2093387-36-9
2093387-36-9
Chemical Structure
Lenalidomide-Br
- CAS No.: 2093387-36-9
- Formula:C13H11BrN2O3
- Molecular Weight:323.14
IUPAC Name: 3-(4-bromo-1-oxoisoindolin-2-yl)piperidine-2,6-dione
InChIKey: SCZFMUWTABGOGF-UHFFFAOYSA-N
SMILES: O=C(C(N(CC1=C2C=CC=C1Br)C2=O)CC3)NC3=O
Biological Activity: Lenalidomide-Br (Compound 41) is an analog of cereblon (CRBN) ligand Lenalidomide for E3 ubiquitin ligase, and is used in the recruitment of CRBN protein. Lenalidomide-Br can be connected to the ligand for protein by a linker to form PROTACs, such as the PROTAC STAT3 degrader SD-36 (HY-129602)[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Lenalidomide-Br | 99.86% | Lenalidomide-Br (Compound 41) is an analog of cereblon (CRBN) ligand Lenalidomide for E3 ubiquitin ligase, and is used in the recruitment of CRBN protein. Lenalidomide-Br can be connected to the ligand for protein by a linker to form PROTACs, such as the PROTAC STAT3 degrader SD-36 (HY-129602). | ||||||||||||||||||||
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References
- [1]. Bai L, et al. A Potent and Selective Small-Molecule Degrader of STAT3 Achieves Complete Tumor Regression In Vivo. Cancer Cell. 2019 Nov 11;36(5):498-511.e17. [Content Brief]
- [2]. Zhou B, et al. Discovery of a Small-Molecule Degrader of Bromodomain and Extra-Terminal (BET) Proteins with Picomolar Cellular Potencies and Capable of Achieving Tumor Regression. J Med Chem. 2018 Jan 25;61(2):462-481. [Content Brief]
Keywords
