3-Chloro-5-hydroxybenzoic acid
Based on 5 publication(s) in Google Scholar
3-Chloro-5-hydroxybenzoic acid is a potent, orally active and selective lactate receptor GPR81 agonist, with an EC50 of 16 μM for human GPR81. 3-Chloro-5-hydroxybenzoic acid exhibits favorable in vivo effects on lipolysis in a mouse model of obesity.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度 : 99.54%
- CAS 番号: 53984-36-4
- 分子式: C7H5ClO3
- 分子量:172.57
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保管条件:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- プロトコル
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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HY-135982
GPR81 agonist 1GPR81 Agonist -
HY-W015560
3,5-Dihydroxybenzoic acidGPR81 Agonist -
HY-W004049
3-Hydroxybenzoic acidendogenous metabolite -
HY-W010452
3-Hydroxybutyric acid sodium -
HY-16214
FX-11LDHA Inhibitor -
HY-B2227B
Lactic acid sodium (60% w/w in water)Glycolysis Production -
HY-116522
AR420626FFAR3 Agonist -
HY-13248
AR-C155858MCT1/2 Inhibitor -
HY-W004049R
3-Hydroxybenzoic acid (Standard)endogenous metabolite -
HY-W015560R
3,5-Dihydroxybenzoic acid (Standard)GPR81 Agonist -
HY-12764
6-OAUGPR84 Agonist -
HY-12764R
6-OAU (Standard)GPR84 Agonist
MedChemExpress（MCE）の使用を引用している文献 3-Chloro-5-hydroxybenzoic acid
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生物活性
製品説明
IC50 & Target
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GPR81 |
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| COS-7 | EC50 |
16 μM
Compound: 2
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Agonist activity at human recombinant GPR81 transfected in african green monkey COS-7 cells after 20 mins by [35S]GTPgammaS binding assay
Agonist activity at human recombinant GPR81 transfected in african green monkey COS-7 cells after 20 mins by [35S]GTPgammaS binding assay
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[PMID: 24900524] |
| COS-7 | EC50 |
>1000 μM
Compound: 2
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Agonist activity at human recombinant GPR109a transfected in african green monkey COS-7 cells after 20 mins by [35S]GTPgammaS binding assay
Agonist activity at human recombinant GPR109a transfected in african green monkey COS-7 cells after 20 mins by [35S]GTPgammaS binding assay
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[PMID: 24900524] |
体外実験
3-Chloro-5-hydroxybenzoic acid shows potency against human (EC50=16 μM), monkey (EC50=17 μM), dog (EC50=67 μM), rat (EC50=7 μM), mouse (EC50=22 μM), and hamster GPR81 (EC50=27 μM)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
体内実験
Pharmacokinetic Parameters of 3-Chloro-5-hydroxybenzoic acid in Mice[1].
| dose (mg/kg) | tmax (h) | AUCinf (h ng/mL) | Cmax (ng/mL) | Cmax (μM) | t1/2 (h) |
| 30 | 0.5 | 9356 | 11689.50 | 67.2 | 1.47 |
| 100 | 0.5 | 51312 | 55252.80 | 341.9 | 1.10 |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:C57Bl6/J mice (DIO mice)[1]
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Dosage:30, 100, and 300 mg/kg
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Administration:PO in overnight fasted C57Bl6/J mice fed high fat chow for 10 weeks
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Result:Significant reductions in nonesterified free fatty acid cholesterol (NEFAc) at all doses tested.
化学情報
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CAS 番号 53984-36-4
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性状 Solid
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分子量 172.57
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分子式 C7H5ClO3
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Color White to light brown
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SMILES
ClC1=CC(O)=CC(C(O)=O)=C1
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (5)
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Journal Impact Factor
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Most Recent
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PLoS Biol
Structures of G-protein coupled receptor HCAR1 in complex with Gi1 protein reveal the mechanistic basis for ligand recognition and agonist selectivity. [Abstract]2025 Apr 15;23(4):e3003126. PMID: 40233099 -
Inflamm Res
Lactate acts as a metabolic brake on inflammation by repressing NLRP3 transcription via NF-κB inhibition. [Abstract]2026 Jun 11;75(1):137. PMID: 42274732 -
J Pathol
Lactate-mediated activation of GPR81 regulates BCR/Abl protein expression in chronic myeloid leukemia cells selected under low oxygen tension. [Abstract]2025 Oct 23. PMID: 41128634 -
Food Sci Nutr
Octanoic Acid-Rich Enteral Nutrition Alleviates Sepsis-Associated Metabolic Disorders by Suppressing White Adipose Tissue Browning in Mice. [Abstract]2026 Jun 9;14(6):e72020. PMID: 42282442
溶剤 & 溶解度
体外:
DMSO : 100 mg/mL (579.47 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Working solution concentration: 0.22 mg/mL
純度とドキュメンテーション
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データシート (275 KB)
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SDS (615 KB)
- English - EN (615 KB)
- Français - FR (615 KB)
- Deutsch - DE (615 KB)
- Norwegian - NO (615 KB)
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- Italian - IT (615 KB)
- Korean - KR (615 KB)
- Portuguese - PT (615 KB)
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取扱説明書 (2659 KB)
参考文献
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 5.7947 mL | 28.9737 mL | 57.9475 mL | 144.8687 mL |
| 5 mM | 1.1589 mL | 5.7947 mL | 11.5895 mL | 28.9737 mL | |
| 10 mM | 0.5795 mL | 2.8974 mL | 5.7947 mL | 14.4869 mL | |
| 15 mM | 0.3863 mL | 1.9316 mL | 3.8632 mL | 9.6579 mL | |
| 20 mM | 0.2897 mL | 1.4487 mL | 2.8974 mL | 7.2434 mL | |
| 25 mM | 0.2318 mL | 1.1589 mL | 2.3179 mL | 5.7947 mL | |
| 30 mM | 0.1932 mL | 0.9658 mL | 1.9316 mL | 4.8290 mL | |
| 40 mM | 0.1449 mL | 0.7243 mL | 1.4487 mL | 3.6217 mL | |
| 50 mM | 0.1159 mL | 0.5795 mL | 1.1589 mL | 2.8974 mL | |
| 60 mM | 0.0966 mL | 0.4829 mL | 0.9658 mL | 2.4145 mL | |
| 80 mM | 0.0724 mL | 0.3622 mL | 0.7243 mL | 1.8109 mL | |
| 100 mM | 0.0579 mL | 0.2897 mL | 0.5795 mL | 1.4487 mL |
3-Chloro-5-hydroxybenzoic acid 関連分類
HY-W016868 関連分類
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