vascular Endothelial Cells. Oxid Med Cell Longev. 2019 Nov 25;2019:1253289. [Content Brief]
[2]. Amino Y, et al. Synthesis and evaluation of L-cystathionine as a standard for amino acid analysis. Biosci Biotechnol Biochem. 2017 Jan;81(1):95-101. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O / H2O / 1M HCl | 1 mM | 4.4992 mL | 22.4962 mL | 44.9924 mL | 112.4809 mL |
| 5 mM | 0.8998 mL | 4.4992 mL | 8.9985 mL | 22.4962 mL | |
| 10 mM | 0.4499 mL | 2.2496 mL | 4.4992 mL | 11.2481 mL | |
| 15 mM | 0.2999 mL | 1.4997 mL | 2.9995 mL | 7.4987 mL | |
| 20 mM | 0.2250 mL | 1.1248 mL | 2.2496 mL | 5.6240 mL | |
| 25 mM | 0.1800 mL | 0.8998 mL | 1.7997 mL | 4.4992 mL | |
| 30 mM | 0.1500 mL | 0.7499 mL | 1.4997 mL | 3.7494 mL | |
| 40 mM | 0.1125 mL | 0.5624 mL | 1.1248 mL | 2.8120 mL | |
| 50 mM | 0.0900 mL | 0.4499 mL | 0.8998 mL | 2.2496 mL | |
| 60 mM | 0.0750 mL | 0.3749 mL | 0.7499 mL | 1.8747 mL | |
| 80 mM | 0.0562 mL | 0.2812 mL | 0.5624 mL | 1.4060 mL | |
| 100 mM | 0.0450 mL | 0.2250 mL | 0.4499 mL | 1.1248 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
L-Cystathionine Related Classifications
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