2. PROTAC
  3. E3 Ligase Ligand-Linker Conjugates
  4. (S,R,S)-AHPC-PEG3-NH2 hydrochloride

(S,R,S)-AHPC-PEG3-NH2 hydrochloride  (Synonyms: VH032-PEG3-NH2 hydrochloride; VHL Ligand-Linker Conjugates 1 hydrochloride; E3 ligase Ligand-Linker Conjugates 5)

Cat. No.: HY-103602 Purity: 98.20%
COA Handling Instructions

(S,R,S)-AHPC-PEG3-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and 3-unit PEG linker used in PROTAC technology.

For research use only. We do not sell to patients.

(S,R,S)-AHPC-PEG3-NH2 hydrochloride Chemical Structure

(S,R,S)-AHPC-PEG3-NH2 hydrochloride Chemical Structure

CAS No. : 2097971-11-2

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Based on 1 publication(s) in Google Scholar

Other Forms of (S,R,S)-AHPC-PEG3-NH2 hydrochloride:

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von Hippel-Lindau (VHL) MDM2 Cereblon cIAP1

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Description

(S,R,S)-AHPC-PEG3-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and 3-unit PEG linker used in PROTAC technology.

IC50 & Target

VHL

 

Molecular Weight

656.23

Appearance

Solid

Formula

C30H46ClN5O7S
CAS No.
SMILES

O=C([[email protected]]1N(C([[email protected]](C(C)(C)C)NC(COCCOCCOCCN)=O)=O)C[[email protected]](O)C1)NCC2=CC=C(C3=C(C)N=CS3)C=C2.[H]Cl
Shipping

Shipping with dry ice.
Storage

-80°C, protect from light, stored under nitrogen
Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (76.19 mM; Need ultrasonic)

H2O : ≥ 50 mg/mL (76.19 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.5239 mL 7.6193 mL 15.2386 mL
5 mM 0.3048 mL 1.5239 mL 3.0477 mL
10 mM 0.1524 mL 0.7619 mL 1.5239 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  PBS

    Solubility: 50 mg/mL (76.19 mM); Clear solution; Need ultrasonic

*All of the co-solvents are available by MCE.
Purity & Documentation

Purity: 98.20%

COA (250 KB) HNMR (173 KB) LCMS (106 KB)

Handling Instructions (2659 KB)
References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

(S,R,S)-AHPC-PEG3-NH22097971-11-2VH032-PEG3-NH2VHL Ligand-Linker Conjugates 1 E3 ligase Ligand-Linker Conjugates 5E3 Ligase Ligand-Linker ConjugatesInhibitorinhibitorinhibit

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