1. Signaling Pathways
  2. PROTAC
  3. E3 Ligase Ligand-Linker Conjugates
  4. E3 Ligase Ligand-Linker Conjugates Inhibitors

E3 Ligase Ligand-Linker Conjugates Inhibitors

von Hippel-Lindau (VHL)

MDM2

Cereblon

cIAP1

Aryl Hydrocarbon Receptor

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E3 Ligase Ligand-Linker Conjugates
Product Name von Hippel-Lindau (VHL) MDM2 Cereblon cIAP1 Aryl Hydrocarbon Receptor Purity
Thalidomide    
Cereblon
    99.92%
Thalidomide 4-fluoride    
Cereblon
    99.92%
Thalidomide 5-fluoride    
Cereblon
    99.9%
(S,R,S)-AHPC-PEG5-COOH
VHL
        99.88%
Thalidomide-5-OH    
Cereblon
    99.65%
Thalidomide-4-OH    
Cereblon
    99.85%
(S,R,S)-AHPC-PEG4-N3
VHL
        99.73%
(S,R,S)-AHPC-PEG3-N3
VHL
        99.67%
Thalidomide-O-PEG4-NHS ester    
Cereblon
    98.23%
Thalidomide-O-COOH    
Cereblon
    99.85%
Lenalidomide-C5-NH2 hydrochloride    
Cereblon
    98.44%
(S,R,S)-AHPC-PEG1-N3
VHL
        98.18%
Pomalidomide-PEG1-C2-N3    
Cereblon
    99.91%
(S,R,S)-AHPC-PEG2-N3
VHL
        99.74%
N-Descyclopropanecarbaldehyde Olaparib    
Cereblon
    99.27%
(S,R,S)-AHPC-PEG3-NH2 hydrochloride
VHL
        98.20%
Thalidomide-NH-CH2-COOH    
Cereblon
    98.20%
Pomalidomide 4'-alkylC5-acid    
Cereblon
    98.78%
(S,R,S)-AHPC-amido-C5-acid
VHL
        99.58%
(S,R,S)-AHPC-PEG4-NH2
VHL
        99.51%
Pomalidomide 4'-PEG5-acid    
Cereblon
   
VH032-PEG3-acetylene
VHL
        98.14%
Pomalidomide-PEG4-azide    
Cereblon
    99.85%
(S,R,S)-AHPC-PEG2-NH2 hydrochloride
VHL
       
Pomalidomide-C2-NH2 hydrochloride    
Cereblon
    99.46%
Thalidomide-O-PEG2-propargyl    
Cereblon
    98.26%
Pomalidomide-PEG1-C2-COOH    
Cereblon
    99.88%
Pomalidomide-PEG4-C-COOH    
Cereblon
    99.10%
Thalidomide-O-amido-C3-COOH    
Cereblon
    98.43%
Pomalidomide-C7-COOH    
Cereblon
    98.07%
Thalidomide-O-C8-COOH    
Cereblon
   
Thalidomide-4-O-C6-NH2 hydrochloride    
Cereblon
    98.53%
Thalidomide-NH-PEG3-propionic acid    
Cereblon
    99.72%
Pomalidomide-PEG3-azide    
Cereblon
    98.88%
Pomalidomide-amido-C3-COOH    
Cereblon
    98.22%
Biotin-PEG6-Thalidomide    
Cereblon
    98.51%
Thalidomide-Piperazine-PEG1-COOH    
Cereblon
    99.79%
Nutlin-C1-amido-PEG4-C2-N3  
MDM2
      99.19%
Thalidomide-5-COOH    
Cereblon
    99.97%
Pomalidomide-amino-PEG3-NH2 hydrochloride    
Cereblon
    99.52%
Thalidomide-O-amido-PEG4-azide    
Cereblon
    99.64%
Lenalidomide-propargyl-C2-NH2 hydrochloride    
Cereblon
    98.04%
(S,R,S)-AHPC-C8-NH2
VHL
       
Thalidomide-PEG3-COOH    
Cereblon
    98.05%
Pomalidomide-PEG2-azide    
Cereblon
   
