1. PROTAC
  2. E3 Ligase Ligand-Linker Conjugate
  3. Thalidomide-O-amido-PEG3-C2-NH2 (TFA)

Thalidomide-O-amido-PEG3-C2-NH2 (TFA) (Synonyms: Cereblon Ligand-Linker Conjugates 3 (TFA); E3 ligase Ligand-Linker Conjugates 14 (TFA))

Cat. No.: HY-103611 Purity: 99.04%
Handling Instructions

Thalidomide-O-amido-PEG3-C2-NH2 TFA is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and 3-unit PEG linker used in PROTAC technology.

For research use only. We do not sell to patients.

Thalidomide-O-amido-PEG3-C2-NH2 (TFA) Chemical Structure

Thalidomide-O-amido-PEG3-C2-NH2 (TFA) Chemical Structure

CAS No. : 1957236-21-3

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Description

Thalidomide-O-amido-PEG3-C2-NH2 TFA is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and 3-unit PEG linker used in PROTAC technology.

IC50 & Target[1]

Cereblon

 

Molecular Weight

620.53

Formula

C₂₅H₃₁F₃N₄O₁₁

CAS No.

1957236-21-3

SMILES

O=C(N(C(CCC1=O)C(N1)=O)C2=O)C(C2=CC=C3)=C3OCC(NCCOCCOCCOCCN)=O.FC(F)(F)C(O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (80.58 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.6115 mL 8.0576 mL 16.1153 mL
5 mM 0.3223 mL 1.6115 mL 3.2231 mL
10 mM 0.1612 mL 0.8058 mL 1.6115 mL
*Please refer to the solubility information to select the appropriate solvent.
References

Purity: 99.04%

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Keywords:

Thalidomide-O-amido-PEG3-C2-NH2 (TFA)Cereblon Ligand-Linker Conjugates 3E3 ligase Ligand-Linker Conjugates 14E3 Ligase Ligand-Linker ConjugateInhibitorinhibitorinhibit

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Product Name:
Thalidomide-O-amido-PEG3-C2-NH2 (TFA)
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HY-103611
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