(S,R,S)-AHPC-C10-NH2 dihydrochloride
Based on 1 Customer Validation
(S,R,S)-AHPC-C10-NH2 dihydrochloride (VH032-C10-NH2 dihydrochloride) is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and a linker used for BET-Targeted PROTAC.
For research use only. We do not sell to patients.
- Purity : 96.74%
- CAS No.: 2341796-75-4
- Formula: C33H53Cl2N5O4S
- Molecular Weight:686.78
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Storage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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HY-103602
(S,R,S)-AHPC-PEG3-NH2 hydrochloride -
HY-129703B
Thalidomide-PEG2-C2-NH2 hydrochloride -
HY-131888
Pomalidomide-C3-NH2 hydrochloride -
HY-136237
Thalidomide-NH-C5-NH2 hydrochloride -
HY-136008
(S,R,S)-AHPC-PEG1-NH2 -
HY-122694A
Thalidomide-O-amido-PEG-C2-NH2 hydrochloride -
HY-131867
Thalidomide-NH-PEG1-NH2 hydrochloride -
HY-103600
(S,R,S)-AHPC-PEG1-N3 -
HY-103604
(S,R,S)-AHPC-PEG4-NH2 hydrochloride -
HY-103598
(S,R,S)-AHPC-PEG3-N3 -
HY-103603
(S,R,S)-AHPC-PEG2-NH2 hydrochloride -
HY-136163
(S,R,S)-AHPC-C2-NH2 dihydrochloride
All E3 Ligase Ligand-Linker Conjugates Isoforms
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Biological Activity
Description
IC50 & Target
[1]|
VHL |
In Vitro
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2341796-75-4
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Appearance Solid
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Molecular Weight 686.78
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Formula C33H53Cl2N5O4S
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Color Light yellow to yellow
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SMILES
NCCCCCCCCCCC(N[C@@H](C(C)(C)C)C(N1[C@H](C(NCC2=CC=C(C3=C(C)N=CS3)C=C2)=O)C[C@@H](O)C1)=O)=O.Cl.Cl
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Synonyms
VH032-C10-NH2 dihydrochloride
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
In Vitro:
H2O : 250 mg/mL (364.02 mM; Need ultrasonic)
DMSO : 250 mg/mL (364.02 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
In Vivo:
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.08 mg/mL (3.03 mM); Clear solution
This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.08 mg/mL (3.03 mM); Clear solution
This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Working solution concentration: 0.22 mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
Purity & Documentation
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Data Sheet (272 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O / DMSO | 1 mM | 1.4561 mL | 7.2804 mL | 14.5607 mL | 36.4018 mL |
| 5 mM | 0.2912 mL | 1.4561 mL | 2.9121 mL | 7.2804 mL | |
| 10 mM | 0.1456 mL | 0.7280 mL | 1.4561 mL | 3.6402 mL | |
| 15 mM | 0.0971 mL | 0.4854 mL | 0.9707 mL | 2.4268 mL | |
| 20 mM | 0.0728 mL | 0.3640 mL | 0.7280 mL | 1.8201 mL | |
| 25 mM | 0.0582 mL | 0.2912 mL | 0.5824 mL | 1.4561 mL | |
| 30 mM | 0.0485 mL | 0.2427 mL | 0.4854 mL | 1.2134 mL | |
| 40 mM | 0.0364 mL | 0.1820 mL | 0.3640 mL | 0.9100 mL | |
| 50 mM | 0.0291 mL | 0.1456 mL | 0.2912 mL | 0.7280 mL | |
| 60 mM | 0.0243 mL | 0.1213 mL | 0.2427 mL | 0.6067 mL | |
| 80 mM | 0.0182 mL | 0.0910 mL | 0.1820 mL | 0.4550 mL | |
| 100 mM | 0.0146 mL | 0.0728 mL | 0.1456 mL | 0.3640 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
(S,R,S)-AHPC-C10-NH2 dihydrochloride Related Classifications
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