Thalidomide-O-C5-acid    
Cereblon
   
Thalidomide-propargyl    
Cereblon
    99.97%
Pomalidomide-amino-PEG5-NH2 hydrochloride    
Cereblon
    99.58%
Thalidomide-5,6-F    
Cereblon
    99.84%
Thalidomide-PEG2-C2-NH2 TFA    
Cereblon
    99.39%
Pomalidomide-PEG3-C2-NH2 TFA    
Cereblon
    99.0%
Pomalidomide 4'-PEG3-azide    
Cereblon
   
(S,R,S)-AHPC-C2-NH2 dihydrochloride
VHL
        98.85%
Pomalidomide-PEG4-C2-NH2 hydrochloride    
Cereblon
    99.11%
Thalidomide-Piperazine-PEG3-COOH    
Cereblon
    99.66%
Thalidomide-NH-C5-NH2 hydrochloride    
Cereblon
    99.28%
(S,R,S)-AHPC-Me-C5-COOH
VHL
       
Thalidomide-O-C2-acid    
Cereblon
   
Thalidomide-O-C6-COOH    
Cereblon
    99.67%
(S,R,S)-AHPC-PEG4-NH2 hydrochloride
VHL
        98.06%
Thalidomide-PEG2-NH2 hydrochloride    
Cereblon
   
(S,R,S)-AHPC-C3-NH2 hydrochloride
VHL
       
(S,R,S)-AHPC-(C3-​PEG)​2-​C6-​Cl
VHL
        98.85%
A 410099.1, amine-Boc hydrochloride      
cIAP1
 
Thalidomide-O-amido-C4-N3    
Cereblon
    98.36%
Thalidomide-PEG2-C2-NH2 hydrochloride    
Cereblon
    99.61%
Thalidomide-NH-PEG2-C2-NH-Boc    
Cereblon
    98.37%
Lenalidomide-acetylene-C5-COOH    
Cereblon
    98.32%
Thalidomide-O-C8-Boc    
Cereblon
   
Thalidomide-NH-PEG3-COOH    
Cereblon
    98.33%
(S,R,S)-AHPC-C4-NH2 dihydrochloride
VHL
       
Thalidomide-O-amido-C4-NH2 hydrochloride    
Cereblon
    98.11%
Thalidomide-PEG5-COOH    
Cereblon
    98.09%
Thalidomide-O-amido-PEG3-C2-NH2 hydrochloride    
Cereblon
    98.29%
(S,R,S)-AHPC-Me-CO-CH2-PEG3-NH2
VHL
       
Thalidomide-NH-PEG2-COOH    
Cereblon
    98.74%
Thalidomide-Piperazine-PEG2-COOH    
Cereblon
    98.96%
(S,R,S)-AHPC-C6-NH2
VHL
        98.03%
Pomalidomide-C2-amido-(C1-O-C5-O-C1)2-COOH    
Cereblon
   
Thalidomide-PEG5-NH2 hydrochloride    
Cereblon
   
Lenalidomide-C4-NH2 hydrochloride    
Cereblon
    98.85%
Thalidomide-O-amido-PEG3-C2-NH2 TFA    
Cereblon
    99.55%
Pomalidomide-C12-NH2 hydrochloride    
Cereblon
   
Thalidomide-O-amido-C3-NH2 TFA    
Cereblon
    98.18%
Thalidomide-O-amido-C6-NH2 TFA    
Cereblon
    99.82%
(S,R,S)-AHPC-PEG5-Boc
VHL
       
Thalidomide-NH-C6-NH-Boc    
Cereblon
   
Thalidomide-O-amido-PEG2-C2-NH2 TFA    
Cereblon
    99.52%
Thalidomide-O-amido-C4-NH2    
Cereblon
   
Lenalidomide-propargyl-C2-amido-Ph-NH2 hydrochloride    
Cereblon
   
Thalidomide-4-O-C4-NH2 hydrochloride    
Cereblon
    99.15%
Thalidomide-Piperazine-PEG1-NH2    
Cereblon
   
Thalidomide-NH-C6-NH2 TFA    
Cereblon
    99.82%
Thalidomide-PEG4-NH2 hydrochloride    
Cereblon
   
