1. PROTAC
    Epigenetics
  2. PROTAC
    Epigenetic Reader Domain
  3. QCA570

QCA570 

Cat. No.: HY-112609 Purity: 99.69%
Handling Instructions

QCA570 is a potent BET degrader based on PROTAC, with an IC50 of 10 nM for BRD4 BD1 Protein.

For research use only. We do not sell to patients.

QCA570 Chemical Structure

QCA570 Chemical Structure

CAS No. : 2207569-08-0

Size Price Stock Quantity
5 mg USD 1850 In-stock
Estimated Time of Arrival: December 31
10 mg USD 3000 In-stock
Estimated Time of Arrival: December 31
50 mg   Get quote  
100 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

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Description

QCA570 is a potent BET degrader based on PROTAC, with an IC50 of 10 nM for BRD4 BD1 Protein.

IC50 & Target[1]

BRD4 BD1

10 nM (IC50)

In Vitro

QCA570 is an extremely potent and highly efficacious BET degrader, capable of degrading BET proteins at low picomolar (pM) concentrations in leukemia cells. QCA570 inhibits cell growth in MV4;11, MOLM-13, and RS4;11 cell lines with IC50 values of 8.3, 62, and 32 pM, respectively. QCA570 is the most potent and efficacious BET degrader reported to date[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

695.79

Formula

C₃₉H₃₃N₇O₄S

CAS No.

2207569-08-0

SMILES

O=C(N(C1CCC(NC1=O)=O)C2)C3=C2C(C#CCCCN4N=CC(C#CC(S5)=C(CC6=CC=CC=C6)C(COC7)=C5N8C7=NN=C8C)=C4)=CC=C3

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 40 mg/mL (57.49 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.4372 mL 7.1861 mL 14.3722 mL
5 mM 0.2874 mL 1.4372 mL 2.8744 mL
10 mM 0.1437 mL 0.7186 mL 1.4372 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: 2 mg/mL (2.87 mM); Suspended solution; Need ultrasonic

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2 mg/mL (2.87 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
Animal Administration
[1]

Mice[1]
Female SCID mice bearing RS4;11 xenograft tumors were dosed with a single intravenous dose of QCA570 (compound 35) at 5 mg/kg[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References

Purity: 99.69%

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Keywords:

QCA570QCA 570QCA-570PROTACEpigenetic Reader DomainProteolysis-targeting chimeraInhibitorinhibitorinhibit

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QCA570
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HY-112609
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