2. PROTAC
  3. E3 Ligase Ligand-Linker Conjugates
  4. (S,R,S)-AHPC-PEG2-NH2

(S,R,S)-AHPC-PEG2-NH2  (Synonyms: VH032-PEG2-NH2 ; VHL Ligand-Linker Conjugates 3 ; E3 ligase Ligand-Linker Conjugates 6 Free Base)

Cat. No.: HY-103603A Purity: 98.06%
COA
SDS
Handling Instructions Technical Support

(S,R,S)-AHPC-PEG2-NH2 (VH032-PEG2-NH2) is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and 2-unit PEG linker used in the synthesis of PROTACs.

For research use only. We do not sell to patients.

(S,R,S)-AHPC-PEG2-NH2

(S,R,S)-AHPC-PEG2-NH2 Chemical Structure

CAS No. : 2010159-60-9

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Other Forms of (S,R,S)-AHPC-PEG2-NH2:

(S,R,S)-AHPC-PEG2-NH2 Related Antibodies

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von Hippel-Lindau (VHL) MDM2 Cereblon cIAP1 Aryl Hydrocarbon Receptor TRIM21

  • Biological Activity

  • Purity & Documentation

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Description

(S,R,S)-AHPC-PEG2-NH2 (VH032-PEG2-NH2) is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and 2-unit PEG linker used in the synthesis of PROTACs[1].

IC50 & Target[1]

VHL

 

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

(S,R,S)-AHPC-PEG2-NH2 Related Antibodies
Molecular Weight

575.72

Formula

C28H41N5O6S
CAS No.
Appearance

Solid

Color

Off-white to light yellow

SMILES

O=C([C@H]1N(C([C@@H](NC(COCCOCCN)=O)C(C)(C)C)=O)C[C@H](O)C1)NCC2=CC=C(C3=C(C)N=CS3)C=C2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (173.70 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.7370 mL 8.6848 mL 17.3696 mL
5 mM 0.3474 mL 1.7370 mL 3.4739 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 98.06%

SDS (393 KB)

COA (253 KB) HNMR (146 KB) RP-HPLC (131 KB) NP-HPLC (166 KB) LCMS (387 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.7370 mL 8.6848 mL 17.3696 mL 43.4239 mL
5 mM 0.3474 mL 1.7370 mL 3.4739 mL 8.6848 mL
10 mM 0.1737 mL 0.8685 mL 1.7370 mL 4.3424 mL
15 mM 0.1158 mL 0.5790 mL 1.1580 mL 2.8949 mL
20 mM 0.0868 mL 0.4342 mL 0.8685 mL 2.1712 mL
25 mM 0.0695 mL 0.3474 mL 0.6948 mL 1.7370 mL
30 mM 0.0579 mL 0.2895 mL 0.5790 mL 1.4475 mL
40 mM 0.0434 mL 0.2171 mL 0.4342 mL 1.0856 mL
50 mM 0.0347 mL 0.1737 mL 0.3474 mL 0.8685 mL
60 mM 0.0289 mL 0.1447 mL 0.2895 mL 0.7237 mL
80 mM 0.0217 mL 0.1086 mL 0.2171 mL 0.5428 mL
100 mM 0.0174 mL 0.0868 mL 0.1737 mL 0.4342 mL
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(S,R,S)-AHPC-PEG2-NH2 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(S,R,S)-AHPC-PEG2-NH22010159-60-9VH032-PEG2-NH2 VHL Ligand-Linker Conjugates 3 E3 ligase Ligand-Linker Conjugates 6E3 Ligase Ligand-Linker ConjugatesInhibitorinhibitorinhibit

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