Thalidomide-O-amido-C3-PEG3-C1-NH2    
Cereblon
    99.48%
Thalidomide-O-amido-PEG3-C2-NH2    
Cereblon
   
Pomalidomide-PEG6-NH2 hydrochloride    
Cereblon
    98.01%
Thalidomide-Piperazine-PEG2-NH2    
Cereblon
   
Thalidomide-O-amido-PEG1-(C1-PEG)2-C2-NH2 TFA    
Cereblon
    99.28%
(S,R,S)-AHPC-Me-C10-Br
VHL
       
Pomalidomide-amido-C1-Br    
Cereblon
   
(S,R,S)-AHPC-PEG3-propionic acid
VHL
       
Thalidomide-O-amido-PEG4-C2-NH2 hydrochloride    
Cereblon
   
Thalidomide-Propargyne-PEG1-COOH    
Cereblon
    99.45%
Thalidomide-Propargyne-PEG3-COOH    
Cereblon
    98.01%
(S,R,S)-AHPC-PEG3-NH2
VHL
        99.26%
(S,R,S)-AHPC-C6-NH2 hydrochloride
VHL
       
Pomalidomide-PEG6-butyl iodide    
Cereblon
    98.35%
(S,R,S)-AHPC-PEG2-NH2
VHL
       
Pomalidomide-PEG4-C2-NH2    
Cereblon
   
(S,R,S)-AHPC-O-Ph-PEG1-NH2
VHL
       
Thalidomide-piperazine-Boc    
Cereblon
    99.75%
Thalidomide-Propargyne-PEG2-COOH    
Cereblon
    99.07%
Thalidomide-PEG4-COOH    
Cereblon
   
Thalidomide-NH-PEG4-COOH    
Cereblon
    98.55%
Pomalidomide-amido-PEG3-C2-NH2    
Cereblon
    99.55%
(S,R,S)-AHPC-PEG2-NH2 dihydrochloride
VHL
       
Thalidomide-4-O-C2-NH2 hydrochloride    
Cereblon
    99.37%
Thalidomide-O-amido-PEG-C2-NH2 hydrochloride    
Cereblon
    98.54%
(S,R,S)-AHPC-C8-NH2 hydrochloride
VHL
       
Glutarimide-Isoindolinone-NH-PEG2-COOH    
Cereblon
    98.51%
Thalidomide-4-O-C8-NH2 hydrochloride    
Cereblon
   
Thalidomide-NH-C10-COOH    
Cereblon
   
Thalidomide-Piperazine-Piperidine hydrochloride    
Cereblon
    98.73%
Pomalidomide-PEG3-C2-NH2    
Cereblon
   
Pomalidomide-PEG3-C2-NH2 hydrochloride    
Cereblon
   
Thalidomide-O-PEG4-azide    
Cereblon
    98.03%
(S,R,S)-AHPC-C1-Br
VHL
        ≥98.0%
Thalidomide-4-O-C5-NH2 hydrochloride    
Cereblon
   
Thalidomide-Piperazine-PEG1-NH2 diTFA    
Cereblon
    99.84%
(S,R,S)-AHPC-C4-NH2 hydrochloride
VHL
       
Thalidomide-5-methyl    
Cereblon
   
Thalidomide-O-amido-C8-NH2 TFA    
Cereblon
    99.43%
Pomalidomide-amino-PEG4-NH2    
Cereblon
   
Thalidomide-NH-PEG1-NH2 hydrochloride    
Cereblon
    99.59%
Pomalidomide-C4-NH2 hydrochloride    
Cereblon
    99.24%
Thalidomide-4-O-C10-COOH    
Cereblon
    98.86%
Thalidomide-O-PEG4-amine    
Cereblon
   
Thalidomide-NH-C8-NH2 hydrochloride    
Cereblon
   
Pomalidomide-PEG4-Ph-NH2    
Cereblon
    ≥98.0%
Thalidomide-O-PEG4-amine hydrochloride    
Cereblon
   
