Pomalidomide-PEG6-NH2 hydrochloride
Pomalidomide-PEG6-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and 6-unit PEG linker used in PROTAC technology.
For research use only. We do not sell to patients.
- Purity: 98.01%
- CAS No.: 2341841-01-6
- Formula: C25H36ClN3O10
- Molecular Weight:574.02
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Storage:
-20°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
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Help & FAQs
All E3 Ligase Ligand-Linker Conjugates Isoforms
More
Biological Activity
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Cereblon |
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2341841-01-6
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Appearance Oil
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Molecular Weight 574.02
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Formula C25H36ClN3O10
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Color Light yellow to brown
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SMILES
O=C1N(C(CC2)C(NC2=O)=O)C(C3=C1C=CC=C3OCCOCCOCCOCCOCCOCCN)=O.[H]Cl
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Solvent & Solubility
DMSO : 125 mg/mL (217.76 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (240 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.7421 mL | 8.7105 mL | 17.4210 mL | 43.5525 mL |
| 5 mM | 0.3484 mL | 1.7421 mL | 3.4842 mL | 8.7105 mL | |
| 10 mM | 0.1742 mL | 0.8710 mL | 1.7421 mL | 4.3552 mL | |
| 15 mM | 0.1161 mL | 0.5807 mL | 1.1614 mL | 2.9035 mL | |
| 20 mM | 0.0871 mL | 0.4355 mL | 0.8710 mL | 2.1776 mL | |
| 25 mM | 0.0697 mL | 0.3484 mL | 0.6968 mL | 1.7421 mL | |
| 30 mM | 0.0581 mL | 0.2903 mL | 0.5807 mL | 1.4517 mL | |
| 40 mM | 0.0436 mL | 0.2178 mL | 0.4355 mL | 1.0888 mL | |
| 50 mM | 0.0348 mL | 0.1742 mL | 0.3484 mL | 0.8710 mL | |
| 60 mM | 0.0290 mL | 0.1452 mL | 0.2903 mL | 0.7259 mL | |
| 80 mM | 0.0218 mL | 0.1089 mL | 0.2178 mL | 0.5444 mL | |
| 100 mM | 0.0174 mL | 0.0871 mL | 0.1742 mL | 0.4355 mL |
Pomalidomide-PEG6-NH2 hydrochloride Related Classifications
HY-136161 Related Classifications
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