2. PROTAC
  3. E3 Ligase Ligand-Linker Conjugates
  4. Thalidomide-NH-PEG3-propionic acid

Thalidomide-NH-PEG3-propionic acid 

Cat. No.: HY-136166 Purity: 99.72%
COA Handling Instructions

Thalidomide-NH-PEG3-propionic acid is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and 3-unit PEG linker used in PROTAC technology.

For research use only. We do not sell to patients.

Thalidomide-NH-PEG3-propionic acid Chemical Structure

Thalidomide-NH-PEG3-propionic acid Chemical Structure

CAS No. : 2138440-82-9

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25 mg USD 180 In-stock
100 mg USD 650 In-stock
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Based on 1 publication(s) in Google Scholar

Top Publications Citing Use of Products

View All E3 Ligase Ligand-Linker Conjugates Isoform Specific Products:

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von Hippel-Lindau (VHL) MDM2 Cereblon cIAP1

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Description

Thalidomide-NH-PEG3-propionic acid is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and 3-unit PEG linker used in PROTAC technology[1].

IC50 & Target[1]

Cereblon

 

Molecular Weight

477.46

Appearance

Solid

Formula

C22H27N3O9
CAS No.
SMILES

O=C(O)CCOCCOCCOCCNC1=CC=CC(C(N2C(CC3)C(NC3=O)=O)=O)=C1C2=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (261.80 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.0944 mL 10.4721 mL 20.9442 mL
5 mM 0.4189 mL 2.0944 mL 4.1888 mL
10 mM 0.2094 mL 1.0472 mL 2.0944 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (4.36 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (4.36 mM); Clear solution

*All of the co-solvents are available by MCE.
Purity & Documentation

Purity: 99.72%

COA (245 KB) HNMR (282 KB) LCMS (98 KB)

Handling Instructions (2659 KB)
References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

Thalidomide-NH-PEG3-propionic acid2138440-82-9E3 Ligase Ligand-Linker ConjugatesE3-ligasesynthesizedThalidomidePROTACInhibitorinhibitorinhibit

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