(S,R,S)-AHPC-C6-NH2 hydrochloride
Based on 1 Customer Validation
(S,R,S)-AHPC-C6-NH2 hydrochloride (VH032-C6-NH2 hydrochloride) is a synthesized E3 ligase ligand-linker conjugate that incorporates the VH032 based VHL ligand and a linker used for AKT PROTAC degrader. (S,R,S)-AHPC-C6-NH2 hydrochloride is XF038-161A, example 6, extracted from patent WO2019173516A1.
For research use only. We do not sell to patients.
- Purity: 99.04%
- CAS No.: 2360522-76-3
- Formula: C29H44ClN5O4S
- Molecular Weight:594.21
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
All E3 Ligase Ligand-Linker Conjugates Isoforms
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Biological Activity
Description
IC50 & Target
[1]|
VHL |
In Vitro
(S,R,S)-AHPC-C6-NH2 hydrochloride (VH032-C5-NH2 hydrochloride) is a synthesized E3 ligase ligand-linker conjugate that incorporates the VH032 based VHL ligand and a linker used for AKT PROTAC degrader, XF038-161A, example 6, extracted from patent WO2019173516A1[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2360522-76-3
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Appearance Solid
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Molecular Weight 594.21
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Formula C29H44ClN5O4S
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Color White to off-white
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SMILES
[H]Cl.O=C(N(C[C@H](O)C1)[C@@H]1C(NCC2=CC=C(C(SC=N3)=C3C)C=C2)=O)[C@H](C(C)(C)C)NC(CCCCCCN)=O
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Synonyms
VH032-C6-NH2 hydrochloride
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
In Vitro:
DMSO : 100 mg/mL (168.29 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (270 KB)
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SDS (254 KB)
- English - EN (254 KB)
- Français - FR (254 KB)
- Deutsch - DE (254 KB)
- Norwegian - NO (254 KB)
- Español - ES (254 KB)
- Swedish - SV (254 KB)
- Italian - IT (254 KB)
- Korean - KR (254 KB)
- Portuguese - PT (254 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.6829 mL | 8.4145 mL | 16.8291 mL | 42.0727 mL |
| 5 mM | 0.3366 mL | 1.6829 mL | 3.3658 mL | 8.4145 mL | |
| 10 mM | 0.1683 mL | 0.8415 mL | 1.6829 mL | 4.2073 mL | |
| 15 mM | 0.1122 mL | 0.5610 mL | 1.1219 mL | 2.8048 mL | |
| 20 mM | 0.0841 mL | 0.4207 mL | 0.8415 mL | 2.1036 mL | |
| 25 mM | 0.0673 mL | 0.3366 mL | 0.6732 mL | 1.6829 mL | |
| 30 mM | 0.0561 mL | 0.2805 mL | 0.5610 mL | 1.4024 mL | |
| 40 mM | 0.0421 mL | 0.2104 mL | 0.4207 mL | 1.0518 mL | |
| 50 mM | 0.0337 mL | 0.1683 mL | 0.3366 mL | 0.8415 mL | |
| 60 mM | 0.0280 mL | 0.1402 mL | 0.2805 mL | 0.7012 mL | |
| 80 mM | 0.0210 mL | 0.1052 mL | 0.2104 mL | 0.5259 mL | |
| 100 mM | 0.0168 mL | 0.0841 mL | 0.1683 mL | 0.4207 mL |
(S,R,S)-AHPC-C6-NH2 hydrochloride Related Classifications
HY-136006A Related Classifications
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