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Cat. No.: HY-W591717

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EM-12-alkyne-C3-NH2

1 Cited Publications

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Based on 1 publication(s) in Google Scholar

EM-12-alkyne-C3-NH2 is a conjugate of the E3 ligase ligand Lenalidomide-Br (HY-43722) and linker. EM-12-alkyne-C3-NH2 can be conjugated with MI-1061 (HY-125858) to synthesize the PROTAC MD-224 (HY-114312).

For research use only. We do not sell to patients.

CAS No.: 2138440-39-6
Formula: C₁₈H₁₉N₃O₃
Molecular Weight:325.36

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Please store the product under the recommended conditions in the Certificate of Analysis.

EM-12-alkyne-C3-NH2 Chemical Structure

CAS No.: 2138440-39-6

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

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IC₅₀ & Target^[1]

Cereblon

All E3 Ligase Ligand-Linker Conjugates Isoforms :

Chemical Information

CAS No. 2138440-39-6
Molecular Weight 325.36
Formula C₁₈H₁₉N₃O₃
SMILES

O=C(C(N(CC1=C2C=CC=C1C#CCCCN)C2=O)CC3)NC3=O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (1)

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Nat Commun

PROTAC repurposing uncovers a noncanonical binding surface that mediates chemical degradation of nuclear receptors. [Abstract]

2025 Nov 6;16(1):9805. PMID: 41198675

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Handling Instructions (2659 KB)

References

[1]. Li Y, et al. Discovery of MD-224 as a First-in-Class, Highly Potent, and Efficacious Proteolysis TargetingChimera Murine Double Minute 2 Degrader Capable of Achieving Complete and Durable TumorRegression. J Med Chem. 2019 Jan 24;62(2):448-466. [Content Brief]

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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EM-12-alkyne-C3-NH2

1 Cited Publications

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EM-12-alkyne-C3-NH2

Publications Citing Use of MedChemExpress (MCE) EM-12-alkyne-C3-NH2

All E3 Ligase Ligand-Linker Conjugates Isoforms

Biological Activity

Chemical Information

Publications (1)

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EM-12-alkyne-C3-NH2 Related Classifications

HY-W591717 Related Classifications