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Art. -Nr.: HY-W454906

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tDHU, acid

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tDHU, acid is a type of dihydropyrimidine Cereblon ligand and a benzoic acid linker conjugate, which can be used in the development of PROTACs.

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Reinheit: 98.83%
CAS. Nr.: 2377643-37-1
Formel: C₁₂H₁₂N₂O₄
Molecular Weight:248.23

Speicherung:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month

tDHU, acid Chemical Structure

CAS. Nr.: 2377643-37-1

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- Cellular Effect
- In Vitro
Chemical Information
Lösungsmittel & Löslichkeit
- In Vitro
Reinheit & Dokumentation
Verweise
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

tDHU, acid is a type of dihydropyrimidine Cereblon ligand and a benzoic acid linker conjugate, which can be used in the development of PROTACs^[1].

IC₅₀ & Target

Cereblon

Alle E3 Ligase Ligand-Linker Conjugates Isoform-spezifische Produkte anzeigen :

Cellular Effect

Cell Line	Type	Value	Description	References
HEK293	EC₅₀	>50 μM Compound: tDHU-CO2H	Cytotoxicity against human HEK293 cells assessed as inhibition of cell viability incubated for 30 mins by cell titer-glo assay Cytotoxicity against human HEK293 cells assessed as inhibition of cell viability incubated for 30 mins by cell titer-glo assay	[PMID: 35859867]
HEK293	IC₅₀	>50 μM Compound: tDHU-CO2H	Cytotoxicity against human HEK293 cells assessed as inhibition of cell viability incubated for 30 mins in presence of CRBN-tracer by nanoBRET assay Cytotoxicity against human HEK293 cells assessed as inhibition of cell viability incubated for 30 mins in presence of CRBN-tracer by nanoBRET assay	[PMID: 35859867]
HEK293	IC₅₀	1.94 μM Compound: tDHU-CO2H	Cytotoxicity against permeabilized HEK293 cells assessed as inhibition of cell viability incubated for 30 mins in presence of CRBN-tracer by nanoBRET assay Cytotoxicity against permeabilized HEK293 cells assessed as inhibition of cell viability incubated for 30 mins in presence of CRBN-tracer by nanoBRET assay	[PMID: 35859867]

In Vitro

tDHU, acid is a click chemistry reagent. tDHU, acid contains an Azide group, which can undergo a copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. tDHU, acid can also undergo a ring tension-driven acetylene-azide cycloaddition reaction (SPAAC) with molecules containing DBCO or BCN groups.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS. Nr. 2377643-37-1
Appearance Solid
Molecular Weight 248.23
Formel C₁₂H₁₂N₂O₄
Color White to off-white
SMILES

O=C(C1=CC=C(C)C(N2C(NC(CC2)=O)=O)=C1)O
Versand

Room temperature in continental US; may vary elsewhere.

Speicherung

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Lösungsmittel & Löslichkeit

In Vitro:

DMSO : 17.5 mg/mL (70.50 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

4.0285 mL

20.1426 mL

40.2852 mL

5 mM

0.8057 mL

4.0285 mL

8.0570 mL

10 mM

0.4029 mL

2.0143 mL

4.0285 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (272 KB)
SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Novartis AG, et al. Preparation of dihydropyrimidine derivatives as bifunctional degraders for the treatment and prophylaxis of target protein-mediated diseases. World Intellectual Property Organization, WO2021053495 A1 2021-03-25.

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	4.0285 mL	20.1426 mL	40.2852 mL	100.7131 mL
	5 mM	0.8057 mL	4.0285 mL	8.0570 mL	20.1426 mL
	10 mM	0.4029 mL	2.0143 mL	4.0285 mL	10.0713 mL
	15 mM	0.2686 mL	1.3428 mL	2.6857 mL	6.7142 mL
	20 mM	0.2014 mL	1.0071 mL	2.0143 mL	5.0357 mL
	25 mM	0.1611 mL	0.8057 mL	1.6114 mL	4.0285 mL
	30 mM	0.1343 mL	0.6714 mL	1.3428 mL	3.3571 mL
	40 mM	0.1007 mL	0.5036 mL	1.0071 mL	2.5178 mL
	50 mM	0.0806 mL	0.4029 mL	0.8057 mL	2.0143 mL
	60 mM	0.0671 mL	0.3357 mL	0.6714 mL	1.6786 mL

Keywords

100 mg

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Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
Chemical Information
Lösungsmittel & Löslichkeit
- In Vitro
Reinheit & Dokumentation
Verweise

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tDHU, acid

Alle E3 Ligase Ligand-Linker Conjugates Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

tDHU, acid Related Classifications

HY-W454906 Related Classifications