Thalidomide-4-O-C6-NH2 hydrochloride
Based on 1 Customer Validation
Thalidomide-4-O-C6-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate used in the PROTAC dTAG-13, a degrader of FKBP12F36V and BET.
For research use only. We do not sell to patients.
- Purity: 99.11%
- CAS No.: 2245697-88-3
- Formula: C19H24ClN3O5
- Molecular Weight:409.86
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Storage:
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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HY-136162
Thalidomide-4-O-C2-NH2 hydrochloride
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Pomalidomide-PEG3-C2-NH2 hydrochloride
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HY-129703B
Thalidomide-PEG2-C2-NH2 hydrochloride
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HY-131867
Thalidomide-NH-PEG1-NH2 hydrochloride
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HY-130948B
Thalidomide-4-O-C4-NH2 hydrochloride
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HY-112618B
Thalidomide-O-amido-C6-NH2 hydrochloride
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HY-133699
Pomalidomide-PEG4-COOH
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HY-107438A
Thalidomide-O-amido-C4-NH2 hydrochloride
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HY-130737
Pomalidomide 4'-alkylC5-acid
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HY-103597
Thalidomide-O-COOH
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HY-122694A
Thalidomide-O-amido-PEG-C2-NH2 hydrochloride
All E3 Ligase Ligand-Linker Conjugates Isoforms
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Biological Activity
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Cereblon |
Chemical Information
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CAS No. 2245697-88-3
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Appearance Solid
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Molecular Weight 409.86
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Formula C19H24ClN3O5
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Color Light yellow to yellow
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SMILES
O=C1N(C(CC2)C(NC2=O)=O)C(C3=C1C=CC=C3OCCCCCCN)=O.[H]Cl
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Solvent & Solubility
DMSO : 83.33 mg/mL (203.31 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
H2O : 25 mg/mL (61.00 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.08 mg/mL (5.07 mM); Clear solution
This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.08 mg/mL (5.07 mM); Clear solution
This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
For the following dissolution methods, please prepare the working solution directly:
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: PBS
Solubility: 8.33 mg/mL (20.32 mM); Clear solution; Need ultrasonic
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Working solution concentration: 0.22 mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
Purity & Documentation
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Data Sheet (271 KB)
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SDS (644 KB)
- English - EN (644 KB)
- Français - FR (644 KB)
- Deutsch - DE (644 KB)
- Norwegian - NO (644 KB)
- Español - ES (644 KB)
- Swedish - SV (644 KB)
- Italian - IT (644 KB)
- Korean - KR (644 KB)
- Portuguese - PT (644 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O / DMSO | 1 mM | 2.4399 mL | 12.1993 mL | 24.3986 mL | 60.9964 mL |
| 5 mM | 0.4880 mL | 2.4399 mL | 4.8797 mL | 12.1993 mL | |
| 10 mM | 0.2440 mL | 1.2199 mL | 2.4399 mL | 6.0996 mL | |
| 15 mM | 0.1627 mL | 0.8133 mL | 1.6266 mL | 4.0664 mL | |
| 20 mM | 0.1220 mL | 0.6100 mL | 1.2199 mL | 3.0498 mL | |
| 25 mM | 0.0976 mL | 0.4880 mL | 0.9759 mL | 2.4399 mL | |
| 30 mM | 0.0813 mL | 0.4066 mL | 0.8133 mL | 2.0332 mL | |
| 40 mM | 0.0610 mL | 0.3050 mL | 0.6100 mL | 1.5249 mL | |
| 50 mM | 0.0488 mL | 0.2440 mL | 0.4880 mL | 1.2199 mL | |
| 60 mM | 0.0407 mL | 0.2033 mL | 0.4066 mL | 1.0166 mL | |
| DMSO | 80 mM | 0.0305 mL | 0.1525 mL | 0.3050 mL | 0.7625 mL |
| 100 mM | 0.0244 mL | 0.1220 mL | 0.2440 mL | 0.6100 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Thalidomide-4-O-C6-NH2 hydrochloride Related Classifications
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