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QCA570 

Cat. No.: HY-112609
Handling Instructions

QCA570 is a potent BET degrader, with an IC50 of 10 nM for BRD4 BD1 Protein.

For research use only. We do not sell to patients.

QCA570 Chemical Structure

QCA570 Chemical Structure

CAS No. : 2207569-08-0

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Customer Review

  • Biological Activity

  • Protocol

  • Technical Information

  • Purity & Documentation

  • References

Description

QCA570 is a potent BET degrader, with an IC50 of 10 nM for BRD4 BD1 Protein.

IC50 & Target[1]

BRD4 BD1

10 nM (IC50)

In Vitro

QCA570 is an extremely potent and highly efficacious BET degrader, capable of degrading BET proteins at low picomolar (pM) concentrations in leukemia cells. QCA570 inhibits cell growth in MV4;11, MOLM-13, and RS4;11 cell lines with IC50 values of 8.3, 62, and 32 pM, respectively. QCA570 is the most potent and efficacious BET degrader reported to date[1].

Solvent & Solubility
In Vitro: 

10 mM in DMSO

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.4372 mL 7.1861 mL 14.3722 mL
5 mM 0.2874 mL 1.4372 mL 2.8744 mL
10 mM 0.1437 mL 0.7186 mL 1.4372 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Animal Administration
[1]

Mice[1]
Female SCID mice bearing RS4;11 xenograft tumors were dosed with a single intravenous dose of QCA570 (compound 35) at 5 mg/kg[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References
Molecular Weight

695.79

Formula

C₃₉H₃₃N₇O₄S

CAS No.

2207569-08-0

SMILES

O=C(N(C1CCC(NC1=O)=O)C2)C3=C2C(C#CCCCN4N=CC(C#CC(S5)=C(CC6=CC=CC=C6)C(COC7)=C5N8C7=NN=C8C)=C4)=CC=C3

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Shipping

Room temperature in continental US; may vary elsewhere

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Product Name:
QCA570
Cat. No.:
HY-112609
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QCA570

Cat. No.: HY-112609