1. PROTAC
  2. E3 Ligase Ligand-Linker Conjugate
  3. (S,R,S)-AHPC-C10-NH2 dihydrochloride

(S,R,S)-AHPC-C10-NH2 dihydrochloride (Synonyms: VH032-C10-NH2 dihydrochloride)

Cat. No.: HY-129941A
Handling Instructions

(S,R,S)-AHPC-C10-NH2 dihydrochloride (VH032-C10-NH2 dihydrochloride) is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and a linker used for BET-Targeted PROTAC.

For research use only. We do not sell to patients.

(S,R,S)-AHPC-C10-NH2 dihydrochloride Chemical Structure

(S,R,S)-AHPC-C10-NH2 dihydrochloride Chemical Structure

CAS No. : 2341796-75-4

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Other Forms of (S,R,S)-AHPC-C10-NH2 dihydrochloride:

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Description

(S,R,S)-AHPC-C10-NH2 dihydrochloride (VH032-C10-NH2 dihydrochloride) is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and a linker used for BET-Targeted PROTAC[1].

IC50 & Target[1]

VHL

 

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

686.78

Formula

C₃₃H₅₃Cl₂N₅O₄S

CAS No.
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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent & Solubility
In Vitro: 

H2O : 250 mg/mL (364.02 mM; Need ultrasonic)

DMSO : 250 mg/mL (364.02 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.4561 mL 7.2804 mL 14.5607 mL
5 mM 0.2912 mL 1.4561 mL 2.9121 mL
10 mM 0.1456 mL 0.7280 mL 1.4561 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (3.03 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (3.03 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (3.03 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Product Name:
(S,R,S)-AHPC-C10-NH2 dihydrochloride
Cat. No.:
HY-129941A
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