1. GPCR/G Protein
  2. GPR120
  3. AH-7614

AH-7614 

Cat. No.: HY-19996
Handling Instructions

AH-7614 is a potent and selective FFA4 (GPR120) antagonist, with pIC50s of 7.1, 8.1, and 8.1 for human, mouse, and rat FFA4, respectively. AH-7614 has selectivity for FFA4 over FFA1 (pIC50<4.6). AH-7614 is able to block effects of both the polyunsaturated ω-6 fatty acid linoleic acid and the synthetic FFA4 agonist.

For research use only. We do not sell to patients.

AH-7614 Chemical Structure

AH-7614 Chemical Structure

CAS No. : 6326-06-3

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Description

AH-7614 is a potent and selective FFA4 (GPR120) antagonist, with pIC50s of 7.1, 8.1, and 8.1 for human, mouse, and rat FFA4, respectively. AH-7614 has selectivity for FFA4 over FFA1 (pIC50<4.6). AH-7614 is able to block effects of both the polyunsaturated ω-6 fatty acid linoleic acid and the synthetic FFA4 agonist[1][2].

IC50 & Target

pIC50: 7.1 (human FFA4)[1]

In Vitro

AH-7614 (compound 39) (0.063-1 μM) blocks intracellular Ca2+ response induced by both linoleic acid and FFAR4 agonist in FFA4 expressing U2OS cells[1].
AH-7614 (100 μM) abolishes the enhancement in glucose-stimulated insulin secretion by GSK137647A in NCI-H716 cells[1].
AH-7614 (0.001-10 μM; 15 min) blocks TUG-891-mediated internalization of FFA4 from the cell surface (pIC50=7.70)[2].
AH-7614 (10 μM; 30 min) blocks agonist-induced elevation of intracellular inositol monophosphates and phosphorylation of FFA4[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

AH7614 (50 μg; intratumoral injection once every 4 d for 20 d) reduces the tumor growth in mice[3].
AH7614 (50 μg; intratumoral injection one day prior to epirubicin injection) enhances cancer cell sensitivity to the chemotherapy and inhibit tumor progression by blocking GPR120 signaling in combination with Epirubicin[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

351.42

Formula

C₂₀H₁₇NO₃S

CAS No.

6326-06-3

SMILES

O=S(C1=CC=C(C)C=C1)(NC2C3=C(OC4=C2C=CC=C4)C=CC=C3)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

AH-7614AH7614AH 7614GPR120G-protein coupled receptor 120FFA4negativeallostericNAMlinoleicacidInhibitorinhibitorinhibit

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AH-7614
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HY-19996
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