2. PROTAC
  3. E3 Ligase Ligand-Linker Conjugates
  4. Pomalidomide-PEG6-NH2 hydrochloride

Pomalidomide-PEG6-NH2 hydrochloride 

Cat. No.: HY-136161 Purity: 98.01%
COA Handling Instructions

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Pomalidomide-PEG6-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and 6-unit PEG linker used in PROTAC technology.

For research use only. We do not sell to patients.

Pomalidomide-PEG6-NH2 hydrochloride Chemical Structure

Pomalidomide-PEG6-NH2 hydrochloride Chemical Structure

CAS No. : 2341841-01-6

Size Price Stock Quantity
5 mg USD 204 In-stock
10 mg USD 326 In-stock
25 mg USD 586 Get quote 2 weeks 1 week
50 mg   Get quote  
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Based on 1 publication(s) in Google Scholar

Pomalidomide-PEG6-NH2 hydrochloride Related Antibodies

Top Publications Citing Use of Products

View All E3 Ligase Ligand-Linker Conjugates Isoform Specific Products:

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von Hippel-Lindau (VHL) MDM2 Cereblon cIAP1 Aryl Hydrocarbon Receptor

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Description

Pomalidomide-PEG6-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and 6-unit PEG linker used in PROTAC technology.

IC50 & Target[1]

Cereblon

 

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Pomalidomide-PEG6-NH2 hydrochloride Related Antibodies
Molecular Weight

574.02

Formula

C25H36ClN3O10
CAS No.
Appearance

Oil

Color

Light yellow to brown

SMILES

O=C1N(C(CC2)C(NC2=O)=O)C(C3=C1C=CC=C3OCCOCCOCCOCCOCCOCCN)=O.[H]Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (217.76 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.7421 mL 8.7105 mL 17.4210 mL
5 mM 0.3484 mL 1.7421 mL 3.4842 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 98.01%

COA (244 KB) HNMR (298 KB) LCMS (88 KB)

Handling Instructions (2659 KB)

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.7421 mL 8.7105 mL 17.4210 mL 43.5525 mL
5 mM 0.3484 mL 1.7421 mL 3.4842 mL 8.7105 mL
10 mM 0.1742 mL 0.8710 mL 1.7421 mL 4.3552 mL
15 mM 0.1161 mL 0.5807 mL 1.1614 mL 2.9035 mL
20 mM 0.0871 mL 0.4355 mL 0.8710 mL 2.1776 mL
25 mM 0.0697 mL 0.3484 mL 0.6968 mL 1.7421 mL
30 mM 0.0581 mL 0.2903 mL 0.5807 mL 1.4517 mL
40 mM 0.0436 mL 0.2178 mL 0.4355 mL 1.0888 mL
50 mM 0.0348 mL 0.1742 mL 0.3484 mL 0.8710 mL
60 mM 0.0290 mL 0.1452 mL 0.2903 mL 0.7259 mL
80 mM 0.0218 mL 0.1089 mL 0.2178 mL 0.5444 mL
100 mM 0.0174 mL 0.0871 mL 0.1742 mL 0.4355 mL
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Pomalidomide-PEG6-NH2 hydrochloride Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Pomalidomide-PEG6-NH22341841-01-6E3 Ligase Ligand-Linker ConjugatesInhibitorinhibitorinhibit

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