(S,R,S)-AHPC-phenol-C4-NH2 dihydrochloride
Based on 1 Customer Validation
(S,R,S)-AHPC-phenol-C4-NH2 (VH032-phenol-C4-NH2) dihydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and a linker used in PROTAC technology.
For research use only. We do not sell to patients.
- CAS No.: 2376990-26-8
- Formula: C28H43Cl2N5O5S
- Molecular Weight:632.64
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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HY-136183
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(S,R,S)-AHPC-PEG3-NH2 hydrochloride -
HY-103604
(S,R,S)-AHPC-PEG4-NH2 hydrochloride -
HY-131387
(S,R,S)-AHPC-Me-CO-CH2-PEG3-NH2 -
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(S,R,S)-AHPC-PEG4-NH2 -
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(S,R,S)-AHPC-Me-C6-NH2 -
HY-136163
(S,R,S)-AHPC-C2-NH2 dihydrochloride -
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(S,R,S)-AHPC-C4-COOH -
HY-129703B
Thalidomide-PEG2-C2-NH2 hydrochloride -
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(S,R,S)-AHPC-C10-NH2 dihydrochloride -
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Thalidomide-4-O-C4-NH2 hydrochloride -
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Thalidomide-4-O-C2-NH2 hydrochloride
All E3 Ligase Ligand-Linker Conjugates Isoforms
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Biological Activity
Description
In Vitro
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2376990-26-8
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Appearance Solid
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Molecular Weight 632.64
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Formula C28H43Cl2N5O5S
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Color White to off-white
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SMILES
[H]Cl.[H]Cl.CC(N[C@H](C(N1C[C@@H](C[C@H]1C(NCC2=CC=C(C=C2OCCCCN)C3=C(N=CS3)C)=O)O)=O)C(C)(C)C)=O
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Synonyms
VH032-phenol-C4-NH2 dihydrochloride
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
In Vitro:
DMSO : 100 mg/mL (158.07 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (278 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
[1]. Scheepstra M, et al. Bivalent Ligands for Protein Degradation in Drug Discovery. Comput Struct Biotechnol J. 2019;17:160-176. Published 2019 Jan 25. [Content Brief]
[2]. [3].Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.5807 mL | 7.9034 mL | 15.8068 mL | 39.5169 mL |
| 5 mM | 0.3161 mL | 1.5807 mL | 3.1614 mL | 7.9034 mL | |
| 10 mM | 0.1581 mL | 0.7903 mL | 1.5807 mL | 3.9517 mL | |
| 15 mM | 0.1054 mL | 0.5269 mL | 1.0538 mL | 2.6345 mL | |
| 20 mM | 0.0790 mL | 0.3952 mL | 0.7903 mL | 1.9758 mL | |
| 25 mM | 0.0632 mL | 0.3161 mL | 0.6323 mL | 1.5807 mL | |
| 30 mM | 0.0527 mL | 0.2634 mL | 0.5269 mL | 1.3172 mL | |
| 40 mM | 0.0395 mL | 0.1976 mL | 0.3952 mL | 0.9879 mL | |
| 50 mM | 0.0316 mL | 0.1581 mL | 0.3161 mL | 0.7903 mL | |
| 60 mM | 0.0263 mL | 0.1317 mL | 0.2634 mL | 0.6586 mL | |
| 80 mM | 0.0198 mL | 0.0988 mL | 0.1976 mL | 0.4940 mL | |
| 100 mM | 0.0158 mL | 0.0790 mL | 0.1581 mL | 0.3952 mL |
(S,R,S)-AHPC-phenol-C4-NH2 dihydrochloride Related Classifications
HY-136184 Related Classifications
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