Lenalidomide-C5-amido-Boc    
Cereblon
   
Thalidomide-5-PEG3-NH2 hydrochloride    
Cereblon
   
Thalidomide-4-O-C3-NH2 hydrochloride    
Cereblon
   
Thalidomide-NH-C6-NH2 hydrochloride    
Cereblon
    99.62%
Glutarimide-Isoindolinone-NH-PEG4-COOH    
Cereblon
    99.52%
Thalidomide-5-PEG4-NH2 hydrochloride    
Cereblon
   
Glutarimide-Isoindolinone-NH-PEG3-COOH    
Cereblon
    99.12%
Thalidomide-Piperazine 5-fluoride    
Cereblon
   
Thalidomide-PEG4-Propargyl    
Cereblon
   
Pomalidomide-C3-NH2 hydrochloride    
Cereblon
   
Pomalidomide-amino-PEG4-NH2 hydrochloride    
Cereblon
    99.27%
Thalidomide-O-amido-C4-NH2 TFA    
Cereblon
    99.74%
Thalidomide-Piperazine-PEG2-NH2 diTFA    
Cereblon
    99.76%
(S,R,S)-AHPC-C10-NH2
VHL
       
Thalidomide-PEG5-NH2    
Cereblon
   
Thalidomide-5-PEG3-NH2    
Cereblon
   
Lenalidomide-PEG3-iodine    
Cereblon
   
Thalidomide-PEG3-NH2    
Cereblon
   
Thalidomide-O-amido-PEG1-(C1-PEG)2-C2-NH2    
Cereblon
   
Thalidomide-4-O-C7-NH2    
Cereblon
   
Thalidomide-NH-C4-NH2 TFA    
Cereblon
   
Thalidomide-O-amido-C3-NH2    
Cereblon
   
Thalidomide 4'-oxyacetamide-alkyl-C2-amine hydrochloride    
Cereblon
   
cIAP1 Ligand-Linker Conjugates 1      
cIAP1
 
Thalidomide-NH-PEG7    
Cereblon
   
Thalidomide-O-amido-C8-NH2 hydrochloride    
Cereblon
   
Thalidomide-Piperazine-PEG3-NH2    
Cereblon
   
Thalidomide-PEG2-C2-NH2    
Cereblon
   
(S,R,S)-AHPC-C3-NH2 TFA
VHL
       
Thalidomide-O-amido-PEG-C2-NH2    
Cereblon
   
Thalidomide-O-amido-PEG2-C2-NH2 hydrochloride    
Cereblon
   
Thalidomide-O-C7-acid    
Cereblon
   
Thalidomide-4-O-C6-NH2 TFA    
Cereblon
   
Thalidomide-O-amide-C5-NH2 TFA    
Cereblon
   
Thalidomide-4-O-C10-NH2    
Cereblon
   
Thalidomide-NH-PEG4-MS    
Cereblon
   
Thalidomide-4-O-C6-NH2    
Cereblon
   
Thalidomide-PEG2-NH2    
Cereblon
   
Thalidomide-O-amido-C6-NH2    
Cereblon
   
Thalidomide-5-PEG4-NH2    
Cereblon
   
Thalidomide-4-O-C8-NH2    
Cereblon
   
Thalidomide-O-C3-acid    
Cereblon
   
Thalidomide-NH-C6-NH2    
Cereblon
   
Thalidomide-Piperazine-Piperidine    
Cereblon
   
Thalidomide-O-amido-PEG2-C2-NH2    
Cereblon
   
Thalidomide-O-amide-C5-NH2    
Cereblon
   
Lenalidomide-C5-NH2 TFA    
Cereblon
    98.94%
Thalidomide-NH-C2-PEG3-OH    
Cereblon
   
(S,R,S)-AHPC-C10-NH2 dihydrochloride
VHL
       
(S,R,S)-AHPC-C6-NH2 dihydrochloride
VHL
       
(S,R,S)-AHPC-PEG1-NH2 dihydrochloride
VHL
       
(S,R,S)-AHPC-C5-COOH
VHL
        98.81%
(S,R,S)-AHPC-C8-NH2 dihydrochloride
VHL
       
Thalidomide-O-amido-PEG4-C2-NH2    
Cereblon
   
Pomalidomide-PEG2-Tos    
Cereblon
   
(S,R,S)-AHPC-C3-NH2
VHL
       
(S,R,S)-AHPC-PEG1-OTs
VHL
       
(S,R,S)-AHPC-C4-NH2
VHL
       
Thalidomide-NH-C4-NH-Boc    
Cereblon
    99.64%
Pomalidomide-amido-C3-piperazine-N-Boc    
Cereblon
   
