(S,R,S)-AHPC-PEG2-NH2 hydrochloride
Based on 1 Customer Validation
(S,R,S)-AHPC-PEG2-NH2 hydrochloride (VH032-PEG2-NH2 hydrochloride) is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and 2-unit PEG linker used in the synthesis of PROTACs.
For research use only. We do not sell to patients.
- Purity: 99.22%
- CAS No.: 2097973-72-1
- Formula: C28H42ClN5O6S
- Molecular Weight:612.18
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Storage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
All E3 Ligase Ligand-Linker Conjugates Isoforms
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Biological Activity
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VHL |
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2097973-72-1
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Appearance Solid
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Molecular Weight 612.18
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Formula C28H42ClN5O6S
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Color White to yellow
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SMILES
O=C([C@H]1N(C([C@@H](NC(COCCOCCN)=O)C(C)(C)C)=O)C[C@H](O)C1)NCC2=CC=C(C3=C(C)N=CS3)C=C2.[H]Cl
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Synonyms
VH032-PEG2-NH2 hydrochloride; VHL Ligand-Linker Conjugates 3 hydrochloride; E3 ligase Ligand-Linker Conjugates 6
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
H2O : 100 mg/mL (163.35 mM; Need ultrasonic)
DMSO : 100 mg/mL (163.35 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (275 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
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Handling Instructions (2659 KB)
References
[1]. Chan KH, et al. Impact of Target Warhead and Linkage Vector on Inducing Protein Degradation: Comparison of Bromodomain and Extra-Terminal (BET) Degraders Derived from Triazolodiazepine (JQ1) and Tetrahydroquinoline (I-BET726) BET Inhibitor Scaffolds. J Med Chem. 2018 Jan 25;61(2):504-513. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O / DMSO | 1 mM | 1.6335 mL | 8.1675 mL | 16.3351 mL | 40.8377 mL |
| 5 mM | 0.3267 mL | 1.6335 mL | 3.2670 mL | 8.1675 mL | |
| 10 mM | 0.1634 mL | 0.8168 mL | 1.6335 mL | 4.0838 mL | |
| 15 mM | 0.1089 mL | 0.5445 mL | 1.0890 mL | 2.7225 mL | |
| 20 mM | 0.0817 mL | 0.4084 mL | 0.8168 mL | 2.0419 mL | |
| 25 mM | 0.0653 mL | 0.3267 mL | 0.6534 mL | 1.6335 mL | |
| 30 mM | 0.0545 mL | 0.2723 mL | 0.5445 mL | 1.3613 mL | |
| 40 mM | 0.0408 mL | 0.2042 mL | 0.4084 mL | 1.0209 mL | |
| 50 mM | 0.0327 mL | 0.1634 mL | 0.3267 mL | 0.8168 mL | |
| 60 mM | 0.0272 mL | 0.1361 mL | 0.2723 mL | 0.6806 mL | |
| 80 mM | 0.0204 mL | 0.1021 mL | 0.2042 mL | 0.5105 mL | |
| 100 mM | 0.0163 mL | 0.0817 mL | 0.1634 mL | 0.4084 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
(S,R,S)-AHPC-PEG2-NH2 hydrochloride Related Classifications
HY-103603 Related Classifications
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