(S,R,S)-AHPC-PEG4-NH2
Based on 2 publication(s) in Google Scholar
(S,R,S)-AHPC-PEG4-NH2 is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and 4-unit PEG linker used in PROTAC technology.
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- 純度: 95.62%
- CAS 番号: 2010159-57-4
- 分子式: C32H49N5O8S
- 分子量:663.83
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保管条件:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
MedChemExpress（MCE）の使用を引用している文献 (S,R,S)-AHPC-PEG4-NH2
MoreE3 Ligase Ligand-Linker Conjugates アイソフォーム固有の製品をすべて表示
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生物活性
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VHL |
化学情報
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CAS 番号 2010159-57-4
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性状 Solid
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分子量 663.83
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分子式 C32H49N5O8S
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Color White to off-white
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SMILES
O=C(N[C@@H](C(C)(C)C)C(N(C[C@H](O)C1)[C@@H]1C(NCC2=CC=C(C(SC=N3)=C3C)C=C2)=O)=O)COCCOCCOCCOCCN
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別名
VH032-PEG4-NH2; VHL Ligand-Linker Conjugates 4 ; E3 ligase Ligand-Linker Conjugates 7 Free Base
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year
Publications (2)
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Journal Impact Factor
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Most Recent
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ACS Omega
Development of BODIPY FL VH032 as a High-Affinity and Selective von Hippel-Lindau E3 Ligase Fluorescent Probe and Its Application in a Time-Resolved Fluorescence Resonance Energy-Transfer Assay. [Abstract]2020 Dec 29;6(1):680-695. PMID: 33458521 -
Bioconjug Chem
Development of BODIPY FL Thalidomide As a High-Affinity Fluorescent Probe for Cereblon in a Time-Resolved Fluorescence Resonance Energy Transfer Assay. [Abstract]2020 Nov 18;31(11):2564-2575. PMID: 33070611
溶剤 & 溶解度
DMSO : 170 mg/mL (256.09 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (271 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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取扱説明書 (2659 KB)
参考文献
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.5064 mL | 7.5320 mL | 15.0641 mL | 37.6602 mL |
| 5 mM | 0.3013 mL | 1.5064 mL | 3.0128 mL | 7.5320 mL | |
| 10 mM | 0.1506 mL | 0.7532 mL | 1.5064 mL | 3.7660 mL | |
| 15 mM | 0.1004 mL | 0.5021 mL | 1.0043 mL | 2.5107 mL | |
| 20 mM | 0.0753 mL | 0.3766 mL | 0.7532 mL | 1.8830 mL | |
| 25 mM | 0.0603 mL | 0.3013 mL | 0.6026 mL | 1.5064 mL | |
| 30 mM | 0.0502 mL | 0.2511 mL | 0.5021 mL | 1.2553 mL | |
| 40 mM | 0.0377 mL | 0.1883 mL | 0.3766 mL | 0.9415 mL | |
| 50 mM | 0.0301 mL | 0.1506 mL | 0.3013 mL | 0.7532 mL | |
| 60 mM | 0.0251 mL | 0.1255 mL | 0.2511 mL | 0.6277 mL | |
| 80 mM | 0.0188 mL | 0.0942 mL | 0.1883 mL | 0.4708 mL | |
| 100 mM | 0.0151 mL | 0.0753 mL | 0.1506 mL | 0.3766 mL |
(S,R,S)-AHPC-PEG4-NH2 関連分類
HY-103604A 関連分類
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