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Cat. No.: HY-135045

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(S,R,S)-AHPC-C4-COOH

Name: (S,R,S)-AHPC-C4-COOH
Brand: MedChemExpress
SKU: HY-135045
Price: 125.00 USD
Availability: InStock
Rating: 5 (1 reviews)

(Synonyms: VH032-C4-COOH)

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(S,R,S)-AHPC-C4-COOH (VH032-C4-COOH) (linker 45) is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and a linker used for EED-targeted PROTAC.

For research use only. We do not sell to patients.

Purity: 95.92%
CAS No.: 2172819-74-6
Formula: C₂₈H₃₈N₄O₆S
Molecular Weight:558.69

Storage:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month

(S,R,S)-AHPC-C4-COOH Chemical Structure

CAS No.: 2172819-74-6

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
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- In Vitro
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Biological Activity

Description

All E3 Ligase Ligand-Linker Conjugates Isoforms :

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 2172819-74-6
Appearance Solid
Molecular Weight 558.69
Formula C₂₈H₃₈N₄O₆S
Color White to light yellow
SMILES

OC(CCCCC(N[C@@H](C(C)(C)C)C(N1[C@@H](C[C@H](C1)O)C(NCC2=CC=C(C3=C(N=CS3)C)C=C2)=O)=O)=O)=O
Synonyms

VH032-C4-COOH
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (271 KB)
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Liu Jing, et al. Preparation of pyrazolopyridines and related heterocycles as CBP and p300 degradation bivalent compds for treatment of diseases. World Intellectual Property Organization, WO2020173440 A1 2020-09-03

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References

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(S,R,S)-AHPC-C4-COOH

(S,R,S)-AHPC-PEG4-NH2

(S,R,S)-AHPC-PEG2-acid

(S,R,S)-AHPC-(C3-PEG)2-C6-Cl

VH032-C7-COOH

(S,R,S)-AHPC-PEG4-acid

(S,R,S)-AHPC-PEG3-propionic acid

(S,R,S)-AHPC-PEG2-NH2

(S,R,S)-AHPC-PEG1-N3

(S,R,S)-AHPC-PEG3-NH2 hydrochloride

(S,R,S)-AHPC-PEG2-NH2 hydrochloride

(S,R,S)-AHPC monohydrochloride

(S,R,S)-AHPC-phenol-C4-NH2 dihydrochloride

All E3 Ligase Ligand-Linker Conjugates Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

Bioz

(S,R,S)-AHPC-C4-COOH

(S,R,S)-AHPC-PEG4-NH2

(S,R,S)-AHPC-PEG2-acid

(S,R,S)-AHPC-(C3-​PEG)​2-​C6-​Cl

VH032-C7-COOH

(S,R,S)-AHPC-PEG4-acid

(S,R,S)-AHPC-PEG3-propionic acid

(S,R,S)-AHPC-PEG2-NH2

(S,R,S)-AHPC-PEG1-N3

(S,R,S)-AHPC-PEG3-NH2 hydrochloride

(S,R,S)-AHPC-PEG2-NH2 hydrochloride

(S,R,S)-AHPC monohydrochloride

(S,R,S)-AHPC-phenol-C4-NH2 dihydrochloride

All E3 Ligase Ligand-Linker Conjugates Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

(S,R,S)-AHPC-C4-COOH Related Classifications

HY-135045 Related Classifications

Bioz

(S,R,S)-AHPC-(C3-PEG)2-C6-Cl