(S,R,S)-AHPC-C2-NH2 dihydrochloride
Based on 1 Customer Validation
(S,R,S)-AHPC-C2-NH2 dihydrochloride incorporates a VHL ligand for the E3 ubiquitin ligase, and a PROTAC linker. (S,R,S)-AHPC-OH can be used in the synthesis of a series of PROTACs.
For research use only. We do not sell to patients.
- Purity : 98.63%
- CAS No.: 2341796-73-2
- Formula: C25H37Cl2N5O4S
- Molecular Weight:574.56
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Storage:
4°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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HY-103602
(S,R,S)-AHPC-PEG3-NH2 hydrochloride -
HY-114176
(S,R,S)-AHPC-C4-NH2 hydrochloride -
HY-101763A
(S,R,S)-AHPC monohydrochloride -
HY-136237
Thalidomide-NH-C5-NH2 hydrochloride -
HY-103603A
(S,R,S)-AHPC-PEG2-NH2 -
HY-136008
(S,R,S)-AHPC-PEG1-NH2 -
HY-130711C
(S,R,S)-AHPC-C3-NH2 dihydrochloride -
HY-103600
(S,R,S)-AHPC-PEG1-N3 -
HY-103603
(S,R,S)-AHPC-PEG2-NH2 hydrochloride -
HY-103604
(S,R,S)-AHPC-PEG4-NH2 hydrochloride -
HY-129941A
(S,R,S)-AHPC-C10-NH2 dihydrochloride -
HY-103606
(S,R,S)-AHPC-PEG6-C4-Cl
All E3 Ligase Ligand-Linker Conjugates Isoforms
More
Biological Activity
Description
IC50 & Target
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VHL |
In Vitro
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2341796-73-2
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Appearance Solid
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Molecular Weight 574.56
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Formula C25H37Cl2N5O4S
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Color White to yellow
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SMILES
O=C(N(C[C@@H]1O)[C@@H](C1)C(NCC2=CC=C(C(SC=N3)=C3C)C=C2)=O)[C@H](C(C)(C)C)NC(CCN)=O.Cl.Cl
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
Solvent & Solubility
In Vitro:
DMSO : 250 mg/mL (435.12 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
In Vivo:
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.08 mg/mL (3.62 mM); Clear solution
This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.08 mg/mL (3.62 mM); Clear solution
This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL. * In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
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Data Sheet (279 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.7405 mL | 8.7023 mL | 17.4046 mL | 43.5116 mL |
| 5 mM | 0.3481 mL | 1.7405 mL | 3.4809 mL | 8.7023 mL | |
| 10 mM | 0.1740 mL | 0.8702 mL | 1.7405 mL | 4.3512 mL | |
| 15 mM | 0.1160 mL | 0.5802 mL | 1.1603 mL | 2.9008 mL | |
| 20 mM | 0.0870 mL | 0.4351 mL | 0.8702 mL | 2.1756 mL | |
| 25 mM | 0.0696 mL | 0.3481 mL | 0.6962 mL | 1.7405 mL | |
| 30 mM | 0.0580 mL | 0.2901 mL | 0.5802 mL | 1.4504 mL | |
| 40 mM | 0.0435 mL | 0.2176 mL | 0.4351 mL | 1.0878 mL | |
| 50 mM | 0.0348 mL | 0.1740 mL | 0.3481 mL | 0.8702 mL | |
| 60 mM | 0.0290 mL | 0.1450 mL | 0.2901 mL | 0.7252 mL | |
| 80 mM | 0.0218 mL | 0.1088 mL | 0.2176 mL | 0.5439 mL | |
| 100 mM | 0.0174 mL | 0.0870 mL | 0.1740 mL | 0.4351 mL |
(S,R,S)-AHPC-C2-NH2 dihydrochloride Related Classifications
HY-136163 Related Classifications
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