1. PROTAC
  2. Ligands for E3 Ligase
  3. Lenalidomide-I

Lenalidomide-I 

Cat. No.: HY-131318 Purity: 98.82%
Handling Instructions

Lenalidomide-I (Compound 72), an analog of cereblon (CRBN) ligand Lenalidomide for E3 ubiquitin ligase, is used in the recruitment of CRBN protein. Lenalidomide-I can be connected to the ligand for protein by a linker to form PROTACs, such as the PROTAC BET degrader QCA570 (HY-112609).

For research use only. We do not sell to patients.

Lenalidomide-I Chemical Structure

Lenalidomide-I Chemical Structure

CAS No. : 2207541-30-6

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Description

Lenalidomide-I (Compound 72), an analog of cereblon (CRBN) ligand Lenalidomide for E3 ubiquitin ligase, is used in the recruitment of CRBN protein. Lenalidomide-I can be connected to the ligand for protein by a linker to form PROTACs, such as the PROTAC BET degrader QCA570 (HY-112609)[1].

In Vitro

Lenalidomide-I can be connected to the ligand for protein by a linker to form PROTACs. PROTACs are inducers of ubiquitination-mediated degradation of cancer-promoting proteins[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

370.14

Formula

C₁₃H₁₁IN₂O₃

CAS No.
Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 25 mg/mL (67.54 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.7017 mL 13.5084 mL 27.0168 mL
5 mM 0.5403 mL 2.7017 mL 5.4034 mL
10 mM 0.2702 mL 1.3508 mL 2.7017 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: 2.5 mg/mL (6.75 mM); Suspended solution; Need ultrasonic

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (6.75 mM); Clear solution

*All of the co-solvents are provided by MCE.
References

Purity: 98.82%

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Product Name:
Lenalidomide-I
Cat. No.:
HY-131318
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