VHL Ligand-Linker Conjugates 15
VHL
       
(S,R,S)-AHPC-Me-C10-NH2
VHL
       
Pomalidomide-amido-C4-amido-C6-NH-Boc    
Cereblon
   
Pomalidomide-amido-C4-amido-PEG2-C2-NH-Boc    
Cereblon
   
Pomalidomide-amino-PEG5-NH2    
Cereblon
   
cIAP1 Ligand-Linker Conjugates 13      
cIAP1
 
cIAP1 Ligand-Linker Conjugates 15 hydrochloride      
cIAP1
 
(S,R,S)-AHPC-C7-amine
VHL
       
Thalidomide-O-amido-PEG4-propargyl    
Cereblon
   
Thalidomide-4-O-C2-NH2    
Cereblon
   
Thalidomide-NH-amido-PEG3-C2-NH2 hydrochloride    
Cereblon
   
Thalidomide-5-propargyne-NH2 hydrochloride    
Cereblon
   
Pomalidomide-C3-NHS ester    
Cereblon
   
Thalidomide-5-CH2-NH2 hydrochloride    
Cereblon
   
cIAP1 Ligand-Linker Conjugates 14      
cIAP1
 
Thalidomide-O-C3-NH2    
Cereblon
   
A 410099.1 amide-PEG3-amine-Boc      
cIAP1
 
VHL Ligand-Linker Conjugates 17
VHL
       
Pomalidomide-C3-NH2    
Cereblon
   
Thalidomide-amido-PEG2-NH2 hydrochloride    
Cereblon
   
Thalidomide-NH-amido-PEG3-C2-NH2    
Cereblon
   
Thalidomide-NH-amido-C8-NH2    
Cereblon
   
Thalidomide-NH-PEG8-Ts    
Cereblon
   
Thalidomide-O-PEG4-amine TFA    
Cereblon
   
Thalidomide-NH-amido-PEG1-C2-NH2 hydrochloride    
Cereblon
   
Thalidomide-NH-C5-NH2    
Cereblon
   
AhR Ligand-Linker Conjugates 1        
Aryl Hydrocarbon Receptor
Pom-8PEG    
Cereblon
   
Amino-PEG6-Thalidomide    
Cereblon
   
cIAP1 Ligand-Linker Conjugates 2 Hydrochloride      
cIAP1
 
Thalidomide-NH-PEG3-NH-Boc    
Cereblon
   
(S,R,S)-AHPC-C5-NH2
VHL
       
N-Boc-SBP-0636457-O-C3-COOH      
cIAP1
 
Thalidomide-C2-amido-C2-COOH    
Cereblon
   
Thalidomide-NH-amido-C2-NH2 hydrochloride    
Cereblon
   
Pomalidomide-amino-PEG3-NH2    
Cereblon
   
cIAP1 Ligand-Linker Conjugates 3      
cIAP1
 
Lenalidomide-C5-acid    
Cereblon
   
Thalidomide-O-C4-NH2    
Cereblon
   
(S,R,S)-AHPC-Boc-trans-3-aminocyclobutanol-Pip-CH2COOH
VHL
        99.31%
Thalidomide-Piperazine 5-fluoride hydrochloride    
Cereblon
   
