1. Apoptosis
    Metabolic Enzyme/Protease
  2. MDM-2/p53
    E1/E2/E3 Enzyme
    Apoptosis
  3. MI-1061 TFA

MI-1061 TFA 

Cat. No.: HY-125858A
Handling Instructions

MI-1061 TFA is a potent, orally bioavailable, and chemically stable MDM2 (MDM2-p53 interaction) inhibitor (IC50=4.4 nM; Ki=0.16 nM). MI-1061 TFA potently activates p53 and induces apoptosis in the SJSA-1 xenograft tumor tissue in mice. Anti-tumor activity.

For research use only. We do not sell to patients.

MI-1061 TFA Chemical Structure

MI-1061 TFA Chemical Structure

CAS No. : 1410737-35-7

Size Price Stock Quantity
1 mg USD 550 In-stock
Estimated Time of Arrival: December 31
5 mg USD 980 In-stock
Estimated Time of Arrival: December 31
10 mg USD 1500 In-stock
Estimated Time of Arrival: December 31
50 mg   Get quote  
100 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of MI-1061 TFA:

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Description

MI-1061 TFA is a potent, orally bioavailable, and chemically stable MDM2 (MDM2-p53 interaction) inhibitor (IC50=4.4 nM; Ki=0.16 nM). MI-1061 TFA potently activates p53 and induces apoptosis in the SJSA-1 xenograft tumor tissue in mice. Anti-tumor activity[1].

In Vitro

MI-1061 achieves IC50=100 and 250 nM in the SJSA-1 and HCT-116 p53+/+ cell lines, respectively, and has IC50>10000 nM in the p53 knockout cell line HCT-116 p53–/–cell line[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

MI-1061 (100 mg/kg; p.o.; daily for 14 days) is capable of achieving tumor regression in the SJSA-1 xenograft tumor model in mice[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: SCID mice bearing SJSA-1 osteosarcoma xenografts[1]
Dosage: 100 mg/kg
Administration: P.o.; daily for 14 days
Result: Demonstrated strong antitumor activity and achieved significant tumor regression.
Molecular Weight

696.47

Formula

C₃₂H₂₇Cl₂F₄N₃O₆

CAS No.

1410737-35-7

SMILES

O=C(O)C1=CC=C(NC([[email protected]](N2)[[email protected]](C3=CC=CC(Cl)=C3F)[[email protected]]4(C(NC5=C4C=CC(Cl)=C5)=O)C62CCCCC6)=O)C=C1.OC(C(F)(F)F)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent & Solubility
In Vitro: 

DMSO : 120 mg/mL (172.30 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.4358 mL 7.1791 mL 14.3581 mL
5 mM 0.2872 mL 1.4358 mL 2.8716 mL
10 mM 0.1436 mL 0.7179 mL 1.4358 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 3 mg/mL (4.31 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 3 mg/mL (4.31 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

MI-1061MI1061MI 1061MDM-2/p53E1/E2/E3 EnzymeApoptosisE1 activating enzymeE2 conjugating enzymeE3 ligating enzymeUbiquitin activating enzymeUbiquitin conjugating enzymeUbiquitin ligaseSJSA-1xenografttumortissueSCIDmiceproteininteractionoralInhibitorinhibitorinhibit

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MI-1061 TFA
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HY-125858A
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