(S,R,S)-AHPC-C6-NH2
Based on 1 Customer Validation
(S,R,S)-AHPC-C6-NH2 (VH032-C6-NH2) is a synthesized E3 ligase ligand-linker conjugate that incorporates the VH032 based VHL ligand and a linker used in?PROTAC?technology.
For research use only. We do not sell to patients.
- Purity: 98.03%
- CAS No.: 2306389-03-5
- Formula: C29H43N5O4S
- Molecular Weight:557.75
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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HY-103604A
(S,R,S)-AHPC-PEG4-NH2
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HY-103602
(S,R,S)-AHPC-PEG3-NH2 hydrochloride
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HY-103603
(S,R,S)-AHPC-PEG2-NH2 hydrochloride
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HY-103604
(S,R,S)-AHPC-PEG4-NH2 hydrochloride
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HY-136008
(S,R,S)-AHPC-PEG1-NH2
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HY-133487B
(S,R,S)-AHPC-C8-NH2
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HY-103602A
(S,R,S)-AHPC-PEG3-NH2
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HY-103603A
(S,R,S)-AHPC-PEG2-NH2
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HY-141016
(S,R,S)-AHPC-PEG2-acid
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HY-103604AR
(S,R,S)-AHPC-PEG4-NH2 (Standard)
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HY-42424
(S,R,S)-AHPC-Me hydrochloride
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HY-103600
(S,R,S)-AHPC-PEG1-N3
All E3 Ligase Ligand-Linker Conjugates Isoforms
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Biological Activity
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VHL |
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2306389-03-5
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Appearance Solid
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Molecular Weight 557.75
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Formula C29H43N5O4S
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Color Off-white to light yellow
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SMILES
O=C(N(C[C@H](O)C1)[C@@H]1C(NCC2=CC=C(C(SC=N3)=C3C)C=C2)=O)[C@H](C(C)(C)C)NC(CCCCCCN)=O
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Synonyms
VH032-C6-NH2
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year
Solvent & Solubility
DMSO : 100 mg/mL (179.29 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (4.48 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: 2.5 mg/mL (4.48 mM); Suspended solution; Need ultrasonic
This protocol yields a suspended solution of 2.5 mg/mL. Suspended solution can be used for oral and intraperitoneal injection.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
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Data Sheet (271 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
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Handling Instructions (2659 KB)
References
[1]. Scheepstra M, et al. Bivalent Ligands for Protein Degradation in Drug Discovery. Comput Struct Biotechnol J. 2019;17:160-176. Published 2019 Jan 25. [Content Brief]
[2]. Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| DMSO | 1 mM | 1.7929 mL | 8.9646 mL | 17.9292 mL | 44.8229 mL |
| 5 mM | 0.3586 mL | 1.7929 mL | 3.5858 mL | 8.9646 mL | |
| 10 mM | 0.1793 mL | 0.8965 mL | 1.7929 mL | 4.4823 mL | |
| 15 mM | 0.1195 mL | 0.5976 mL | 1.1953 mL | 2.9882 mL | |
| 20 mM | 0.0896 mL | 0.4482 mL | 0.8965 mL | 2.2411 mL | |
| 25 mM | 0.0717 mL | 0.3586 mL | 0.7172 mL | 1.7929 mL | |
| 30 mM | 0.0598 mL | 0.2988 mL | 0.5976 mL | 1.4941 mL | |
| 40 mM | 0.0448 mL | 0.2241 mL | 0.4482 mL | 1.1206 mL | |
| 50 mM | 0.0359 mL | 0.1793 mL | 0.3586 mL | 0.8965 mL | |
| 60 mM | 0.0299 mL | 0.1494 mL | 0.2988 mL | 0.7470 mL | |
| 80 mM | 0.0224 mL | 0.1121 mL | 0.2241 mL | 0.5603 mL | |
| 100 mM | 0.0179 mL | 0.0896 mL | 0.1793 mL | 0.4482 mL |
(S,R,S)-AHPC-C6-NH2 Related Classifications
HY-136006B Related Classifications
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