(S,R,S)-AHPC-PEG3-NH2 hydrochloride
Based on 1 Customer Validation
(S,R,S)-AHPC-PEG3-NH2 (VH032-PEG3-NH2) hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and 3-unit PEG linker used in PROTAC technology.
For research use only. We do not sell to patients.
- Purity: 99.01%
- CAS No.: 2097971-11-2
- Formula: C30H46ClN5O7S
- Molecular Weight:656.23
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Storage:
-80°C, protect from light, stored under nitrogen
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
All E3 Ligase Ligand-Linker Conjugates Isoforms
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Biological Activity
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VHL |
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2097971-11-2
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Appearance Solid
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Molecular Weight 656.23
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Formula C30H46ClN5O7S
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Color Light yellow to yellow
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SMILES
O=C([C@H]1N(C([C@H](C(C)(C)C)NC(COCCOCCOCCN)=O)=O)C[C@H](O)C1)NCC2=CC=C(C3=C(C)N=CS3)C=C2.[H]Cl
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Synonyms
VH032-PEG3-NH2 hydrochloride; VHL Ligand-Linker Conjugates 1 hydrochloride; E3 ligase Ligand-Linker Conjugates 5
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Shipping
Shipping with dry ice.
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Storage
-80°C, protect from light, stored under nitrogen
Solvent & Solubility
DMSO : 200 mg/mL (304.77 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
For the following dissolution methods, please prepare the working solution directly:
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: PBS
Solubility: 50 mg/mL (76.19 mM); Clear solution; Need ultrasonic
Purity & Documentation
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Data Sheet (273 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
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Handling Instructions (2659 KB)
References
[1]. Chan KH, et al. Impact of Target Warhead and Linkage Vector on Inducing Protein Degradation: Comparison of Bromodomain and Extra-Terminal (BET) Degraders Derived from Triazolodiazepine (JQ1) and Tetrahydroquinoline (I-BET726) BET Inhibitor Scaffolds. J Med Chem. 2018 Jan 25;61(2):504-513. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.5239 mL | 7.6193 mL | 15.2386 mL | 38.0964 mL |
| 5 mM | 0.3048 mL | 1.5239 mL | 3.0477 mL | 7.6193 mL | |
| 10 mM | 0.1524 mL | 0.7619 mL | 1.5239 mL | 3.8096 mL | |
| 15 mM | 0.1016 mL | 0.5080 mL | 1.0159 mL | 2.5398 mL | |
| 20 mM | 0.0762 mL | 0.3810 mL | 0.7619 mL | 1.9048 mL | |
| 25 mM | 0.0610 mL | 0.3048 mL | 0.6095 mL | 1.5239 mL | |
| 30 mM | 0.0508 mL | 0.2540 mL | 0.5080 mL | 1.2699 mL | |
| 40 mM | 0.0381 mL | 0.1905 mL | 0.3810 mL | 0.9524 mL | |
| 50 mM | 0.0305 mL | 0.1524 mL | 0.3048 mL | 0.7619 mL | |
| 60 mM | 0.0254 mL | 0.1270 mL | 0.2540 mL | 0.6349 mL | |
| 80 mM | 0.0190 mL | 0.0952 mL | 0.1905 mL | 0.4762 mL | |
| 100 mM | 0.0152 mL | 0.0762 mL | 0.1524 mL | 0.3810 mL |
(S,R,S)-AHPC-PEG3-NH2 hydrochloride Related Classifications
HY-103602 Related Classifications
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