1. Apoptosis
  2. MDM-2/p53
    Apoptosis
  3. MI-1061

MI-1061 

Cat. No.: HY-125858
Handling Instructions

MI-1061 is a potent, orally bioavailable, and chemically stable MDM2 (MDM2-p53 interaction) inhibitor (IC50=4.4 nM; Ki=0.16 nM). MI-1061 potently activates p53, induces apoptosis, and has anti-tumor activity.

For research use only. We do not sell to patients.

MI-1061 Chemical Structure

MI-1061 Chemical Structure

CAS No. : 1410737-34-6

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Description

MI-1061 is a potent, orally bioavailable, and chemically stable MDM2 (MDM2-p53 interaction) inhibitor (IC50=4.4 nM; Ki=0.16 nM). MI-1061 potently activates p53, induces apoptosis, and has anti-tumor activity[1].

IC50 & Target

IC50: 4.4 nM (MDM2)[1]
Ki: 0.16 nM (MDM2)

In Vitro

MI-1061 achieves IC50=100 and 250 nM in the SJSA-1 and HCT-116 p53+/+ cell lines, respectively, and has IC50>10000 nM in the p53 knockout cell line HCT-116 p53–/–cell line[1].

In Vivo

MI-1061 is capable of achieving tumor regression in the SJSA-1 xenograft tumor model in mice with oral administration[1].

Molecular Weight

582.45

Formula

C₃₀H₂₆Cl₂FN₃O₄

CAS No.

1410737-34-6

SMILES

O=C(O)C1=CC=C(NC([[email protected]](N2)[[email protected]](C3=CC=CC(Cl)=C3F)[[email protected]]4(C(NC5=C4C=CC(Cl)=C5)=O)C62CCCCC6)=O)C=C1

Shipping

Room temperature in continental US; may vary elsewhere

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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