Thalidomide-NH-amido-PEG2-C2-NH2 hydrochloride    
Cereblon
   
cIAP1 Ligand-Linker Conjugates 10      
cIAP1
 
VH032-thiol-C6-NH2
VHL
       
Thalidomide-NH-amido-C4-NH2 hydrochloride    
Cereblon
   
Pomalidomide-C6-NHS ester    
Cereblon
   
(S,R,S)-AHPC-PEG1-NH2
VHL
       
Thalidomide-4-O-C5-NH2    
Cereblon
   
Thalidomide-benzo    
Cereblon
   
Thalidomide-O-amido-CH2-PEG3-CH2-NH-Boc    
Cereblon
   
A 410099.1 amide-PEG2-amine-Boc      
cIAP1
 
Thalidomide-NH-amido-C4-NH2    
Cereblon
   
Thalidomide-NH-amido-C3-NH2 hydrochloride    
Cereblon
   
Thalidomide-O-amido-C6-NH2 hydrochloride    
Cereblon
    99.32%
Thalidomide-NH-amido-C3-NH2    
Cereblon
   
cIAP1 Ligand-Linker Conjugates 11 Hydrochloride      
cIAP1
 
Thalidomide-O-C4-COOH    
Cereblon
   
Thalidomide-amido-PEG2-NH2    
Cereblon
   
Thalidomide-4-O-CH2-COO(t-Bu)    
Cereblon
   
Thalidomide-NH-amido-C5-NH2    
Cereblon
   
cIAP1 Ligand-Linker Conjugates 15      
cIAP1
 
cIAP1 Ligand-Linker Conjugates 9      
cIAP1
 
A 410099.1, amine-Boc      
cIAP1
 
cIAP1 Ligand-Linker Conjugates 11      
cIAP1
 
(S,R,S)-AHPC-C2-NH2
VHL
       
Thalidomide-NH-amido-C6-NH2    
Cereblon
   
(S,R,S)-AHPC-C1-NH2 hydrochloride
VHL
        98.08%
Thalidomide-4-C3-NH2 hydrochloride    
Cereblon
   
cIAP1 Ligand-Linker Conjugates 12      
cIAP1
 
Thalidomide-NH-amido-PEG1-C2-NH2    
Cereblon
   
(S,R,S)-AHPC-C1-NH2
VHL
       
Boc-A 410099.1 amide-alkylC4-amine      
cIAP1
 
Thalidomide-NH-C8-NH2    
Cereblon
   
Thalidomide-NH-amido-C8-NH2 hydrochloride    
Cereblon
   
Thalidomide-NH-amido-PEG2-C2-NH2    
Cereblon
   
Thalidomide-NH-PEG1-NH2    
Cereblon
   
Thalidomide-O-C11-acid    
Cereblon
   
Thalidomide-NH-amido-PEG4-C2-NH2 hydrochloride    
Cereblon
   
Thalidomide-O-PEG4-Boc    
Cereblon
   
cIAP1 Ligand-Linker Conjugates 8      
cIAP1
 
Thalidomide-NH-amido-C5-NH2 hydrochloride    
Cereblon
   
cIAP1 Ligand-Linker Conjugates 7      
cIAP1
 
Thalidomide-NH-amido-PEG4-C2-NH2    
Cereblon
   
Thalidomide-O-C6-NHBoc    
Cereblon
   
cIAP1 Ligand-Linker Conjugates 5      
cIAP1
 
Thalidomide-NH-amido-C2-NH2    
Cereblon
   
(S,R,S)-AHPC-C2-PEG4-N3
VHL
       
Thalidomide-5,6-Cl    
Cereblon
   
cIAP1 Ligand-Linker Conjugates 4      
cIAP1
 
Thalidomide-5-propoxyethanamine    
Cereblon
   
cIAP1 Ligand-Linker Conjugates 2      
cIAP1
 
Pomalidomide-C4-NH2    
Cereblon
   
Thalidomide-5-PEG2-Cl    
Cereblon
   
Thalidomide-NH-amido-C6-NH2 hydrochloride    
Cereblon
   
cIAP1 Ligand-Linker Conjugates 6 hydrochloride      
cIAP1
 
Pomalidomide 4'-PEG6-azide    
Cereblon
   
Thalidomide-N-C3-O-C4-O-C3-OH    
Cereblon
   
Pomalidomide-C2-acid    
Cereblon
   
Thalidomide 4'-oxyacetamide-C1-PEG3-C3-amine hydrochloride    
Cereblon
   
Thalidomide-O-amido-C8-NH2    
Cereblon