1. PROTAC
  2. E3 Ligase Ligand-Linker Conjugate
  3. Lenalidomide-propargyl-C2-NH2 hydrochloride

Lenalidomide-propargyl-C2-NH2 hydrochloride 

Cat. No.: HY-130683 Purity: 99.08%
Handling Instructions

Lenalidomide-propargyl-C2-NH2 hydrochloride incorporates a cereblon (CRBN) ligand for the E3 ubiquitin ligase, and a linker. Lenalidomide-propargyl-C2-NH2 hydrochloride can be used to design the PROTAC MD-224 (HY-114312).

For research use only. We do not sell to patients.

Lenalidomide-propargyl-C2-NH2 hydrochloride Chemical Structure

Lenalidomide-propargyl-C2-NH2 hydrochloride Chemical Structure

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5 mg USD 350 In-stock
Estimated Time of Arrival: December 31
10 mg USD 550 In-stock
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25 mg USD 990 In-stock
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50 mg USD 1650 In-stock
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100 mg USD 2250 In-stock
Estimated Time of Arrival: December 31
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Description

Lenalidomide-propargyl-C2-NH2 hydrochloride incorporates a cereblon (CRBN) ligand for the E3 ubiquitin ligase, and a linker. Lenalidomide-propargyl-C2-NH2 hydrochloride can be used to design the PROTAC MD-224 (HY-114312)[1].

IC50 & Target[1] [1] [1]

Cereblon

 

Molecular Weight

361.82

Formula

C₁₈H₂₀ClN₃O₃

SMILES

O=C(C(N(CC1=C2C=CC=C1C#CCCCN)C2=O)CC3)NC3=O.Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
References
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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

Lenalidomide-propargyl-C2-NH2E3 Ligase Ligand-Linker ConjugateCRBNPROTACE3ubiquitinligaselinkerInhibitorinhibitorinhibit

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Product Name:
Lenalidomide-propargyl-C2-NH2 hydrochloride
Cat. No.:
HY-130683
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