2. PROTAC
  3. E3 Ligase Ligand-Linker Conjugates
  4. (S,R,S)-AHPC-Me-C6-NH2

(S,R,S)-AHPC-Me-C6-NH2 is a VHL E3 ubiquitin ligase ligand-linker conjugate structurally modified based on VHL ligand 2 (HY-112078). (S,R,S)-AHPC-Me-C6-NH2 can be used for the synthesis of PROTACs.

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(S,R,S)-AHPC-Me-C6-NH2

(S,R,S)-AHPC-Me-C6-NH2 構造式

CAS 番号 : 2411422-49-4

容量 価格（税別） 在庫状況 数量
>無料サンプル (0.1 - 0.2 mg)   今すぐ申し込む  
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 275 在庫あり
Solution
10 mM * 1 mL in DMSO USD 275 在庫あり
Solid
25 mg $250 在庫あり
50 mg $400 在庫あり
100 mg $600 在庫あり
200 mg   お問い合わせ  
500 mg   お問い合わせ  

* アイテムを追加する前、数量をご選択ください

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(S,R,S)-AHPC-Me-C6-NH2 関連抗体

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von Hippel-Lindau (VHL) MDM2 Cereblon cIAP1 Aryl Hydrocarbon Receptor TRIM21

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製品説明

(S,R,S)-AHPC-Me-C6-NH2 is a VHL E3 ubiquitin ligase ligand-linker conjugate structurally modified based on VHL ligand 2 (HY-112078). (S,R,S)-AHPC-Me-C6-NH2 can be used for the synthesis of PROTACs[1][2].
体外実験

(S,R,S)-AHPC-Me-C6-NH2 is used to couple with oseltamivir moieties via amide condensation to construct Oseltamivir (HY-13317)-PROTACs, which induce the degradation of viral neuraminidase (NA), inhibit influenza virus replication in MDCK cells, and show potent inhibitory activity against both wild-type and Oseltamivir-resistant influenza strains in vitro[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

(S,R,S)-AHPC-Me-C6-NH2 関連抗体
分子量

571.77

分子式

C30H45N5O4S
CAS 番号
Appearance

Solid

Color

Off-white to light yellow

SMILES

NCCCCCCC(N[C@@H](C(C)(C)C)C(N1[C@@H](C[C@H](C1)O)C(N[C@H](C2=CC=C(C3=C(N=CS3)C)C=C2)C)=O)=O)=O
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
溶剤 & 溶解度
体外: 

DMSO : ≥ 100 mg/mL (174.90 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.7490 mL 8.7448 mL 17.4895 mL
5 mM 0.3498 mL 1.7490 mL 3.4979 mL
10 mM 0.1749 mL 0.8745 mL 1.7490 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始）

C1

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体積 （開始）

V1

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濃度 （終了）

C2

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純度とドキュメンテーション

純度: 99.81%

COA (254 KB) HNMR (390 KB) LCMS (94 KB)

取扱説明書 (2659 KB)
参考文献

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.7490 mL 8.7448 mL 17.4895 mL 43.7239 mL
5 mM 0.3498 mL 1.7490 mL 3.4979 mL 8.7448 mL
10 mM 0.1749 mL 0.8745 mL 1.7490 mL 4.3724 mL
15 mM 0.1166 mL 0.5830 mL 1.1660 mL 2.9149 mL
20 mM 0.0874 mL 0.4372 mL 0.8745 mL 2.1862 mL
25 mM 0.0700 mL 0.3498 mL 0.6996 mL 1.7490 mL
30 mM 0.0583 mL 0.2915 mL 0.5830 mL 1.4575 mL
40 mM 0.0437 mL 0.2186 mL 0.4372 mL 1.0931 mL
50 mM 0.0350 mL 0.1749 mL 0.3498 mL 0.8745 mL
60 mM 0.0291 mL 0.1457 mL 0.2915 mL 0.7287 mL
80 mM 0.0219 mL 0.1093 mL 0.2186 mL 0.5465 mL
100 mM 0.0175 mL 0.0874 mL 0.1749 mL 0.4372 mL
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(S,R,S)-AHPC-Me-C6-NH2 Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量   濃度   体積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(S,R,S)-AHPC-Me-C6-NH22411422-49-4E3 Ligase Ligand-Linker Conjugateswild-type influenza virus strainsinfluenzainfluenza virus neuraminidaseoseltamivir-resistant influenza virus strainsInhibitorinhibitorinhibit

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製品名:
(S,R,S)-AHPC-Me-C6-NH2
製品番号:
HY-139218
数量:
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