2. PROTAC
  3. E3 Ligase Ligand-Linker Conjugates
  4. (S,R,S)-AHPC-phenol-C4-NH2 dihydrochloride

(S,R,S)-AHPC-phenol-C4-NH2 dihydrochloride  (Synonyms: VH032-phenol-C4-NH2 dihydrochloride)

製品番号: HY-136184
COA 取扱説明書 Technical Support

(S,R,S)-AHPC-phenol-C4-NH2 (VH032-phenol-C4-NH2) dihydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and a linker used in PROTAC technology.

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(S,R,S)-AHPC-phenol-C4-NH2 dihydrochloride

(S,R,S)-AHPC-phenol-C4-NH2 dihydrochloride 構造式

CAS 番号 : 2376990-26-8

容量 価格（税別） 在庫状況 数量
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 167 在庫あり
Solution
10 mM * 1 mL in DMSO USD 167 在庫あり
Solid
5 mg $120 在庫あり
10 mg $195 在庫あり
25 mg $390 在庫あり
50 mg $650 在庫あり
100 mg $1040 在庫あり
200 mg   お問い合わせ  
500 mg   お問い合わせ  

* アイテムを追加する前、数量をご選択ください

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(S,R,S)-AHPC-phenol-C4-NH2 dihydrochloride 関連抗体

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E3 Ligase Ligand-Linker Conjugates アイソフォーム固有の製品をすべて表示:

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von Hippel-Lindau (VHL) MDM2 Cereblon cIAP1 Aryl Hydrocarbon Receptor TRIM21

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製品説明

(S,R,S)-AHPC-phenol-C4-NH2 (VH032-phenol-C4-NH2) dihydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and a linker used in PROTAC technology[1].

体外実験

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

(S,R,S)-AHPC-phenol-C4-NH2 dihydrochloride 関連抗体
分子量

632.64

分子式

C28H43Cl2N5O5S
CAS 番号
Appearance

Solid

Color

White to off-white

SMILES

[H]Cl.[H]Cl.CC(N[C@H](C(N1C[C@@H](C[C@H]1C(NCC2=CC=C(C=C2OCCCCN)C3=C(N=CS3)C)=O)O)=O)C(C)(C)C)=O
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
溶剤 & 溶解度
体外: 

DMSO : 100 mg/mL (158.07 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.5807 mL 7.9034 mL 15.8068 mL
5 mM 0.3161 mL 1.5807 mL 3.1614 mL
10 mM 0.1581 mL 0.7903 mL 1.5807 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
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Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始）

C1

×
体積 （開始）

V1

=
濃度 （終了）

C2

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体積 （終了）

V2

In Vivo Dissolution Calculator
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Working solution concentration: mg/mL
純度とドキュメンテーション
参考文献

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.5807 mL 7.9034 mL 15.8068 mL 39.5169 mL
5 mM 0.3161 mL 1.5807 mL 3.1614 mL 7.9034 mL
10 mM 0.1581 mL 0.7903 mL 1.5807 mL 3.9517 mL
15 mM 0.1054 mL 0.5269 mL 1.0538 mL 2.6345 mL
20 mM 0.0790 mL 0.3952 mL 0.7903 mL 1.9758 mL
25 mM 0.0632 mL 0.3161 mL 0.6323 mL 1.5807 mL
30 mM 0.0527 mL 0.2634 mL 0.5269 mL 1.3172 mL
40 mM 0.0395 mL 0.1976 mL 0.3952 mL 0.9879 mL
50 mM 0.0316 mL 0.1581 mL 0.3161 mL 0.7903 mL
60 mM 0.0263 mL 0.1317 mL 0.2634 mL 0.6586 mL
80 mM 0.0198 mL 0.0988 mL 0.1976 mL 0.4940 mL
100 mM 0.0158 mL 0.0790 mL 0.1581 mL 0.3952 mL
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(S,R,S)-AHPC-phenol-C4-NH2 dihydrochloride Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量   濃度   体積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(S,R,S)-AHPC-phenol-C4-NH22376990-26-8VH032-phenol-C4-NH2E3 Ligase Ligand-Linker ConjugatesInhibitorinhibitorinhibit

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製品名:
(S,R,S)-AHPC-phenol-C4-NH2 dihydrochloride
製品番号:
HY-136184
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