2. PROTAC
  3. E3 Ligase Ligand-Linker Conjugates
  4. Thalidomide-O-amido-PEG3-C2-NH2 TFA

Thalidomide-O-amido-PEG3-C2-NH2 TFA  (Synonyms: Cereblon Ligand-Linker Conjugates 3 TFA; E3 ligase Ligand-Linker Conjugates 14 TFA)

Cat. No.: HY-103611 Purity: 99.55%
COA Handling Instructions

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Thalidomide-O-amido-PEG3-C2-NH2 TFA is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and 3-unit PEG linker used in PROTAC technology.

For research use only. We do not sell to patients.

Thalidomide-O-amido-PEG3-C2-NH2 TFA Chemical Structure

Thalidomide-O-amido-PEG3-C2-NH2 TFA Chemical Structure

CAS No. : 1957236-21-3

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Based on 1 publication(s) in Google Scholar

Other Forms of Thalidomide-O-amido-PEG3-C2-NH2 TFA:

Thalidomide-O-amido-PEG3-C2-NH2 TFA Related Antibodies

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von Hippel-Lindau (VHL) MDM2 Cereblon cIAP1 Aryl Hydrocarbon Receptor

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Description

Thalidomide-O-amido-PEG3-C2-NH2 TFA is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and 3-unit PEG linker used in PROTAC technology.

IC50 & Target

Cereblon

 

Molecular Weight

620.53

Formula

C25H31F3N4O11
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(N(C(CCC1=O)C(N1)=O)C2=O)C(C2=CC=C3)=C3OCC(NCCOCCOCCOCCN)=O.FC(F)(F)C(O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (80.58 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.6115 mL 8.0576 mL 16.1153 mL
5 mM 0.3223 mL 1.6115 mL 3.2231 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.55%

COA (246 KB) LCMS (106 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.6115 mL 8.0576 mL 16.1153 mL 40.2881 mL
5 mM 0.3223 mL 1.6115 mL 3.2231 mL 8.0576 mL
10 mM 0.1612 mL 0.8058 mL 1.6115 mL 4.0288 mL
15 mM 0.1074 mL 0.5372 mL 1.0744 mL 2.6859 mL
20 mM 0.0806 mL 0.4029 mL 0.8058 mL 2.0144 mL
25 mM 0.0645 mL 0.3223 mL 0.6446 mL 1.6115 mL
30 mM 0.0537 mL 0.2686 mL 0.5372 mL 1.3429 mL
40 mM 0.0403 mL 0.2014 mL 0.4029 mL 1.0072 mL
50 mM 0.0322 mL 0.1612 mL 0.3223 mL 0.8058 mL
60 mM 0.0269 mL 0.1343 mL 0.2686 mL 0.6715 mL
80 mM 0.0201 mL 0.1007 mL 0.2014 mL 0.5036 mL
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Thalidomide-O-amido-PEG3-C2-NH2 TFA Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Thalidomide-O-amido-PEG3-C2-NH21957236-21-3Cereblon Ligand-Linker Conjugates 3E3 ligase Ligand-Linker Conjugates 14E3 Ligase Ligand-Linker ConjugatesInhibitorinhibitorinhibit

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