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3-Chloro-5-hydroxybenzoic acid 

Cat. No.: HY-W016868 Purity: ≥98.0%
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3-Chloro-5-hydroxybenzoic acid is a potent, orally active and selective lactate receptor GPR81 agonist, with an EC50 of 16 μM for human GPR81. 3-Chloro-5-hydroxybenzoic acid exhibits favorable in vivo effects on lipolysis in a mouse model of obesity.

For research use only. We do not sell to patients.

3-Chloro-5-hydroxybenzoic acid Chemical Structure

3-Chloro-5-hydroxybenzoic acid Chemical Structure

CAS No. : 53984-36-4

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25 mg USD 50 In-stock
Estimated Time of Arrival: December 31
50 mg USD 70 In-stock
Estimated Time of Arrival: December 31
100 mg USD 90 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

3-Chloro-5-hydroxybenzoic acid is a potent, orally active and selective lactate receptor GPR81 agonist, with an EC50 of 16 μM for human GPR81. 3-Chloro-5-hydroxybenzoic acid exhibits favorable in vivo effects on lipolysis in a mouse model of obesity[1].

In Vitro

3-Chloro-5-hydroxybenzoic acid shows potency against human (EC50=16 μM), monkey (EC50=17 μM), dog (EC50=67 μM), rat (EC50=7 μM), mouse (EC50=22 μM), and hamster GPR81 (EC50=27 μM)[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

3-Chloro-5-hydroxybenzoic acid (30, 100, and 300 mg/kg; PO in overnight fasted C57Bl6/J mice fed high fat chow for 10 weeks) shows significant reductions in free fatty acids at all doses tested, resulting in a minimum efficacious dose of 30 mg/kg[1].
Pharmacokinetic Parameters of 3-Chloro-5-hydroxybenzoic acid in Mice[1].

dose (mg/kg) tmax (h) AUCinf (h ng/mL) Cmax (ng/mL) Cmax (μM) t1/2 (h)
30 0.5 9356 11689.50 67.2 1.47
100 0.5 51312 55252.80 341.9 1.10

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57Bl6/J mice (DIO mice)[1]
Dosage: 30, 100, and 300 mg/kg
Administration: PO in overnight fasted C57Bl6/J mice fed high fat chow for 10 weeks
Result: Significant reductions in nonesterified free fatty acid cholesterol (NEFAc) at all doses tested.
Molecular Weight

172.57

Formula

C7H5ClO3

CAS No.
SMILES

ClC1=CC(O)=CC(C(O)=O)=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (579.47 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 5.7947 mL 28.9737 mL 57.9475 mL
5 mM 1.1589 mL 5.7947 mL 11.5895 mL
10 mM 0.5795 mL 2.8974 mL 5.7947 mL
*Please refer to the solubility information to select the appropriate solvent.
Purity & Documentation

Purity: 98.01%

References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
3-Chloro-5-hydroxybenzoic acid
Cat. No.:
HY-W016868
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