1. PROTAC
  2. Ligand for E3 Ligase
  3. Lenalidomide-Br

Lenalidomide-Br 

Cat. No.: HY-43722 Purity: 98.99%
Handling Instructions

Lenalidomide-Br (Compound 41) is an analog of cereblon (CRBN) ligand Lenalidomide for E3 ubiquitin ligase, and is used in the recruitment of CRBN protein. Lenalidomide-Br can be connected to the ligand for protein by a linker to form PROTACs, such as the PROTAC STAT3 degrader SD-36 (HY-129602).

For research use only. We do not sell to patients.

Lenalidomide-Br Chemical Structure

Lenalidomide-Br Chemical Structure

CAS No. : 2093387-36-9

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Description

Lenalidomide-Br (Compound 41) is an analog of cereblon (CRBN) ligand Lenalidomide for E3 ubiquitin ligase, and is used in the recruitment of CRBN protein. Lenalidomide-Br can be connected to the ligand for protein by a linker to form PROTACs, such as the PROTAC STAT3 degrader SD-36 (HY-129602)[1][2].

IC50 & Target[1]

Cereblon

 

In Vitro

Lenalidomide-Br can be connected to the ligand for protein by a linker to form PROTACs. PROTACs are inducers of ubiquitination-mediated degradation of cancer-promoting proteins[1][2].

Molecular Weight

323.14

Formula

C₁₃H₁₁BrN₂O₃

CAS No.

2093387-36-9

SMILES

O=C(C(N(CC1=C2C=CC=C1Br)C2=O)CC3)NC3=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
References
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Keywords:

Lenalidomide-BrLigand for E3 LigaseE3 ligase-recruiting MoietycereblonanalogE3ubiquitinligaserecruitmentproteinPROTACInhibitorinhibitorinhibit

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Lenalidomide-Br
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HY-43722
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