(S,R,S)-AHPC-phenol-alkylC6-amine dihydrochloride
Based on 1 Customer Validation
(S,R,S)-AHPC-phenol-alkylC6-amine dihydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the VH032 based VHL ligand and an alkyl linker used for PROTAC degrader.
For research use only. We do not sell to patients.
- Purity : 96.35%
- CAS No.: 2376990-28-0
- Formula: C30H47Cl2N5O5S
- Molecular Weight:660.70
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Storage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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HY-136184
(S,R,S)-AHPC-phenol-C4-NH2 dihydrochlorideE3 Ligase Ligand-Linker Conjugates -
HY-103602
(S,R,S)-AHPC-PEG3-NH2 hydrochlorideE3 Ligase Ligand-Linker Conjugate -
HY-103604A
(S,R,S)-AHPC-PEG4-NH2E3 ligase ligand-linker conjugate -
HY-133487B
(S,R,S)-AHPC-C8-NH2E3 Ligase Ligand-Linker Conjugate -
HY-130711B
(S,R,S)-AHPC-C3-NH2 hydrochlorideE3 Ligase Ligand-Linker Conjugates -
HY-103603
(S,R,S)-AHPC-PEG2-NH2 hydrochlorideE3 ligase ligand-linker conjugate -
HY-129703A
Thalidomide-PEG2-C2-NH2 TFAE3 Ligase Ligand-linker Conjugate -
HY-131387
(S,R,S)-AHPC-Me-CO-CH2-PEG3-NH2E3 Ligase Ligand-Linker Conjugates -
HY-139218
(S,R,S)-AHPC-Me-C6-NH2E3 Ligase Ligand-Linker Conjugates -
HY-138550A
(S,R,S)-AHPC-3-methylbutanyl acetate-methanesulfonothioate-PEG3-NH2 TFAE3 Ligase Ligand-Linker Conjugate -
HY-136163
(S,R,S)-AHPC-C2-NH2 dihydrochlorideE3 Ligase Ligand-Linker Conjugates -
HY-135045
(S,R,S)-AHPC-C4-COOHE3 Ligase Ligand-Linker Conjugate
All E3 Ligase Ligand-Linker Conjugates Isoforms
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Biological Activity
Description
Chemical Information
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CAS No. 2376990-28-0
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Appearance Solid
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Molecular Weight 660.70
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Formula C30H47Cl2N5O5S
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Color Light yellow to yellow
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SMILES
[H]Cl.O=C(NCC1=CC=C(C2=C(C)N=CS2)C=C1OCCCCCCN)[C@H]3N(C([C@H](C(C)(C)C)NC(C)=O)=O)C[C@H](O)C3.[H]Cl
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Synonyms
VH032 phenol-alkylC6-amine dihydrochloride
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
In Vitro:
DMSO : 200 mg/mL (302.71 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
In Vivo:
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: 5 mg/mL (7.57 mM); Clear solution; Need ultrasonic
This protocol yields a clear solution of 5 mg/mL.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (50.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: 5 mg/mL (7.57 mM); Clear solution; Need ultrasonic
This protocol yields a clear solution of 5 mg/mL.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (50.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL. * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
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Data Sheet (276 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
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Handling Instructions (2659 KB)
References
[1]. Sato T, et al. Cereblon-Based Small-Molecule Compounds to Control Neural Stem Cell Proliferation in Regenerative Medicine. Front Cell Dev Biol. 2021;9:629326. Published 2021 Mar 11. [Content Brief]
[2]. Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.5135 mL | 7.5677 mL | 15.1355 mL | 37.8387 mL |
| 5 mM | 0.3027 mL | 1.5135 mL | 3.0271 mL | 7.5677 mL | |
| 10 mM | 0.1514 mL | 0.7568 mL | 1.5135 mL | 3.7839 mL | |
| 15 mM | 0.1009 mL | 0.5045 mL | 1.0090 mL | 2.5226 mL | |
| 20 mM | 0.0757 mL | 0.3784 mL | 0.7568 mL | 1.8919 mL | |
| 25 mM | 0.0605 mL | 0.3027 mL | 0.6054 mL | 1.5135 mL | |
| 30 mM | 0.0505 mL | 0.2523 mL | 0.5045 mL | 1.2613 mL | |
| 40 mM | 0.0378 mL | 0.1892 mL | 0.3784 mL | 0.9460 mL | |
| 50 mM | 0.0303 mL | 0.1514 mL | 0.3027 mL | 0.7568 mL | |
| 60 mM | 0.0252 mL | 0.1261 mL | 0.2523 mL | 0.6306 mL | |
| 80 mM | 0.0189 mL | 0.0946 mL | 0.1892 mL | 0.4730 mL | |
| 100 mM | 0.0151 mL | 0.0757 mL | 0.1514 mL | 0.3784 mL |
(S,R,S)-AHPC-phenol-alkylC6-amine dihydrochloride Related Classifications
HY-136183 Related Classifications
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