1. PROTAC
  2. E3 Ligase Ligand-Linker Conjugate
  3. Thalidomide-O-amido-PEG-C2-NH2 hydrochloride

Thalidomide-O-amido-PEG-C2-NH2 hydrochloride 

Cat. No.: HY-122694A
Handling Instructions

Thalidomide-O-amido-PEG-C2-NH2 hydrochloride, a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker, can be used in the synthesis of PROTACs.

For research use only. We do not sell to patients.

Thalidomide-O-amido-PEG-C2-NH2 hydrochloride Chemical Structure

Thalidomide-O-amido-PEG-C2-NH2 hydrochloride Chemical Structure

CAS No. : 2204226-02-6

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Description

Thalidomide-O-amido-PEG-C2-NH2 hydrochloride, a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker, can be used in the synthesis of PROTACs[1].

IC50 & Target

Cereblon

 

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

Molecular Weight

454.86

Formula

C₁₉H₂₃ClN₄O₇

CAS No.

2204226-02-6

SMILES

O=C(NCCOCCN)COC1=CC=CC(C(N2C(CC3)C(NC3=O)=O)=O)=C1C2=O.Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

Thalidomide-O-amido-PEG-C2-NH2E3 Ligase Ligand-Linker ConjugateInhibitorinhibitorinhibit

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Product name:
Thalidomide-O-amido-PEG-C2-NH2 hydrochloride
Cat. No.:
HY-122694A
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