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Cat. No.: HY-143276

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(S,S,R)-AHPC-C6-NH2

(S,S,R)-AHPC-C6-NH2 is the E3 ligase ligand-linker conjugate, which can be utilized for synthesis of PROTAC HL-8 (HY-143275).

For research use only. We do not sell to patients.

CAS No.: 2411422-68-7
Formula: C₂₉H₄₃N₅O₄S
Molecular Weight:557.75

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (270 KB)

(S,S,R)-AHPC-C6-NH2 Chemical Structure

CAS No.: 2411422-68-7

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
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Biological Activity

Description

(S,S,R)-AHPC-C6-NH2 is the E3 ligase ligand-linker conjugate, which can be utilized for synthesis of PROTAC HL-8 (HY-143275)^[1].

All E3 Ligase Ligand-Linker Conjugates Isoforms :

In Vitro

The VHL protein is a substrate recognition subunit of two ubiquitously expressed and biologically important Cullin RING E3 ubiquitin ligase complexes. VHL is one of the most popular E3 ligases being recruited by bifunctional Proteolysis-targeting chimeras (PROTACs) to induce ubiquitination and subsequent proteasomal degradation of a target protein^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 2411422-68-7
Molecular Weight 557.75
Formula C₂₉H₄₃N₅O₄S
SMILES

NCCCCCCC(N[C@@H](C(C)(C)C)C(N1[C@H](C[C@@H](C1)O)C(NCC2=CC=C(C3=C(N=CS3)C)C=C2)=O)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (270 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Wang H, et al. Design, synthesis and activity study of a novel PI3K degradation by hijacking VHL E3 ubiquitin ligase. Bioorg Med Chem. 2022 May 1;61:116707. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
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- In Vitro
Chemical Information
Purity & Documentation
References

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(S,S,R)-AHPC-C6-NH2

All E3 Ligase Ligand-Linker Conjugates Isoforms