10(E)-Pentadecenoic acid  (Synonyms: trans-10-Pentadecenoic acid)

10 (E)-Pentadecenoic acid (trans-10-Pentadecenoic acid) is a melanin synthesis inhibitor. 10 (E)-Pentadecenoic acid inhibits nuclear translocation and reduces the protein level of phosphorylated microphthalmia-associated transcription factor (MITF), as well as decreases intracellular tyrosinase activity. 10 (E)-Pentadecenoic acid can be used in the research of skin pigmentation disorders^[1].

10(E)-Pentadecenoic acid (1-60 μM; 10 min) exhibits dose-dependent copper ion reduction capacity, as measured by the CUPRAC assay, with the highest activity at 60 μM^[1].
10(E)-Pentadecenoic acid (1-60 μM; 20 min) only slightly inhibits mushroom tyrosinase activity at 1 μM, with no significant inhibition at higher concentrations (5, 15, 60 μM)^[1].
10(E)-Pentadecenoic acid (1-100 μM; 24 h) is non-cytotoxic to Hs68 human dermal fibroblast cells at concentrations up to 100 μM, but shows cytotoxicity to B16F10 murine melanoma cells at ≥50 μM and to HaCaT human keratinocyte cells at 100 μM^[1].
10(E)-Pentadecenoic acid (1-15 μM; 1 h pre-incubation, followed by 6 days co-incubation with 500 nM α-MSH) dose-dependently reduces α-MSH-stimulated melanin production in B16F10 murine melanoma cells at concentrations of 1, 5, and 15 μM^[1].
10(E)-Pentadecenoic acid (1-15 μM; 1 h pre-incubation, followed by 3 days co-incubation with 500 nM α-MSH) dose-dependently inhibits α-MSH-stimulated intracellular tyrosinase activity in B16F10 murine melanoma cells at concentrations of 1, 5, and 15 μM^[1].
10(E)-Pentadecenoic acid (5-15 μM; 1 h pre-incubation, followed by 6 days co-incubation with 500 nM α-MSH) reduces α-MSH-stimulated mRNA expression of TRP-1, TRP-2, and tyrosinase in B16F10 murine melanoma cells at concentrations of 5 and 15 μM^[1].
10(E)-Pentadecenoic acid (5-15 μM; 1 h pre-incubation, followed by 6 days co-incubation with 500 nM α-MSH) reduces α-MSH-stimulated protein expression of TRP-1, tyrosinase, and p-MITF (but not TRP-2) in B16F10 murine melanoma cells at concentrations of 5 and 15 μM^[1].
10(E)-Pentadecenoic acid (5-15 μM; co-incubation with 500 nM α-MSH) inhibits α-MSH-stimulated nuclear translocation of MITF in B16F10 murine melanoma cells at concentrations of 5 and 15 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

240.38

C₁₅H₂₈O₂

321744-58-5

Liquid

Colorless to light yellow

OC(CCCCCCCC/C=C/CCCC)=O

Room temperature in continental US; may vary elsewhere.

Solution, -20°C, 2 years

• [1]. Lee MK, et al. 10(E)-Pentadecenoic Acid Inhibits Melanogenesis Partly Through Suppressing the Intracellular MITF/Tyrosinase Axis. Antioxidants (Basel). 2024 Dec 17;13(12):1547.