2. PROTAC
  3. E3 Ligase Ligand-Linker Conjugates
  4. Pomalidomide-PEG4-C-COOH

Pomalidomide-PEG4-C-COOH  (Synonyms: Cereblon Ligand -Linker Conjugates 1; E3 Ligase Ligand-Linker Conjugates 1)

Cat. No.: HY-21930 Purity: 99.16%
COA
SDS
Handling Instructions Technical Support

Pomalidomide-PEG4-C-COOH (Cereblon Ligand -Linker Conjugate 1) is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and 4-unit PEG linker used in PROTAC technology.

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Pomalidomide-PEG4-C-COOH

Pomalidomide-PEG4-C-COOH 화학구조

CAS No. : 2097938-44-6

사이즈 가격 재고 수량
25 mg 해외재고보유
50 mg 해외재고보유
100 mg 해외재고보유
250 mg 해외재고보유
500 mg   견적 받기  
1 g   견적 받기  

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

This product is a controlled substance and not for sale in your territory.

고객리뷰

Based on 1 Customer Validation

Pomalidomide-PEG4-C-COOH Related Antibodies

Top Publications Citing Use of Products

View All E3 Ligase Ligand-Linker Conjugates Isoform Specific Products:

View All Isoforms
von Hippel-Lindau (VHL) MDM2 Cereblon cIAP1 Aryl Hydrocarbon Receptor TRIM21

  • Biological Activity

  • 순도&문서

  • References

  • 고객리뷰

제품 설명

Pomalidomide-PEG4-C-COOH (Cereblon Ligand -Linker Conjugate 1) is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and 4-unit PEG linker used in PROTAC technology.

IC50 & Target[1]

Cereblon

 

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Pomalidomide-PEG4-C-COOH Related Antibodies
분자량

507.49

화학식

C23H29N3O10
CAS No.
Appearance

Oil

Color

Light yellow to yellow

SMILES

O=C(N(C(CCC1=O)C(N1)=O)C2=O)C(C2=CC=C3)=C3NCCOCCOCCOCCOCC(O)=O
선적

Room temperature in continental US; may vary elsewhere.
보관

4°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

용액&용해도
In Vitro: 

DMSO : 50 mg/mL (98.52 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Ethanol : 25 mg/mL (49.26 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.9705 mL 9.8524 mL 19.7048 mL
5 mM 0.3941 mL 1.9705 mL 3.9410 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • 몰농도 계산기

  • 농도 희석 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
순도&문서

Purity: 99.19%

SDS (394 KB)

COA (243 KB) HNMR (146 KB) LCMS (95 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
Ethanol / DMSO 1 mM 1.9705 mL 9.8524 mL 19.7048 mL 49.2621 mL
5 mM 0.3941 mL 1.9705 mL 3.9410 mL 9.8524 mL
10 mM 0.1970 mL 0.9852 mL 1.9705 mL 4.9262 mL
15 mM 0.1314 mL 0.6568 mL 1.3137 mL 3.2841 mL
20 mM 0.0985 mL 0.4926 mL 0.9852 mL 2.4631 mL
25 mM 0.0788 mL 0.3941 mL 0.7882 mL 1.9705 mL
30 mM 0.0657 mL 0.3284 mL 0.6568 mL 1.6421 mL
40 mM 0.0493 mL 0.2463 mL 0.4926 mL 1.2316 mL
DMSO 50 mM 0.0394 mL 0.1970 mL 0.3941 mL 0.9852 mL
60 mM 0.0328 mL 0.1642 mL 0.3284 mL 0.8210 mL
80 mM 0.0246 mL 0.1232 mL 0.2463 mL 0.6158 mL
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Pomalidomide-PEG4-C-COOH Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Pomalidomide-PEG4-C-COOH2097938-44-6Cereblon Ligand -Linker Conjugates 1 E3 Ligase Ligand-Linker Conjugates 1E3 Ligase Ligand-Linker ConjugatesInhibitorinhibitorinhibit

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상품명:
Pomalidomide-PEG4-C-COOH
Cat. No.:
HY-21930
수량:
MCE Japan Authorized Agent:

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SAFETY DATA SHEET (SDS)

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