(S,R,S)-AHPC-PEG2-NH2
Based on 1 Customer Validation
(S,R,S)-AHPC-PEG2-NH2 (VH032-PEG2-NH2) is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and 2-unit PEG linker used in the synthesis of PROTACs.
For research use only. We do not sell to patients.
- Purity: 98.06%
- CAS No.: 2010159-60-9
- Formula: C28H41N5O6S
- Molecular Weight:575.72
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
All E3 Ligase Ligand-Linker Conjugates Isoforms
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Biological Activity
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VHL |
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2010159-60-9
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Appearance Solid
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Molecular Weight 575.72
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Formula C28H41N5O6S
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Color Off-white to light yellow
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SMILES
O=C([C@H]1N(C([C@@H](NC(COCCOCCN)=O)C(C)(C)C)=O)C[C@H](O)C1)NCC2=CC=C(C3=C(C)N=CS3)C=C2
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Synonyms
VH032-PEG2-NH2 ; VHL Ligand-Linker Conjugates 3 ; E3 ligase Ligand-Linker Conjugates 6 Free Base
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year
Solvent & Solubility
DMSO : 100 mg/mL (173.70 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (274 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| DMSO | 1 mM | 1.7370 mL | 8.6848 mL | 17.3696 mL | 43.4239 mL |
| 5 mM | 0.3474 mL | 1.7370 mL | 3.4739 mL | 8.6848 mL | |
| 10 mM | 0.1737 mL | 0.8685 mL | 1.7370 mL | 4.3424 mL | |
| 15 mM | 0.1158 mL | 0.5790 mL | 1.1580 mL | 2.8949 mL | |
| 20 mM | 0.0868 mL | 0.4342 mL | 0.8685 mL | 2.1712 mL | |
| 25 mM | 0.0695 mL | 0.3474 mL | 0.6948 mL | 1.7370 mL | |
| 30 mM | 0.0579 mL | 0.2895 mL | 0.5790 mL | 1.4475 mL | |
| 40 mM | 0.0434 mL | 0.2171 mL | 0.4342 mL | 1.0856 mL | |
| 50 mM | 0.0347 mL | 0.1737 mL | 0.3474 mL | 0.8685 mL | |
| 60 mM | 0.0289 mL | 0.1447 mL | 0.2895 mL | 0.7237 mL | |
| 80 mM | 0.0217 mL | 0.1086 mL | 0.2171 mL | 0.5428 mL | |
| 100 mM | 0.0174 mL | 0.0868 mL | 0.1737 mL | 0.4342 mL |
(S,R,S)-AHPC-PEG2-NH2 Related Classifications
HY-103603A Related Classifications
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