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Cat. No.: HY-112618B

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Thalidomide-O-amido-C6-NH2 hydrochloride

Name: Thalidomide-O-amido-C6-NH2 hydrochloride
Brand: MedChemExpress
SKU: HY-112618B
Price: 160.00 USD
Availability: InStock
Rating: 5 (1 reviews)

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Thalidomide-O-amido-C6-NH2 hydrochloride, a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker, can be used in the synthesis of PROTACs.

For research use only. We do not sell to patients.

Purity: 99.32%
CAS No.: 2376990-31-5
Formula: C₂₁H₂₇ClN₄O₆
Molecular Weight:466.92

Storage:

4°C, sealed storage, away from moisture and light

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Thalidomide-O-amido-C6-NH2 hydrochloride Chemical Structure

CAS No.: 2376990-31-5

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
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Classifications
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Biological Activity

Description

IC₅₀ & Target

Cereblon

All E3 Ligase Ligand-Linker Conjugates Isoforms :

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 2376990-31-5
Appearance Solid
Molecular Weight 466.92
Formula C₂₁H₂₇ClN₄O₆
Color White to off-white
SMILES

O=C(COC1=CC=CC(C(N2C(C(N3)=O)CCC3=O)=O)=C1C2=O)NCCCCCCN.Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture and light

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (266 KB)
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Bradner J, et al. Targeted protein degradation to attenuate adoptive t-cell therapy associated adverse inflammatory responses. WO 2017024318 A1

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Keywords

Thalidomide-O-amido-C6-NH2 hydrochloride

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References

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(S,R,S)-AHPC-phenol-C4-NH2 dihydrochloride

(S,R,S)-AHPC-phenol-alkylC6-amine dihydrochloride

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All E3 Ligase Ligand-Linker Conjugates Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

Thalidomide-O-amido-C6-NH2 hydrochloride Related Classifications

HY-112618B Related Classifications

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