2. PROTAC
  3. E3 Ligase Ligand-Linker Conjugates
  4. (S,R,S)-AHPC-PEG2-NH2 hydrochloride

(S,R,S)-AHPC-PEG2-NH2 (hydrochloride)  (Synonyms: VH032-PEG2-NH2 (hydrochloride); VHL Ligand-Linker Conjugates 3 (hydrochloride); E3 ligase Ligand-Linker Conjugates 6)

製品番号: HY-103603 純度: 99.22%
COA 取扱説明書 Technical Support

(S,R,S)-AHPC-PEG2-NH2 hydrochloride (VH032-PEG2-NH2 hydrochloride) is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and 2-unit PEG linker used in the synthesis of PROTACs.

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(S,R,S)-AHPC-PEG2-NH2 hydrochloride

(S,R,S)-AHPC-PEG2-NH2 (hydrochloride) 構造式

CAS 番号 : 2097973-72-1

容量 価格（税別） 在庫状況 数量
>無料サンプル (0.1 - 0.2 mg)   今すぐ申し込む  
50 mg $220 在庫あり
100 mg $310 在庫あり
500 mg $760 在庫あり
1 g   お問い合わせ  
5 g   お問い合わせ  

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Other Forms of (S,R,S)-AHPC-PEG2-NH2 hydrochloride:

(S,R,S)-AHPC-PEG2-NH2 (hydrochloride) 関連抗体

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von Hippel-Lindau (VHL) MDM2 Cereblon cIAP1 Aryl Hydrocarbon Receptor TRIM21

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製品説明

(S,R,S)-AHPC-PEG2-NH2 hydrochloride (VH032-PEG2-NH2 hydrochloride) is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and 2-unit PEG linker used in the synthesis of PROTACs[1].

IC50 & Target[1]

VHL

 

体外実験

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

(S,R,S)-AHPC-PEG2-NH2 (hydrochloride) 関連抗体
分子量

612.18

分子式

C28H42ClN5O6S
CAS 番号
Appearance

Solid

Color

White to yellow

SMILES

O=C([C@H]1N(C([C@@H](NC(COCCOCCN)=O)C(C)(C)C)=O)C[C@H](O)C1)NCC2=CC=C(C3=C(C)N=CS3)C=C2.[H]Cl
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
溶剤 & 溶解度
体外: 

H2O : 100 mg/mL (163.35 mM; Need ultrasonic)

DMSO : 100 mg/mL (163.35 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.6335 mL 8.1675 mL 16.3351 mL
5 mM 0.3267 mL 1.6335 mL 3.2670 mL
10 mM 0.1634 mL 0.8168 mL 1.6335 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始）

C1

×
体積 （開始）

V1

=
濃度 （終了）

C2

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体積 （終了）

V2

In Vivo Dissolution Calculator
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Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
純度とドキュメンテーション

純度: 99.77%

COA (254 KB) HNMR (133 KB) LCMS (245 KB)

取扱説明書 (2659 KB)
参考文献

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O / DMSO 1 mM 1.6335 mL 8.1675 mL 16.3351 mL 40.8377 mL
5 mM 0.3267 mL 1.6335 mL 3.2670 mL 8.1675 mL
10 mM 0.1634 mL 0.8168 mL 1.6335 mL 4.0838 mL
15 mM 0.1089 mL 0.5445 mL 1.0890 mL 2.7225 mL
20 mM 0.0817 mL 0.4084 mL 0.8168 mL 2.0419 mL
25 mM 0.0653 mL 0.3267 mL 0.6534 mL 1.6335 mL
30 mM 0.0545 mL 0.2723 mL 0.5445 mL 1.3613 mL
40 mM 0.0408 mL 0.2042 mL 0.4084 mL 1.0209 mL
50 mM 0.0327 mL 0.1634 mL 0.3267 mL 0.8168 mL
60 mM 0.0272 mL 0.1361 mL 0.2723 mL 0.6806 mL
80 mM 0.0204 mL 0.1021 mL 0.2042 mL 0.5105 mL
100 mM 0.0163 mL 0.0817 mL 0.1634 mL 0.4084 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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(S,R,S)-AHPC-PEG2-NH2 hydrochloride Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量   濃度   体積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(S,R,S)-AHPC-PEG2-NH22097973-72-1VH032-PEG2-NH2VHL Ligand-Linker Conjugates 3 E3 ligase Ligand-Linker Conjugates 6E3 Ligase Ligand-Linker ConjugatesInhibitorinhibitorinhibit

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製品名:
(S,R,S)-AHPC-PEG2-NH2 hydrochloride
製品番号:
HY-103603
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