1. Apoptosis
    Metabolic Enzyme/Protease
  2. MDM-2/p53
    E1/E2/E3 Enzyme
    Apoptosis
  3. MI-1061

MI-1061 

Cat. No.: HY-125858 Purity: 99.62% ee.: 100%
Handling Instructions

MI-1061 is a potent, orally bioavailable, and chemically stable MDM2 (MDM2-p53 interaction) inhibitor (IC50=4.4 nM; Ki=0.16 nM). MI-1061 potently activates p53 and induces apoptosis in the SJSA-1 xenograft tumor tissue in mice. Anti-tumor activity.

For research use only. We do not sell to patients.

MI-1061 Chemical Structure

MI-1061 Chemical Structure

CAS No. : 1410737-34-6

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 1256 In-stock
Estimated Time of Arrival: December 31
1 mg USD 550 In-stock
Estimated Time of Arrival: December 31
5 mg USD 980 In-stock
Estimated Time of Arrival: December 31
10 mg USD 1500 In-stock
Estimated Time of Arrival: December 31
50 mg   Get quote  
100 mg   Get quote  

* Please select Quantity before adding items.

Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of MI-1061:

Top Publications Citing Use of Products
  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

MI-1061 is a potent, orally bioavailable, and chemically stable MDM2 (MDM2-p53 interaction) inhibitor (IC50=4.4 nM; Ki=0.16 nM). MI-1061 potently activates p53 and induces apoptosis in the SJSA-1 xenograft tumor tissue in mice. Anti-tumor activity[1].

IC50 & Target

IC50: 4.4 nM (MDM2)[1]
Ki: 0.16 nM (MDM2)

In Vitro

MI-1061 achieves IC50=100 and 250 nM in the SJSA-1 and HCT-116 p53+/+ cell lines, respectively, and has IC50>10000 nM in the p53 knockout cell line HCT-116 p53–/–cell line[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

MI-1061 (100 mg/kg; p.o.; daily for 14 days) is capable of achieving tumor regression in the SJSA-1 xenograft tumor model in mice[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: SCID mice bearing SJSA-1 osteosarcoma xenografts[1]
Dosage: 100 mg/kg
Administration: P.o.; daily for 14 days
Result: Demonstrated strong antitumor activity and achieved significant tumor regression.
Molecular Weight

582.45

Formula

C₃₀H₂₆Cl₂FN₃O₄

CAS No.

1410737-34-6

SMILES

O=C(O)C1=CC=C(NC([[email protected]](N2)[[email protected]](C3=CC=CC(Cl)=C3F)[[email protected]]4(C(NC5=C4C=CC(Cl)=C5)=O)C62CCCCC6)=O)C=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 160 mg/mL (274.70 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.7169 mL 8.5844 mL 17.1689 mL
5 mM 0.3434 mL 1.7169 mL 3.4338 mL
10 mM 0.1717 mL 0.8584 mL 1.7169 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 4 mg/mL (6.87 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: 4 mg/mL (6.87 mM); Suspended solution; Need ultrasonic

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 4 mg/mL (6.87 mM); Clear solution

*All of the co-solvents are provided by MCE.
References

Purity: 99.62% ee.: 100%

  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.
  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

MI-1061MI1061MI 1061MDM-2/p53E1/E2/E3 EnzymeApoptosisE1 activating enzymeE2 conjugating enzymeE3 ligating enzymeUbiquitin activating enzymeUbiquitin conjugating enzymeUbiquitin ligaseSJSA-1xenografttumortissueSCIDmiceproteininteractionoralInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

 

Salutation

Applicant Name *

 

Email address *

Phone number *

 

Organization name *

Department *

 

Requested quantity *

Country or Region *

     

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
MI-1061
Cat. No.:
HY-125858
Quantity:
MCE Japan Authorized Agent: